Panacea Index Logo

Command Palette

Search for a command to run...

The Dietary Approach to the Treatment of the Rare Genetic Tubulopathies Gitelman's and Bartter's Syndromes.

Nutrients
January 1, 1970
Francesco Francini et al. (7 authors)
Journal ArticleReviewHuman Study
Extracted Claims (7)
InterventionDirectionEndpointPopulationDosageImpactClaim #
potassium, sodium, chloride, and magnesium supplementation
neutral
Gitelman's (GS) and Bartter's (BS) syndromes
patients with GS and BS
-
treatment based on
#1
potassium and magnesium-rich foods and supplements
increase
potassium and magnesium intake
GS and BS patients
-
increase
#2
some foods
decrease
potassium and magnesium plasma level
GS and BS patients
-
reduce
#3
magnesium supplementation
increase
abdominal pain and diarrhea
most patients
-
poorly tolerated, causing
#4
new formulations using liposome and sucrosomial technology
neutral
magnesium supplementation
-
-
proposed for
#5
new formulations using liposome and sucrosomial technology
increase
magnesium supplement tolerability and intestinal absorption
-
-
increase
#6
dietary approach
neutral
therapeutic approach to GS and BS
GS and BS patients
-
very important in
#7
Abstract

Gitelman's (GS) and Bartter's (BS) syndromes are rare, inherited autosomal recessive tubulopathies characterized by hypokalemia, metabolic alkalosis, renal sodium, chloride, and potassium and magnesium-wasting. While the treatment based on potassium, sodium, chloride, and magnesium supplementation in addition to other pharmacologic options are widely established, recommendations about the dietary approach to GS and BS still remain generic. In this review we focus on the dietary strategies to increase sodium, potassium, and magnesium intake in GS and BS patients. Potassium and magnesium-rich foods and supplements are considered together with those that may reduce through different mechanisms the potassium and magnesium plasma level. Magnesium supplementation is often poorly tolerated, causing abdominal pain and diarrhea in most patients. New formulations using liposome and, in particular, sucrosomial technology have been recently proposed for magnesium supplementation in order to increase magnesium supplement tolerability and intestinal absorption. The dietary approach to GS and BS may be very important in the therapeutic approach to these syndromes. Due to the relevance of the dietary approach to these syndromes, a nutritional counseling should always be recommended and the nutritionist should join nephrologists in the follow-up of GS and BS patient care.

Medical Subject Headings (MeSH)
Bartter SyndromeDietGitelman SyndromeHumansMagnesiumPotassium, DietarySodium, Dietary
Study Links
Citation Metrics
Total Citations6
Citations/Year1.5
Relative Citation Ratio0.60
NIH Percentile32.4%
Research Impact Scores
APT Score0.25
Related Supplements
The Dietary Approach to the Treatment of the Rare Genetic Tu... | Panacea Index