Iron
→Inflammation

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5

1

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↓5

—1

Evidence suggests Iron mayincreaseInflammation.

16 studies (17 claims)

Moderate consensus

Typical effective dose 25005 (12507.5–37502.5) mgacross 2 dosed studies

Study Claims

18 of 20

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
oral ferrous iron	Increases - is known to induce inflammation	inflammation	Human	—	Not provided in the abstract.	Acute Administration of Bioavailable Curcumin Alongside Ferrous Sulphate Supplements Does Not Impair Iron Absorption in Healthy Adults in a Randomised Trial.cited 5×
provision of a prebiotic together with iron	Decreases - may alleviate the adverse effects of iron on the gut microbiome and gut inflammation	adverse effects of iron on the gut microbiome and gut inflammation	Human	infants	Not specified	Interventions to prevent iron deficiency during the first 1000 days in low-income and middle-income countries: recent advances and challenges.cited 4×
iron supplementation therapy	No effect - may be considered	anemia of inflammation	Human	patients where underlying disease and/or anemia are not resolved	Not specified	Physiology and Inflammation Driven Pathophysiology of Iron Homeostasis-Mechanistic Insights into Anemia of Inflammation and Its Treatment.cited 66×
iron intervention	Increases - causes unfavourable shifts in the gut microbial composition along with increases in	intestinal inflammation	Human	children with a high infectious disease burden	Not specified	Iron interventions in children from low-income and middle-income populations: benefits and risks.cited 7×
oral iron supplementation	Increases - can be burdened with	local-intestinal inflammation	Human	—	Not specified	The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia-A Narrative Review.cited 45×
oral iron supplementation	Increases - can be burdened with	systemic inflammation	Human	—	Not specified	The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia-A Narrative Review.cited 45×
parenteral iron supplementation	Increases - can be burdened with	local-intestinal inflammation	Human	—	Not specified	The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia-A Narrative Review.cited 45×
parenteral iron supplementation	Increases - can be burdened with	systemic inflammation	Human	—	Not specified	The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia-A Narrative Review.cited 45×
Hepcidin upregulation by oral iron supplementation	Decreases - limits the absorption efficiency	absorption efficiency of oral iron during inflammation	Human	—	Not specified	Iron deficiency.cited 520×
haem iron	No effect - absorption may not be decreased by	inflammation	Human	—	10.0 mg of elemental iron daily, either as haem or ferrous sulphate.	Haem iron versus ferrous iron salts to treat iron deficiency anaemia in Gambian children: protocol for randomised controlled trial {1}.cited 2×
Iron	Increases - only had minor effects	inflammation	Human	patients undergoing haemodialysis	Not specified (infused before iron sucrose at 50 or 100 mg).	Randomized clinical trial on acute effects of i.v. iron sucrose during haemodialysis.cited 29×
iron therapy	Increases - induces	inflammation	Human	—	6 mg/kg/day of iron with or without 18 mg/day of vitamin E.	Effect of Vitamin E With Therapeutic Iron Supplementation on Iron Repletion and Gut Microbiome in US Iron Deficient Infants and Toddlers.cited 49×
failure to resolve the functional iron deficiency following cell exposure to particles	Increases - results in	release of inflammatory mediators and inflammation	Molecular	cells	Not specified	Air pollution particles and iron homeostasis.cited 19×
new oral iron therapy products	No effect - effective in treating	anemia of inflammation	Human	—	Not specified	Update on iron supplementation in patients with cancer-related anemia.
intravenous iron preparations	Increases - can cause	inflammation	Human	—	Not specified	Iron overdose: a contributor to adverse outcomes in randomized trials of anemia correction in CKD.cited 30×
prebiotics added to iron-fortified infant cereal	Decreases - reduces	adverse effects of iron on inflammation	Human	Kenyan infants	—	Prebiotics increase iron absorption and reduce the adverse effects of iron on the gut microbiome and inflammation: a randomized controlled trial using iron stable isotopes in Kenyan infants.cited 8×
Selenium, calcium, magnesium, zinc, and iron	Decreases - hold the promise of reducing	inflammation	Human	patients with IBD	Not specified	Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease.cited 4×
Selenium, calcium, magnesium, zinc, and iron	Decreases - could play a crucial role in mitigating	inflammation	Human	patients with IBD	Not specified	Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease.cited 4×