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Evidence suggests Magnesium maydecreaseAnxiety.
13 studies (11 claims)
Moderate consensus
Typical effective dose 374 (311–437) mgacross 2 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| magnesium and zinc | Decreases - significantly reduced | Beck Anxiety Inventory (BAI) | Human | patients suffering from coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) | — | The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease.cited 41× |
| magnesium orotate | No effect - adding | psychiatric disorders' treatment, such as major depression and anxiety | Human | — | Not specified | Magnesium Orotate and the Microbiome-Gut-Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders.cited 20× |
| Combined magnesium and vitamin B6 supplementation | Decreases - reduced | premenstrual anxiety | Human | women | Not specified | The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review.cited 24× |
| Magnesium and vitamin B6 | No effect - had no effect | anxiety | Human | women when used in isolation | Not specified | The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review.cited 24× |
| Magnesium-containing supplements | Decreases - may hold promise | anxiety | Human | — | Not specified | Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review.cited 90× |
| Consumption of magnesium chloride for 6 weeks | Decreases - resulted in a net improvement | Generalized Anxiety Disorders-7 scores | Human | 112 participants | 248 mg of elemental magnesium per day. | Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.cited 68× |
| magnesium supplementation | Decreases - significantly lower | mean level of anxiety and depression | Human | patients after open-heart surgery | 500 mg daily (two 250-mg magnesium oxide tablets). | Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery.cited 9× |
| Magnesium administered contemporarily with low-dose NMDA antagonists | Decreases - has been shown to cause a reduction in | anxiety-related and depressive-like behaviours | Human | — | Not specified | Magnesium level and impulsivity during ketamine administration for treatment-resistant mood disorders. |
| magnesium | Decreases - less anxiety | anxiety symptoms or disorder prevalence | Human | — | Not specified | Diet and Anxiety: A Scoping Review.cited 92× |
| a dietary supplement formulated with bioactive peptides from a fish protein hydrolysate (Gabolysat®), magnesium and vitamin B6 | Decreases - the anxiety of 75.3% of patients improved significantly and very significantly | anxiety | Human | patients | Not specified (28-day treatment with dietary supplement). | Effect of a Dietary Supplement Combining Bioactive Peptides and Magnesium on Adjustment Disorder with Anxiety: A Clinical Trial in General Practice.cited 6× |
| Supplementation with a fixed combination of feverfew, coenzyme Q10 and magnesium (Antemig®, PiLeJe) | Decreases - decreased | proportion of patients with anxiety and depressive symptoms (Hospital Anxiety and Depression Scale) | Human | Adult patients suffering from migraine | 100 mg Feverfew, 100 mg coenzyme Q10, and 112.5 mg magnesium per day. | A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study.cited 28× |
| combination of extracts of C. oxycantha, E. californica and magnesium | Decreases - were superior to placebo | generalized anxiety disorder severity | Human | adults with generalized anxiety disorder | Not specified | Complementary and Alternative Medicine Treatments for Generalized Anxiety Disorder: Systematic Review and Meta-analysis of Randomized Controlled Trials.cited 23× |