24
6
2
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↓6
—2
Evidence suggests Melatonin mayincreaseMetabolism.
63 studies (32 claims)
Moderate consensus
Typical effective dose 5 (4.5–8.75) mgacross 4 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| combination of 0.1 mg/L 1-MCP and 0.2 mM melatonin (MT) | Increases - exhibited a stronger regulation | active metabolism | Animal | mango fruit (Tainong No. 1) | 0.1 mg/L 1-MCP alone or combined with 0.2 mM melatonin (MT) | The Effects of Combined 1-Methylcyclopropene and Melatonin Treatment on the Quality Characteristics and Active Oxygen Metabolism of Mango Fruit during Storage.cited 4× |
| melatonin administration | No effect - regulating | lipid metabolism | Human | — | 5 mg melatonin tablets twice daily. | Effects of melatonin supplementation on metabolic parameters, oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: study protocol for a double-blind, randomized controlled trial.cited 1× |
| melatonin | Increases - may play an important role | body weight regulation and energy metabolism | Human | — | Not provided | Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities?cited 83× |
| Melatonin (MLT) | Increases - stimulates | bone metabolism | Human | — | Not available | Melatonin and cancer: current knowledge and its application to oral cavity tumours. |
| Melatonin (MLT) | Increases - stimulates | bone metabolism | Human | — | Not available | Melatonin and cancer: current knowledge and its application to oral cavity tumours. |
| melatonin | No effect - may affect | bone metabolism | HumanAnimalMolecular | — | Not specified | Melatonin and the skeleton.cited 66× |
| melatonin | Increases - stimulates | bone metabolism | Human | — | Not specified | A new perspective in Oral health: potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity. |
| melatonin | Increases - stimulates | bone metabolism | Human | — | Not specified | A new perspective in Oral health: potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity. |
| melatonin | No effect - influences | bone metabolism | Human | — | Not specified. | Melatonin, bone regulation and the ubiquitin-proteasome connection: A review.cited 48× |
| melatonin | Increases - has demonstrated a beneficial effect | bone metabolism | Human | — | Not available. | Melatonin having Therapeutic Bone Regenerating Capacity in Biomaterials.cited 4× |
| melatonin | No effect - has functions ascribed to it including | cyto/neuroprotection, immune modulation, and energy metabolism | Human | — | — | Melatonergic drugs in development. |
| melatonin | No effect - leading to a balanced energy metabolism | energy metabolism | Human | adult life | Not specified | New insights into the function of melatonin and its role in metabolic disturbances.cited 39× |
| melatonin | No effect - should be considered to adequately understand its physiological effects on the regulation of metabolism | regulation of metabolism | Human | humans | Not specified | New insights into the function of melatonin and its role in metabolic disturbances.cited 39× |
| melatonin | No effect - modulating energy metabolism | energy metabolism | Human | — | Not specified | Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders.cited 7× |
| melatonin | No effect - regulates | energy metabolism | Human | humans | — | No title available |
| melatonin | Increases - improves | energy metabolism | Human | critically ill patients | Not mentioned | Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.cited 159× |
| melatonin | No effect - impact | glucose and lipid metabolism before and after a late evening meal | Human | Nine healthy male participants (26 ± 1.3 years, BMI 24.8 ± 0.8 kg/m²) | Not available | The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males.cited 16× |
| melatonin | No effect - affects | hepatic glucose metabolism | Human | — | Not specified | Chronomedicine and type 2 diabetes: shining some light on melatonin.cited 44× |
| Melatonin | Decreases - inhibits | hypoxia-induced cancer cell survival, invasion, migration, and metabolism | Molecular | — | Not specified | Melatonin as a Therapeutic Agent for the Inhibition of Hypoxia-Induced Tumor Progression: A Description of Possible Mechanisms Involved.cited 13× |
| melatonin | Increases - improves | iron metabolism | Human | hemodialyzed patients | Not specified | Melatonin and renal protection: novel perspectives from animal experiments and human studies (review).cited 35× |
| melatonin | Increases - ameliorating | iron metabolism dysregulation | AnimalMolecular | — | Not specified. | Melatonin Ameliorates Heat Stress-Induced Oxidative Apoptosis in Mouse Spermatocytes via Autophagy and Ferroptosis Pathways. |
| melatonin | No effect - modulates | lipid metabolism | Molecular | — | Pharmacological doses mentioned (specific amounts not provided). | Melatonin in energy control: Circadian time-giver and homeostatic monitor.cited 7× |
| melatonin | No effect - review the evidence on the effect | lipid metabolism | Human | — | Not specified | The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis.cited 13× |
| melatonin | No effect - reprogramming the metabolism | metabolism of human GC | Human | human GC | — | The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors. |
| melatonin | Affects - changes in | metabolism of tumor cells | HumanMolecular | — | Not specified | Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization.cited 84× |
| melatonin | Increases - improves | myocardial cell metabolism | Human | diabetic patients | Not specified | New insights into the role of melatonin in diabetic cardiomyopathy.cited 14× |
| melatonin | No effect - regulates | nutrient metabolism | HumanAnimalMolecular | — | Not specified | Monoamines' role in islet cell function and type 2 diabetes risk.cited 5× |
| melatonin | No effect - influences | plants' metabolism | Human | plants | Not specified | Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases.cited 41× |
| melatonin | No effect - regulation | pro-survival signaling and tumor metabolism | HumanMolecular | — | Not specified | Melatonin for the prevention and treatment of cancer. |
| melatonin | No effect - regulation | pro-survival signaling and tumor metabolism | HumanMolecular | — | Not specified | Melatonin for the prevention and treatment of cancer. |
| melatonin | Increases - shows a positive profile | regulation of the metabolism | Human | human body | Not specified | Melatonin and its Relationships with Diabetes and Obesity: A Literature Review.cited 4× |
| Melatonin | No effect - differentially regulates | the cell cycle, cell survival, and metabolism | HumanMolecular | malignant cells in contrast to normal prostate epithelial cells | Not specified | The Potential Oncostatic Effects of Melatonin against Prostate Cancer. |
| Melatonin | No effect - differentially regulates | the cell cycle, cell survival, and metabolism | HumanMolecular | malignant cells in contrast to normal prostate epithelial cells | Not specified | The Potential Oncostatic Effects of Melatonin against Prostate Cancer. |
| melatonin | No effect - alter | tumor cell metabolism | Molecular | — | Not specified. | Melatonin modulates tumor metabolism and mitigates metastasis.cited 10× |
| nocturnal rise in melatonin | Increases - causes | solid tumors to redirect their metabolic phenotype from Warburg-type metabolism to mitochondrial oxidative phosphorylation | HumanMolecular | solid tumors | Not specified | Part-time cancers and role of melatonin in determining their metabolic phenotype.cited 17× |
| melatonin treatment | Increases - rescued | impairment of bioenergetics parameters in pAECs metabolism | AnimalMolecular | aortic endothelial cells (pAECs) | Not available | Melatonin rescues cell respiration impaired by hypoxia/reoxygenation in aortic endothelial cells and affects the mitochondrial bioenergetics targeting the F1FO-ATPase. |
| melatonin treatment (HFD-Mi + M) | Increases - improving | lipid metabolism | Animal | — | Not specified | Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics. |
| melatonin treatment | Increases - activated | tryptophan metabolism pathway | Animal | — | Not specified | Exogenous melatonin improves drought stress tolerance via regulating tryptophan metabolism and flavonoid biosynthesis pathways in wheat.cited 1× |
| myo-inositol plus melatonin | Increases - affects positively | glucose metabolism | Human | women during menopausal transition | 2 g myo-inositol twice daily (myo-Ins group) or 2 g myo-inositol plus 3 g melatonin daily (combination group). | Myo-inositol and melatonin in the menopausal transition.cited 24× |
| intraperitoneal injection of melatonin (40 mg/kg) | Decreases - effectively ameliorated | changes in ferroptosis-related indicators such as lipid peroxidation and iron metabolism | Animal | male SD rats with subarachnoid hemorrhage model | — | Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage. |
| melatonin supplementation at 10 μmol/L | Decreases - significantly downregulated | mRNA expression of lipid metabolism-related genes | AnimalMolecular | bovine mammary epithelial cells (BMECs) | — | Melatonin suppresses milk fat synthesis by inhibiting the mTOR signaling pathway via the MT1 receptor in bovine mammary epithelial cells. |
| melatonin and tryptophan | Increases - improve | some parameters of fat metabolism | Human | patients with NAFLD | 2 x 5 mg/day | Effects of treatment with melatonin and tryptophan on liver enzymes, parameters of fat metabolism and plasma levels of cytokines in patients with non-alcoholic fatty liver disease--14 months follow up.cited 109× |
| melatonin and the MT2/PI3K/LIF axis | Increases - enhancing | metabolism | AnimalMolecular | obese animals | — | Melatonin improves endometrial receptivity and embryo implantation via MT2/PI3K/LIF signaling pathway in sows. |
| magnesium and melatonin supplementation | No effect - effect on the markers of metabolism needs to be further verified | markers of metabolism | Human | — | — | The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolism in women with polycystic ovarian syndrome (PCOS): A systematic review.cited 5× |
| absence of melatonin during pregnancy | Decreases - impairs | glucose metabolism | Animal | rats | — | Melatonin regulates maternal pancreatic remodeling and B-cell function during pregnancy and lactation. |
| Resveratrol and melatonin | Increases - improve energy metabolism | energy metabolism | Molecular | — | Not provided. | The role and therapeutic potential of SIRTs in sepsis.cited 5× |
| Pineal melatonin suppression | Decreases - attenuates this | circadian "resetting" of mitochondrial metabolism | Molecular | — | Not provided | Melatonin: Roles in influenza, Covid-19, and other viral infections.cited 146× |
| oral melatonin administration | No effect - No evidence was found for an independent effect | markers of glucose metabolism | Human | menopausal women | 3 mg and above | Melatonin and the health of menopausal women: A systematic review.cited 16× |
| high concentration of melatonin | No effect - play an important role in the antitumoral effects | glucose metabolism and other related pathways | Molecular | — | Not specified (low and high concentrations mentioned, but exact amounts not provided). | Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration.cited 24× |