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Calcium and bone.

Clinical biochemistry
August 1, 2012
Kun Zhu et al. (2 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to evaluate the role of calcium on bone health, focusing on its impact during growth and its preventive effects on bone loss and fractures in later life.

Results Summary

Calcium intake influences skeletal calcium retention during growth, affecting peak bone mass, and helps prevent bone loss and osteoporotic fractures in older age. Meta-analyses indicate calcium supplementation reduces bone loss by 0.5-1.2% and fracture risk by at least 10% in older populations.

Population

Children, adults, and older individuals across various ethnic groups.

Effective Dosage

1140 mg/day for white boys, 1300 mg/day for white girls.

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
Calcium intake
increase
skeletal calcium retention during growth
-
-
influences
#1
Calcium intake
increase
peak bone mass achieved in early adulthood
-
-
affects
#2
Increased calcium intake
increase
bone mineral accretion rate
all ethnic groups
up to a threshold level
is associated with increased
#3
Calcium
decrease
bone loss
later life
-
plays a role in preventing
#4
Calcium
decrease
osteoporotic fractures
later life
-
plays a role in preventing
#5
Calcium supplementation
decrease
bone loss
older people
0.5-1.2%
reduce
#6
Calcium supplementation
decrease
the risk of fracture of all types
older people
at least 10%
reduce
#7
Abstract

OBJECTIVE: Evaluate the role of calcium on bone health. METHODS: Review of literatures on calcium and bone development during childhood and bone health in adulthood and older age. RESULTS: Calcium intake influences skeletal calcium retention during growth and thus affects peak bone mass achieved in early adulthood. Increased calcium intake is associated with increased bone mineral accretion rate up to a threshold level in all ethnic groups. The minimum intake to achieve maximal retention is 1140 mg/day for white boys and 1300 mg/day for white girls. Calcium also plays a role in preventing bone loss and osteoporotic fractures in later life. Meta-analyses report that calcium supplementation reduce bone loss by 0.5-1.2% and the risk of fracture of all types by at least 10% in older people. Low calcium intake is a widespread problem across countries and age groups. CONCLUSION: Adequate calcium intake throughout lifetime is important for bone health and the prevention of osteoporosis and related fractures.

Medical Subject Headings (MeSH)
AgingBone DevelopmentBone and BonesCalcification, PhysiologicCalciumDietDietary SupplementsFractures, BoneHumansOsteoporosisRandomized Controlled Trials as Topic
Study Links
Quality Scores
SafetyNot Assessed
Efficacy85/10
Quality75/10
Citation Metrics
Total Citations92
Citations/Year7.1
Relative Citation Ratio3.39
NIH Percentile87.4%
Research Impact Scores
APT Score0.75
Weight Score1.53
Normalized Score0.69
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