Omega-3 fatty acids prevent nicotine withdrawal-induced impairment of learning and memory via affecting oxidative status, inflammatory response, cholinergic activity, BDNF and amyloid-B in rat hippocampal tissues.
Study Goal
The researchers aimed to determine whether Omega-3 fatty acids could prevent the adverse effects of adolescent nicotine withdrawal on spatial and avoidance memory in male rats.
Results Summary
Omega-3 fatty acids significantly prevented nicotine withdrawal-induced adverse effects by restoring biochemical disturbances, including oxidative stress, inflammation, and neurotrophic capacity in hippocampal tissues. The study suggests Omega-3 fatty acids as a safe and effective therapeutic strategy for memory dysfunction associated with nicotine abstinence.
Population
Male Wistar rats (adolescent)
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
adolescent nicotine exposure followed by a period of drug cessation | increase | behavioral indices of learning and memory | male Wistar rats | - | exacerbates | #1 |
adolescent nicotine exposure followed by a period of drug cessation | increase | oxidative and inflammatory markers | male Wistar rats | - | lead to elevation of | #2 |
adolescent nicotine exposure followed by a period of drug cessation | decrease | neurotrophic capacity | male Wistar rats | - | reduction of | #3 |
adolescent nicotine exposure followed by a period of drug cessation | increase | AChE activity | male Wistar rats | - | increased | #4 |
co-administration of nicotine with Omega-3 fatty acids | decrease | nicotine withdrawal-induced adverse effects | male Wistar rats | - | significantly prevents | #5 |
co-administration of nicotine with Omega-3 fatty acids | neutral | the mentioned biochemical disturbances | male Wistar rats | - | restoration of | #6 |
Omega-3 fatty acids | decrease | the adverse effects of adolescent nicotine withdrawal on spatial and avoidance memory | male rats | - | prevent | #7 |
In the present study, the main objective was to reveal whether treatment by Omega-3 fatty acids could prevent the adverse effects of adolescent nicotine withdrawal on spatial and avoidance memory in male rats. For this purpose, Morris water maze and passive avoidance tests were performed on male Wistar rats and the hippocampal levels of oxidative stress markers, inflammatory indices, brain-derived neurotrophic factor, nitrite, amyloid-B and acetylcholinesterase (AChE) were measured. Moreover, density of dark neurons were assessed in CA1 and CA3 regions. Results showed that adolescent nicotine exposure followed by a period of drug cessation exacerbates the behavioral indices of learning and memory through affecting a variety of biochemical markers within the hippocampal tissues. These changes lead to elevation of oxidative and inflammatory markers, reduction of neurotrophic capacity and increased AChE activity in hippocampal tissues. In addition, it was observed that co-administration of nicotine with Omega-3 fatty acids significantly prevents nicotine withdrawal-induced adverse effects through restoration of the mentioned biochemical disturbances. Therefore, we suggest administration of Omega-3 fatty acids as a safe, inexpensive and effective therapeutic strategy for prevention of memory dysfunctions associated with nicotine abstinence during adolescence.