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22
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Evidence suggests Magnesium maydecreasePain.
20 studies (34 claims)
Moderate consensus
Typical effective dose 200 (200–200) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| magnesium supplementation during general anaesthesia | No effect - had no significant effects on | postoperative pain | Human | children undergoing strabismus surgery | — | Effect of magnesium supplementation on emergence delirium and postoperative pain in children undergoing strabismus surgery: a prospective randomised controlled study.cited 8× |
| magnesium supplementation | No effect - did not differ significantly | pain score | Human | children aged 2 to 5 years who underwent strabismus surgery | — | Effect of magnesium supplementation on emergence delirium and postoperative pain in children undergoing strabismus surgery: a prospective randomised controlled study.cited 8× |
| Supplementation with adenosine triphosphate and magnesium sulfate | Decreases - provides an avenue to decrease | postoperative pain and opioid consumption | Human | — | Not specified | Nutritional Considerations in Hip and Knee Arthroplasty: A Critical Analysis of Current Evidence. |
| Oral magnesium | No effect - evidence was inconclusive | intensity of pain | Human | pregnant women | Not available | Interventions for leg cramps in pregnancy.cited 20× |
| CoQ10, tryptophan, and magnesium supplementation | Decreases - significantly decreased | pain intensity | Human | patients with FM | Not specified in the abstract. | Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial. |
| high-intensity interval training and vitamin B12 + magnesium supplementation (HIIT + Supp) | Decreases - could ameliorate | migraine pain | Human | — | Not specified for HIIT; supplementation included vitamin B12 and magnesium (amounts not detailed). | Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial.cited 10× |
| single-dose intra-articular (IA) magnesium (Mg) | Decreases - exhibited a significantly lower pain score | pain score | Human | patients after arthroscopic surgery | Single-dose intra-articular (specific dosage not mentioned). | Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and meta-analysis.cited 12× |
| intranasal fentanyl and intravenous magnesium | Increases - more participants in the intervention arm underwent pain | pain at the drug delivery site | Human | pediatric patients with sickle-cell anemia | Not specified | Analgesic management of uncomplicated acute sickle-cell pain crisis in pediatrics: a systematic review and meta-analysis.cited 3× |
| oral magnesium supplementation | No effect - secondary outcomes will be | pain relief | Human | patients | Magnesium oxide (specific dosage not mentioned). | MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol.cited 5× |
| oral magnesium supplementation | Decreases - efficacy in controlling | severe pain | Human | patients with advanced PAOD | Magnesium oxide (specific dosage not mentioned). | MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol.cited 5× |
| oral magnesium supplementation | Decreases - secondary outcomes will be | time needed to achieve a pain reduction | Human | patients | Magnesium oxide (specific dosage not mentioned). | MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol.cited 5× |
| magnesium | Decreases - exerts analgaesic effects | acute postoperative pain | Human | patients | Magnesium oxide (specific dosage not mentioned). | MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol.cited 5× |
| magnesium | Decreases - exerts analgaesic effects | neuropathic chronic pain | Human | patients | Magnesium oxide (specific dosage not mentioned). | MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol.cited 5× |
| magnesium | Decreases - exerts analgaesic effects | pain | Human | several animal pain models | Magnesium oxide (specific dosage not mentioned). | MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol.cited 5× |
| magnesium | No effect - can modulate pain | pain | Human | patients with peripheral arterial occlusive disease (PAOD) | Magnesium oxide (specific dosage not mentioned). | MAGnesium-oral supplementation to reduce PAin in patients with severe PERipheral arterial occlusive disease: the MAG-PAPER randomised clinical trial protocol.cited 5× |
| magnesium and malic acid | No effect - makes little or no difference | pain | Human | patients with fibromyalgia | — | Magnesium and malic acid supplement for fibromyalgia.cited 7× |
| magnesium supplementation | Increases - poorly tolerated, causing | abdominal pain and diarrhea | Human | most patients | — | The Dietary Approach to the Treatment of the Rare Genetic Tubulopathies Gitelman's and Bartter's Syndromes.cited 6× |
| oral magnesium-L-Threonate (L-TAMS) | No effect - did not affect | pain and emotional behaviors | Animal | sham rats | Not specified | Role of magnesium-L-Threonate in alleviating skin/muscle incision and retraction induced mechanical allodynia and anxiodepressive-like behaviors in male rats.cited 2× |
| A fixed-dose Andrographis paniculata, CoQ10, riboflavin, and magnesium | Decreases - significant effect was observed | pain intensity | Human | MO group | — | An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache.cited 13× |
| A fixed-dose Andrographis paniculata, CoQ10, riboflavin, and magnesium | Decreases - significant effect was observed | pain intensity | Human | MO group | — | An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache.cited 13× |
| A fixed-dose Andrographis paniculata, CoQ10, riboflavin, and magnesium | Decreases - showed a significant treatment effect | pain intensity | Human | MA group | — | An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache.cited 13× |
| A fixed-dose Andrographis paniculata, CoQ10, riboflavin, and magnesium | Decreases - efficacy persisted | pain intensity | Human | MA group | — | An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache.cited 13× |
| A fixed-dose Andrographis paniculata, CoQ10, riboflavin, and magnesium | No effect - did not report significant improvement | pain intensity | Human | TTH patients | — | An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache.cited 13× |
| Magnesium oral supplementation | No effect - resulted in | no relapse of pain | Human | 53-year-old man, liver transplant 10 months earlier | Not specified | Calcium pyrophosphate deposition (CPPD) in a liver transplant patient: are hypomagnesemia, tacrolimus or both guilty? A case-based literature review. |
| magnesium | Decreases - deserve more careful attention | pain | Human | patients with chronic postoperative pain (CPSP) | Not specified | Non-drug pain relievers active on non-opioid pain mechanisms. |
| magnesium | Decreases - deserve more careful attention | pain | Human | patients with chronic postoperative pain (CPSP) | Not specified | Non-drug pain relievers active on non-opioid pain mechanisms. |
| magnesium hydroxide | No effect - will be assessed for | pain scores | Human | patients with incurable cancer starting with opioids for pain management | Not specified in the abstract. | Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study).cited 1× |
| magnesium sulfate | Decreases - significantly reduced | pain | Human | patients with unilateral lower limb radiculopathy due to lumbar disc prolapse | 200 mg magnesium sulfate (single dose, epidural injection). | Transforaminal lumbar epidural injection of dexmedetomidine versus magnesium sulfate combined with dexamethasone for lower limb radicular pain management: a randomized, clinical trial. |
| magnesium sulfate | Decreases - significantly reduced | pain intensity | Human | patients with unilateral lower limb radiculopathy due to lumbar disc prolapse | 200 mg magnesium sulfate (single dose, epidural injection). | Transforaminal lumbar epidural injection of dexmedetomidine versus magnesium sulfate combined with dexamethasone for lower limb radicular pain management: a randomized, clinical trial. |
| magnesium sulfate | Decreases - demonstrated significant improvement | pain scores | Human | patients with unilateral lower limb radiculopathy due to lumbar disc prolapse | 200 mg magnesium sulfate (single dose, epidural injection). | Transforaminal lumbar epidural injection of dexmedetomidine versus magnesium sulfate combined with dexamethasone for lower limb radicular pain management: a randomized, clinical trial. |
| magnesium sulfate | Decreases - reduced | postoperative pain | Human | obese patients undergoing sleeve gastrectomy operations | Not specified | Magnesium Sulfate Reduced Opioid Consumption in Obese Patients Undergoing Sleeve Gastrectomy: a Prospective, Randomized Clinical Trial.cited 22× |
| sequential intravenous and oral magnesium infusion | Decreases - significant reduction | pain intensity | Human | patients with chronic low back pain with a neuropathic component | Intravenous magnesium infusion for 2 weeks followed by oral magnesium capsules for 4 weeks (exact dosage not specified). | A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component.cited 40× |
| 2-week intravenous magnesium infusion followed by 4 weeks of oral magnesium supplementation | Decreases - reduce | pain intensity | Human | patients with refractory chronic low back pain with a neuropathic component | Intravenous magnesium infusion for 2 weeks followed by oral magnesium capsules for 4 weeks (exact dosage not specified). | A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component.cited 40× |
| magnesium-L-threonate | No effect - reported chronic pain | chronic pain incidence | Human | patients | Not specified in the abstract. | A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery.cited 1× |
| magnesium-L-threonate | No effect - did not show improvement | pain | Human | patients who underwent breast cancer procedure | Not specified in the abstract. | A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery.cited 1× |
| magnesium-L-threonate | No effect - did not provide sufficient pain relief | pain relief | Human | breast cancer survivors | Not specified in the abstract. | A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery.cited 1× |
| magnesium-L-threonate | No effect - did not effectively prevent the development of persistent pain | persistent pain | Human | breast cancer survivors | Not specified in the abstract. | A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Therapeutic Effect of Magnesium-L-Threonate Supplementation for Persistent Pain After Breast Cancer Surgery.cited 1× |
| highly mineralized sulfate-bicarbonate sodium-magnesium water | Decreases - improves the elimination | dyspepsia and pain syndromes | Human | patients with GERD | Not specified | Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease.cited 4× |