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6
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Evidence suggests Melatonin haslittle to no effecton Side effects.
13 studies (13 claims)
Typical dose 14 mg
Exact normalized-entity scope. Exact scope. Claims must match the selected normalized intervention and endpoint IDs; signal links are not expanded. Direction describes the stored endpoint phrase and is not a benefit/harm judgement.
12 of 13
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin | Increases - significantly more | side effects | Human | patients | Intra-operative intravenous infusion of 50 mg melatonin, followed by 10 mg melatonin orally for the first 3 nights after surgery. | No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial.cited 21× |
| melatonin | No effect - minimal to none | side effects | Human | null | Not specified | Melatonin in autism spectrum disorders: a systematic review and meta-analysis.cited 243× |
| melatonin | No effect - no or negligible side effects | side effects | Human | the majority of these studies | Not specified | Melatonin, a promising supplement in inflammatory bowel disease: a comprehensive review of evidences.cited 45× |
| melatonin | No effect - uncommon and mild | side effects | Human | — | Not specified | Melatonin Treatment in Children with Developmental Disabilities.cited 28× |
| melatonin | No effect - No significant side effects were observed | side effects | Human | patients with chronic CSCR | 3 mg melatonin t.i.d. (three times daily) | Therapeutic benefit of melatonin in refractory central serous chorioretinopathy.cited 33× |
| melatonin | Decreases - has advantages due to its low toxicity | side effects | Human | — | 25 mg melatonin. | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial.cited 16× |
| melatonin | No effect - no side effects | side effects | Human | — | Not specified | The neuroprotective role of melatonin in neurological disorders.cited 139× |
| melatonin | Decreases - alleviates | side effects | Human | radio/chemotherapy-treated patients | Not specified | The emergence of melatonin in oncology: Focus on colorectal cancer.cited 48× |
| melatonin | Decreases - acts by decreasing the side effects | side effects | Human | — | — | Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin. |
| melatonin | Decreases - well tolerated | side effects | Human | — | Not specified | Melatonin supplementation improves rheumatological disease activity: A systematic review.cited 4× |
| melatonin | Decreases - limit | side effects | Molecular | — | Not specified. | Melatonin modulates tumor metabolism and mitigates metastasis.cited 10× |
| melatonin (3 mg) | No effect - side effects attributable to melatonin were minimal | side effects | Human | IPD patients | 3 mg melatonin daily. | Melatonin on sleep in Parkinson's disease: A randomized double blind placebo controlled trial.cited 5× |