Magnesium Sulfate Reduced Opioid Consumption in Obese Patients Undergoing Sleeve Gastrectomy: a Prospective, Randomized Clinical Trial.
Study Goal
The researchers aimed to investigate whether magnesium sulfate could effectively manage postoperative pain and reduce opioid consumption in patients undergoing sleeve gastrectomy.
Results Summary
The study found that perioperative magnesium sulfate significantly reduced cumulative morphine consumption and pain scores compared to the control group, with no significant differences in sedation scores or demographics between groups.
Population
Eighty obese patients undergoing sleeve gastrectomy at a university hospital.
Effective Dosage
Not specified
Duration
Perioperative (before, during, and 24 hours after surgery)
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
magnesium sulfate | decrease | postoperative pain | obese patients undergoing sleeve gastrectomy operations | - | reduced | #1 |
magnesium sulfate | decrease | opioid consumption | obese patients undergoing sleeve gastrectomy operations | - | reduced | #2 |
- | increase | Cumulative morphine consumption | control group | - | were found to be higher | #3 |
- | increase | pain scores | control group | - | were found to be higher | #4 |
OBJECTIVE: The purpose of the study was to investigate the effect of magnesium sulfate on pain management for pain after sleeve gastrectomy operation. DESIGN: A prospective, randomized, placebo-controlled clinical study. SETTING: University hospital. PARTICIPANTS: Eighty patients undergoing sleeve gastrectomy. MEASUREMENTS AND MAIN RESULTS: Visual analog scale for the evaluation of pain, sedation score, mean arterial pressure, heart rate, and total analgesic consumption was recorded. Serum magnesium levels were determined before the operation, at the end of the operation, and at 24 h. There were no significant differences between the groups with respect to demographics, and sedation scores. Cumulative morphine consumption and pain scores were found to be higher in the control group than the magnesium group. CONCLUSION: Perioperative use of magnesium sulfate reduced postoperative pain and opioid consumption in obese patients undergoing sleeve gastrectomy operations.