Melatonin
→Oxidative balance

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Evidence suggests Melatonin mayincreaseOxidative balance.

14 studies (11 claims)

Moderate consensus

Typical effective dose 5 (4–5.5) mgacross 3 dosed studies

Study Claims

13 of 16

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
melatonin	Increases - restores	autophagic balance	AnimalMolecular	—	Not specified.	Melatonin Ameliorates Heat Stress-Induced Oxidative Apoptosis in Mouse Spermatocytes via Autophagy and Ferroptosis Pathways.
melatonin	Increases - shifts the balance between the sympathetic and parasympathetic system in favor of the parasympathetic system	balance between the sympathetic and parasympathetic system	Human	CNS	Not specified	Peripheral and central effects of melatonin on blood pressure regulation.
melatonin	Increases - shifts the balance between the sympathetic and parasympathetic system in favor of the parasympathetic system	balance between the sympathetic and parasympathetic system	Human	CNS	Not specified	Peripheral and central effects of melatonin on blood pressure regulation.
melatonin	Increases - responsible for establishment of adequate energy balance	energy balance	Human	—	Not specified	Melatonin, energy metabolism, and obesity: a review.cited 378×
melatonin	No effect - did not affect	postural balance	Human	postmenopausal women with osteopenia	1 mg or 3 mg nightly.	The effect of melatonin treatment on postural stability, muscle strength, and quality of life and sleep in postmenopausal women: a randomized controlled trial.cited 41×
melatonin	No effect - to influence	the balance between luteotrophic and luteolytic factors	HumanMolecular	human luteal cells from normally menstruating women (25-38 years old) in the midluteal phase	—	"Hormone of darkness" and human reproductive process: direct regulatory role of melatonin in human corpus luteum.
Melatonin	No effect - modulation of immune responses by regulation of	the T helper 1/2 balance and cytokine production	Human	—	Not specified	Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases.cited 73×
melatonin 5 mg	Increases - helps to restore	centrally mediated metabolic balance	Human	SGA-treated patients	5 mg nightly.	Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial.cited 86×
Pretreatment with melatonin (10 mg/kg)	Decreases - Reduction in	mitochondrial dynamic balance	Animal	prediabetic obese rats	—	Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats.
Melatonin used at high doses	No effect - affects	Bax/Bcl protein balance	Molecular	pancreatic carcinoma cell line (PANC-1)	High doses (specific amounts not stated) for pro-apoptotic effects; low doses for anti-apoptotic effects.	Melatonin influences pancreatic cancerogenesis.cited 18×
intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation	Increases - improved	postural balance parameters in eyes open and eyes closed conditions	Human	hemodialysis (HD) patients	Not specified	Effects of intradialytic exercise in combination with melatonin supplementation on functional capacity, postural balance, and quality of life in hemodialysis patients.cited 2×
intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation	Increases - improved	postural balance parameters in the dual task condition	Human	hemodialysis (HD) patients	Not specified	Effects of intradialytic exercise in combination with melatonin supplementation on functional capacity, postural balance, and quality of life in hemodialysis patients.cited 2×
melatonin supplementation	Increases - had a positive effect	static and dynamic balance	Human	trained male collegiate student-athletes	6 mg administered orally 30 minutes before testing.	Melatonin supplementation improves psychomotor and physical performance in collegiate student-athletes following a sleep deprivation night.cited 27×