40
5
↑0
↓40
—5
Evidence suggests Calcium maydecreaseBone loss.
29 studies (45 claims)
Strong consensus
Typical effective dose 500 (500–500) mgacross 5 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| 2 doses of zoledronic acid (ZA) and supplementation with calcium and vitamin D | Decreases - effectively prevent further bone loss | bone loss | Human | patients with newly diagnosed lymphoma | Oral calcium and vitamin D daily (specific dosage not mentioned); ZA administered at enrollment and 6 months later. | Zoledronic acid for prevention of bone loss in patients receiving primary therapy for lymphomas: a prospective, randomized controlled phase III trial.cited 26× |
| Vitamin D and calcium supplements | Decreases - can reduce | bone loss | Human | young DTC patients with vitamin D malnutrition after thyroidectomy | 1000-2000 IU vitamin D3 and 600 mg elemental calcium daily. | Effects of vitamin D3 and calcium supplementation on bone of young adults after thyroidectomy of differentiated thyroid carcinoma. |
| oral supplementation with antioxidant agents containing alpha lipoic acid (ALA) plus calcium and vitamin D3 | Decreases - may mitigate bone loss | bone loss | Human | osteopenic postmenopausal women | Not specified (only mentions "calcium and vitamin D3" without dosage details). | Oral supplementation with antioxidant agents containing alpha lipoic acid: effects on postmenopausal bone mass.cited 18× |
| elemental calcium 500 mg/day | Decreases - slowing bone loss | bone loss at femoral neck | Human | elderly Thai women who had low dietary calcium intake | 500 mg elemental calcium per day | The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.cited 14× |
| elemental calcium 500 mg/day | Decreases - is effective in retarding bone loss | bone loss at lumbar spine | Human | elderly Thai women who had low dietary calcium intake | 500 mg elemental calcium per day | The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.cited 14× |
| Calcium supplementation | Decreases - necessary for the prevention | bone loss | Human | Thai elderly women | 500 mg elemental calcium per day | The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.cited 14× |
| calcium supplements of 250 mg/d | Decreases - effectively prevent bone loss | bone loss | Human | perimenopausal and postmenopausal Japanese women | 500 mg/d or 250 mg/d (as calcium carbonate). | Effect of low-dose calcium supplements on bone loss in perimenopausal and postmenopausal Asian women: a randomized controlled trial.cited 22× |
| calcium supplements of 500 mg/d | Decreases - effectively prevent bone loss | bone loss | Human | perimenopausal and postmenopausal Japanese women | 500 mg/d or 250 mg/d (as calcium carbonate). | Effect of low-dose calcium supplements on bone loss in perimenopausal and postmenopausal Asian women: a randomized controlled trial.cited 22× |
| low-dose calcium supplement of 500 mg/d | Decreases - can effectively slow | lumbar spine bone loss | Human | perimenopausal and postmenopausal women with habitually low calcium intake | 500 mg/d or 250 mg/d (as calcium carbonate). | Effect of low-dose calcium supplements on bone loss in perimenopausal and postmenopausal Asian women: a randomized controlled trial.cited 22× |
| appropriate calcium and vitamin D supplementation | Decreases - prevention | cancer therapy-induced bone loss | Human | — | Not specified | Bone homeostasis and breast cancer: implications for complex therapy and the maintenance of bone integrity.cited 3× |
| Oral administration of bovine collagen peptide (CP) combined with calcium citrate (CC) | Decreases - has been found to inhibit | bone loss | Animal | ovariectomized rats | — | Effect of Collagen Peptide, Alone and in Combination with Calcium Citrate, on Bone Loss in Tail-Suspended Rats. |
| Oral administration of bovine collagen peptide (CP) combined with calcium citrate (CC) | Decreases - has been found to inhibit | bone loss | Animal | ovariectomized rats | — | Effect of Collagen Peptide, Alone and in Combination with Calcium Citrate, on Bone Loss in Tail-Suspended Rats. |
| Oral administration of bovine collagen peptide (CP) combined with calcium citrate (CC) | Decreases - has been found to inhibit | bone loss | Animal | ovariectomized rats | — | Effect of Collagen Peptide, Alone and in Combination with Calcium Citrate, on Bone Loss in Tail-Suspended Rats. |
| Oral administration of bovine collagen peptide (CP) combined with calcium citrate (CC) | Decreases - has been found to inhibit | bone loss | Animal | ovariectomized rats | — | Effect of Collagen Peptide, Alone and in Combination with Calcium Citrate, on Bone Loss in Tail-Suspended Rats. |
| vitamin D and calcium supplementation | Decreases - attenuate | bone loss | Human | — | Not specified. | The effects of popular diets on bone health in the past decade: a narrative review.cited 4× |
| a high calcium diet | Decreases - recommended to prevent | bone loss | Human | during inadequate calcium intake | Not specified | Site-Specific Onset of Low Bone Density and Correlation of Bone Turnover Markers in Exclusive Breastfeeding Mothers.cited 5× |
| Calcium supplementation | Decreases - recommended to prevent | bone loss | Human | during inadequate calcium intake | Not specified | Site-Specific Onset of Low Bone Density and Correlation of Bone Turnover Markers in Exclusive Breastfeeding Mothers.cited 5× |
| Calcium supplementation | Decreases - optimal starting time should be before | bone loss | Human | — | Not specified | Site-Specific Onset of Low Bone Density and Correlation of Bone Turnover Markers in Exclusive Breastfeeding Mothers.cited 5× |
| calcium-collagen chelate (CC) dietary supplement | Decreases - reducing | bone loss | Human | postmenopausal women with osteopenia | — | A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial.cited 17× |
| combination of bisphosphonates and calcium supplementation | Decreases - is necessary to prevent | bone loss | Human | women who initially receive a weaker antiresorptive such as the SERM raloxifene | Not specified | Controversies in osteoporosis management: antiresorptive therapy for preventing bone loss: when to use one or two antiresorptive agents?cited 6× |
| high calcium milk powder supplementation | Decreases - was better in retarding bone loss than medium and low calcium | bone loss in the greater trochanter | Human | healthy postmenopausal women | 300, 600, and 900 mg/day of calcium (groups A, B, and C, respectively) with 800 IU/day of vitamin D. | Effect of Milk Powder Supplementation with Different Calcium Contents on Bone Mineral Density of Postmenopausal Women in Northern China: A Randomized Controlled Double-Blind Trial.cited 9× |
| calcium obtained either through the diet or in the form of medicinal supplementation | No effect - data regarding the efficacy ... is conflicting | prevention of bone loss and osteoporotic fractures | Human | the elderly | Not specified | Supplemental calcium intake in the aging individual: implications on skeletal and cardiovascular health.cited 11× |
| calcium alone | No effect - unlikely to be of benefit | prevention of bone loss and osteoporotic fractures | Human | the elderly | Not specified | Supplemental calcium intake in the aging individual: implications on skeletal and cardiovascular health.cited 11× |
| adequate calcium intake | Decreases - to modulate the rate of | age-associated bone loss | Human | — | Not specified | Supplemental calcium intake in the aging individual: implications on skeletal and cardiovascular health.cited 11× |
| Calcium supplementation | Decreases - reduce | bone loss | Human | older people | 1140 mg/day for white boys, 1300 mg/day for white girls. | Calcium and bone.cited 92× |
| Calcium | Decreases - plays a role in preventing | bone loss | Human | later life | 1140 mg/day for white boys, 1300 mg/day for white girls. | Calcium and bone.cited 92× |
| calcium supplementation | Decreases - exerts a small protective effect | bone loss | Human | postmenopausal women | Not specified | Effectiveness and safety of routine calcium supplementation in postmenopausal women. A narrative review.cited 1× |
| calcium supplementation | No effect - do not support routine | prevention of bone loss or bone fracture | Human | all postmenopausal women | Not specified | Effectiveness and safety of routine calcium supplementation in postmenopausal women. A narrative review.cited 1× |
| calcium supplementation | No effect - disappears after cessation | protective effect against bone loss | Human | postmenopausal women | Not specified | Effectiveness and safety of routine calcium supplementation in postmenopausal women. A narrative review.cited 1× |
| calcium supplementation | Decreases - may be mitigated | bone loss and increased fracture risk during intentional weight loss | Human | — | Not specified | Weight Loss Interventions and Skeletal Health in Persons with Diabetes.cited 7× |
| combined oral administration of bovine CPs with calcium citrate | Decreases - inhibits | bone loss | Animal | OVX rats | — | Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. |
| combined oral administration of bovine CPs with calcium citrate | Decreases - is a promising alternative for reducing | bone loss | Animal | osteopenic postmenopausal women | — | Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. |
| CP-calcium citrate | Decreases - significantly inhibited | bone loss | Animal | OVX rats | — | Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. |
| CP-calcium citrate | Decreases - prevented | trabecular bone loss | Animal | OVX rats | — | Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. |
| 20,000 IU vitamin D(3) once a week and 500 mg calcium daily | No effect - did not prevent | bone loss | Human | ambulatory persons with MS age 18-50 years | 500 mg calcium daily. | Can vitamin D supplementation prevent bone loss in persons with MS? A placebo-controlled trial.cited 43× |
| supplementation of vitamin D and calcium | Decreases - can prevent | the bone loss seen with specific ART regimens | Human | — | Not specified | HIV and its effects on bone: a primer for rheumatologists.cited 10× |
| Calcium supplementation along with alfacalcidol | Decreases - can prevent further bone loss to a greater extent than menatetrenone | bone loss | Human | children treated with long-term glucocorticoids | 400 mg of elemental calcium daily. | Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone.cited 8× |
| calcium and vitamin D supplementation | Decreases - may be employed to abrogate bone loss | bone loss | Human | this patient group | Not specified | Bone loss in HIV: a contemporary review.cited 47× |
| Calcium and vitamin D supplementation | Decreases - may attenuate | bone loss | Human | people living with HIV (PLWH) at ART initiation | Not specified | Osteoporosis and HIV Infection.cited 48× |
| calcium and vitamin D supplementation | Affects - is recommended | Cancer treatment-induced bone loss (CTBL) | Human | null | Not specified | Cancer treatment-induced bone loss.cited 3× |
| calcium and vitamin D supplementation | Decreases - may be beneficial to counterbalance | substantial bone loss | Human | patients following transplantation | — | Low-dose pamidronate for treatment of early bone loss following kidney transplantation: a randomized controlled trial.cited 4× |
| Calcium | Decreases - play an important role in preventing | bone loss | Human | — | Not specified | The Effects of Different Dietary Patterns on Bone Health.cited 10× |
| Calcium plus vitamin D supplementation | Decreases - reduced bone loss | bone loss | Human | pregnant Brazilian adolescents with habitually low calcium intake | 600 mg/d calcium plus 200 IU/d cholecalciferol. | Reduction in Bone Loss from 5 to 20 Weeks Postpartum in Adolescents Supplemented with Calcium Plus Vitamin D during Pregnancy Is Not Sustained at 1 Year Postpartum: Follow-up Study of a Randomized Controlled Trial.cited 5× |
| Calcium plus vitamin D supplementation | Decreases - reduces the magnitude of bone loss | bone loss at the femoral neck | Human | adolescent mothers | 600 mg/d calcium plus 200 IU/d cholecalciferol. | Reduction in Bone Loss from 5 to 20 Weeks Postpartum in Adolescents Supplemented with Calcium Plus Vitamin D during Pregnancy Is Not Sustained at 1 Year Postpartum: Follow-up Study of a Randomized Controlled Trial.cited 5× |
| calcium plus vitamin D supplementation | Decreases - a reduced rate of | femoral neck bone loss | Human | adolescents with low calcium intake | 600 mg calcium + 200 IU vitamin D3 daily. | Effect of calcium plus vitamin D supplementation during pregnancy in Brazilian adolescent mothers: a randomized, placebo-controlled trial.cited 48× |
| calcium plus vitamin D supplementation | No effect - interacted with polymorphisms in the VDR gene promoter region affecting postpartum bone loss | postpartum bone loss | Human | — | 600 mg/d calcium + 200 IU/d cholecalciferol. | Calcium plus vitamin D supplementation during pregnancy interacts with polymorphisms in the promoter region of the VDR gene to affect postpartum bone mass of Brazilian adolescent mothers: A randomized controlled trial.cited 9× |
| calcium plus vitamin D supplementation | Decreases - appeared to minimize postpartum bone loss | postpartum bone loss | Human | adolescents with 1521 GG/1012 AA | 600 mg/d calcium + 200 IU/d cholecalciferol. | Calcium plus vitamin D supplementation during pregnancy interacts with polymorphisms in the promoter region of the VDR gene to affect postpartum bone mass of Brazilian adolescent mothers: A randomized controlled trial.cited 9× |
| diet rich of calcium and vitamin D | No effect - include | prevention and treatment of bone loss | Human | — | Not specified | Current and Emerging Strategies in Osteoporosis Management.cited 6× |