Alcohol
→HDL cholesterol

9

1

1

↑9

↓1

—1

Evidence suggests Alcohol mayincreaseHDL cholesterol.

6 studies (11 claims)

Moderate consensus

Study Claims

9 of 11

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
alcohol	Increases - increased significantly	tissue (liver and kidney) cholesterol and triglycerides	Animal	rats	Not specified	Therapeutic role of Cuminum cyminum on ethanol and thermally oxidized sunflower oil induced toxicity.cited 23×
chronic and moderate alcohol intake	Increases - directed its flow toward C-21 steroids	cholesterol flow	Human	asymptomatic chronic and moderate alcoholics	Not specified	Moderate alcohol consumption in chronic form enhances the synthesis of cholesterol and C-21 steroid hormones, while treatment with Tinospora cordifolia modulate these events in men.cited 20×
chronic and moderate alcohol intake	Increases - increased	cholesterol synthesis	Human	asymptomatic chronic and moderate alcoholics	Not specified	Moderate alcohol consumption in chronic form enhances the synthesis of cholesterol and C-21 steroid hormones, while treatment with Tinospora cordifolia modulate these events in men.cited 20×
moderate alcohol intake	Increases - significant increase in the levels of	Cholesterol	Human	asymptomatic moderate alcoholics	Not specified	Protective Effects of Tinospora cordifolia on Hepatic and Gastrointestinal Toxicity Induced by Chronic and Moderate Alcoholism.cited 20×
Chronic moderate alcohol consumption	No effect - were indistinguishable from controls	cholesterol levels	HumanAnimal	inbred alcohol-preferring (iP10a) rats	—	A snapshot of the hepatic transcriptome: ad libitum alcohol intake suppresses expression of cholesterol synthesis genes in alcohol-preferring (P) rats.
Chronic moderate alcohol consumption	Decreases - led to down-regulation	nine genes in the cholesterol biosynthesis pathway	HumanAnimal	inbred alcohol-preferring (iP10a) rats	—	A snapshot of the hepatic transcriptome: ad libitum alcohol intake suppresses expression of cholesterol synthesis genes in alcohol-preferring (P) rats.
Long-term excessive alcohol feeding	Increases - indicating enhanced	cholesterol biosynthesis	AnimalMolecular	rats	—	Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver.
Long-term excessive alcohol feeding	Increases - associated with disrupted	cholesterol homeostasis	AnimalMolecular	rats	—	Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver.
Long-term excessive alcohol feeding	Increases - characterized by increased	hepatic cholesterol levels	AnimalMolecular	rats	—	Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver.