Activation of spinal melatonin MT
European journal of pharmacology
January 1, 1970
Crystell G Guzmán-Priego et al. (9 authors)
Journal ArticleAnimal Study
Extracted Claims (5)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
melatonin | decrease | evoked pain | female neuropathic mice | - | reduced | #1 |
melatonin | decrease | spontaneous pain | female neuropathic mice | - | reduced | #2 |
melatonin | decrease | evoked pain | male neuropathic mice | - | reduced | #3 |
melatonin | decrease | spontaneous pain | male neuropathic mice | - | reduced | #4 |
melatonin | increase | antiallodynic effect | female neuropathic mice | - | significantly greater effect | #5 |
Abstract
Previous studies have reported the effects of melatonin mainly in male rodents. However, the effect of sex on the effect of melatonin remains unknown. The purpose of this study was to evaluate the role of sex in the antiallodynic effect of melatonin under neuropathic pain conditions. Intrathecal melatonin reduced both evoked and spontaneous pain in female and male neuropathic mice, with a significantly greater effect in female mice. Selective blockade of spinal melatonin MT
Medical Subject Headings (MeSH)
AnimalsMaleFemaleReceptor, Melatonin, MT2MelatoninMiceNeuralgiaSpinal CordSex CharacteristicsOvariectomyEstradiolHyperalgesia
Study Links
PubMed ID40752763
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