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The effects of popular diets on bone health in the past decade: a narrative review.

Frontiers in endocrinology
January 1, 2023
Yue Peng et al. (4 authors)
ReviewJournal ArticleResearch Support, Non-U.S. Gov'tHuman Study
Study Details

Study Goal

The researchers aimed to review the effects of popular diets (including KD, MD, CR, HP, and IF) on bone health, with a focus on calcium metabolism and bone quality.

Results Summary

The review found that KD and CR diets may negatively impact bone health by disrupting calcium metabolism, while MD and HP diets showed protective effects. Adequate vitamin D and calcium supplementation, along with exercise, were suggested to mitigate bone loss in CR diets.

Population

General population (no specific demographic mentioned).

Effective Dosage

Not specified.

Duration

Not specified.

Interactions

None mentioned.

Extracted Claims (14)
InterventionDirectionEndpointPopulationDosageImpactClaim #
ketogenic diet (KD)
decrease
bone health
-
-
detrimental effects
#1
ketogenic diet (KD)
decrease
bone quality
-
-
interrupts energy balance and calcium metabolism
#2
Ginsenoside-Rb2
decrease
bone loss
-
-
attenuate
#3
metformin
decrease
bone loss
-
-
attenuate
#4
simvastatin
decrease
bone loss
-
-
attenuate
#5
caloric restriction (CR)
decrease
bone health
-
-
detrimental effects
#6
caloric restriction (CR)
decrease
bone loss
-
-
influences energy imbalance, glucocorticoid levels, and adipose tissue
#7
vitamin D and calcium supplementation
decrease
bone loss
-
-
attenuate
#8
exercise training
decrease
bone loss
-
-
attenuate
#9
Mediterranean diet (MD)
increase
bone health
-
-
protective effects
#10
olive oil
increase
bone health
-
-
protects
#11
high-protein diet (HP)
increase
bone health
-
-
protective effects
#12
intermittent fasting (IF)
decrease
bone health
animal studies
-
detrimental effects
#13
intermittent fasting (IF)
no change
bone health
human studies
-
not shown detrimental effects
#14
Abstract

Bone health encompasses not only bone mineral density but also bone architecture and mechanical properties that can impact bone strength. While specific dietary interventions have been proposed to treat various diseases such as obesity and diabetes, their effects on bone health remain unclear. The aim of this review is to examine literature published in the past decade, summarize the effects of currently popular diets on bone health, elucidate underlying mechanisms, and provide solutions to neutralize the side effects. The diets discussed in this review include a ketogenic diet (KD), a Mediterranean diet (MD), caloric restriction (CR), a high-protein diet (HP), and intermittent fasting (IF). Although detrimental effects on bone health have been noticed in the KD and CR diets, it is still controversial, while the MD and HP diets have shown protective effects, and the effects of IF diets are still uncertain. The mechanism of these effects and the attenuation methods have gained attention and have been discussed in recent years: the KD diet interrupts energy balance and calcium metabolism, which reduces bone quality. Ginsenoside-Rb2, metformin, and simvastatin have been shown to attenuate bone loss during KD. The CR diet influences energy imbalance, glucocorticoid levels, and adipose tissue, causing bone loss. Adequate vitamin D and calcium supplementation and exercise training can attenuate these effects. The olive oil in the MD may be an effective component that protects bone health. HP diets also have components that protect bone health, but their mechanism requires further investigation. In IF, animal studies have shown detrimental effects on bone health, while human studies have not. Therefore, the effects of diets on bone health vary accordingly.

Medical Subject Headings (MeSH)
HumansBone DensityDiet, KetogenicBone and BonesCaloric RestrictionDietAnimalsDiet, Mediterranean
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality80/10
Citation Metrics
Total Citations4
Citations/Year4.0
Research Impact Scores
APT Score0.75
Weight Score1.32
Normalized Score0.66
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