Effect of a Dietary Supplement Combining Bioactive Peptides and Magnesium on Adjustment Disorder with Anxiety: A Clinical Trial in General Practice.
Study Goal
The researchers aimed to evaluate the efficacy of a dietary supplement containing bioactive peptides from fish protein hydrolysate (Gabolysat®), magnesium, and vitamin B6 in managing adjustment disorder with anxiety.
Results Summary
The study found that 41.9% of patients achieved a 50% reduction in Ham-A scores, with a mean decrease of 12.1 points. Additionally, 75.3% of patients showed significant improvement in anxiety according to the CGI scale, with limited side effects and negligible rebound effects.
Population
Patients diagnosed with adjustment disorder with anxiety (Ham-A score ≥20).
Effective Dosage
Not specified (28-day treatment with dietary supplement).
Duration
28 days.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
a dietary supplement formulated with bioactive peptides from a fish protein hydrolysate (Gabolysat®), magnesium and vitamin B6 | decrease | Ham-A score | Patients diagnosed as anxious with a score of ≥20 on the Hamilton Anxiety Rating Scale | 50% reduction | A 50% reduction in the Ham-A score, was achieved for 41.9% of the patients | #1 |
a dietary supplement formulated with bioactive peptides from a fish protein hydrolysate (Gabolysat®), magnesium and vitamin B6 | decrease | mean Ham-A score | Patients diagnosed as anxious with a score of ≥20 on the Hamilton Anxiety Rating Scale | 12.1 ± 5.7 points | The mean Ham-A score decreased by 12.1 ± 5.7 points | #2 |
a dietary supplement formulated with bioactive peptides from a fish protein hydrolysate (Gabolysat®), magnesium and vitamin B6 | decrease | anxiety | patients | 75.3% | the anxiety of 75.3% of patients improved significantly and very significantly | #3 |
Anxiety is a high frequency disorder in the general population. It is usually treated with benzodiazepines, which cause side effects and a dependence that could make withdrawal difficult. Alternative treatments are therefore needed to reduce the use of anxiolytics, particularly for adjustment disorder with anxiety. An observational, multicentre, prospective, longitudinal study has been conducted by general practitioners and one gynaecologist to evaluate the efficacy of a dietary supplement on adjustment disorder with anxiety (Stress 2 study). Patients diagnosed as anxious with a score of ≥20 on the Hamilton Anxiety Rating Scale (Ham-A, first visit on Day 0 (V0)) were offered a 28-day treatment with a dietary supplement formulated with bioactive peptides from a fish protein hydrolysate (Gabolysat®), magnesium and vitamin B6. At the second visit (V1), the Ham-A Rating Scale, the Patient Global Impression scale (PGI) and the Clinical Global Impressions scale (CGI) were administered. A 50% reduction in the Ham-A score, was achieved for 41.9% of the patients. The mean Ham-A score decreased by 12.1 ± 5.7 points (p < 0.001) between V0 (25.6 ± 3.8) and V1 (13.6 ± 6.0). Furthermore, according to the CGI scale, the anxiety of 75.3% of patients improved significantly and very significantly, with limited side effects and a negligible rebound effect. In conclusion, adjustment disorder with anxiety seems to be effectively managed by an alternative and safer solution than benzodiazepines.