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Evidence suggests Melatonin maydecreasePain.
10 studies (8 claims)
Exact normalized-entity scope. Exact scope. Claims must match the selected normalized intervention and endpoint IDs; signal links are not expanded. Direction describes the stored endpoint phrase and is not a benefit/harm judgement.
8 of 10
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin | Decreases - has analgesic effects | pain | Human | clinical studies undertaken during surgery | Not specified | Melatonin and its agonists in pain modulation and its clinical application. |
| melatonin | Decreases - indicate significant analgesic effects | pain | Human | humans | Not specified in the abstract. | The analgesic effects of exogenous melatonin in humans.cited 13× |
| melatonin | Decreases - relieves | pain | Animal | — | — | Melatonin impedes Tet1-dependent mGluR5 promoter demethylation to relieve pain. |
| melatonin | Decreases - decreased | pain | Human | women with primary dysmenorrhea | Not specified | Both melatonin and meloxicam improved sleep and pain in females with primary dysmenorrhea-results from a double-blind cross-over intervention pilot study.cited 9× |
| melatonin | Decreases - has pain-killing properties | pain | Human | — | Not specified | Melatonin and morphine: potential beneficial effects of co-use.cited 31× |
| melatonin (MLT) | No effect - had no significant effect on | pain | Human | patients with cancer | — | Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials.cited 10× |
| melatonin (3 mg of melatonin into 2 ml of 2% hydroxyethyl cellulose gel packed into the socket) | Decreases - statistically significant improvement | pain | Human | patients who required removal of the impacted mandibular third molar | — | The Effect of Local Melatonin Application Following the Removal of an Impacted Mandibular Third Molar.cited 5× |
| Melatonin (MLT) | Decreases - recent studies suggest analgesic effects | pain | HumanAnimal | — | — | Melatonin Induces Analgesic Effects through MT |