Nicotine
→Working memory

3

2

↑3

↓2

—0

Evidence suggests Nicotine mayincreaseWorking memory.

4 studies (5 claims)

Emerging evidence

Typical effective dose 0.1 (0.1–0.1) mgacross 1 dosed study

Study Claims

5 of 5

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
nicotine	Increases - improved	contextual fear memory	Animal	11-month-old DKO mice	100 μg/ml oral nicotine treatment	Age- and Genotype-Dependent Effects of Chronic Nicotine on Presenilin1/2 Double Knockout Mice: From Behavior to Molecular Pathways.
nicotine	Decreases - impaired	cued fear memory	Animal	11-month-old WT mice	100 μg/ml oral nicotine treatment	Age- and Genotype-Dependent Effects of Chronic Nicotine on Presenilin1/2 Double Knockout Mice: From Behavior to Molecular Pathways.
nicotine-ethanol abstinence	Decreases - induces	memory dysfunction	Animal	male Wistar rats	Not specified	Oral administration of coenzyme Q10 ameliorates memory impairment induced by nicotine-ethanol abstinence through restoration of biochemical changes in male rat hippocampal tissues.cited 3×
a combination of caffeine and nicotine	Increases - enhance	memory	Animal	male C57BL/6J mice	Caffeine (20 mg/kg) combined with nicotine (0.1 mg/kg).	The Effect of a Caffeine and Nicotine Combination on Nicotine Withdrawal Syndrome in Mice.
adolescent nicotine exposure followed by a period of drug cessation	Increases - exacerbates	behavioral indices of learning and memory	Animal	male Wistar rats	Not specified	Omega-3 fatty acids prevent nicotine withdrawal-induced impairment of learning and memory via affecting oxidative status, inflammatory response, cholinergic activity, BDNF and amyloid-B in rat hippocampal tissues.cited 9×