6
16
2
↑6
↓16
—2
Evidence suggests Melatonin maydecreaseBreast cancer.
18 studies (24 claims)
Moderate consensus
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| Disruption of the circadian nocturnal melatonin signal | Increases - promotes | growth, metabolism, and signaling of human breast cancer | Human | animal and human models | Not specified | Melatonin: A Potential Therapeutic Option for Breast Cancer.cited 38× |
| Melatonin | Decreases - has significant inhibitory effects | numerous cancers, especially breast cancer | Human | — | Not specified | Melatonin: A Potential Therapeutic Option for Breast Cancer.cited 38× |
| circadian disruption of melatonin synthesis | Increases - linked to increased breast cancer risk | breast cancer risk | Human | — | Not specified | Melatonin and breast cancer: Evidences from preclinical and human studies.cited 80× |
| melatonin | Decreases - inverse correlation | risk of breast cancer | Human | — | Not specified | Melatonin and breast cancer: Evidences from preclinical and human studies.cited 80× |
| melatonin alone or in combined administration | No effect - seems to be appropriate drug for the treatment | early stages of breast cancer | Human | — | Not specified | Melatonin and breast cancer: Evidences from preclinical and human studies.cited 80× |
| melatonin | Affects - changes in | biosynthesis of estrogen in breast cancer cells | HumanMolecular | breast cancer cells | Not specified | Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization.cited 84× |
| melatonin | Decreases - has the potential to prevent metastatic and invasive nature | breast cancer | Human | — | Not specified. | The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor.cited 28× |
| melatonin | Decreases - anti-metastatic effect | breast cancer | Human | — | Not specified. | The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor.cited 28× |
| melatonin | No effect - poorly documented to conclude on a positive effect | breast cancer | HumanMolecular | — | Not specified | Protective role of melatonin in breast cancer: what we can learn from women with blindness.cited 2× |
| melatonin | Decreases - protective and therapeutic role | breast cancer | HumanMolecular | blind women | Not specified | Protective role of melatonin in breast cancer: what we can learn from women with blindness.cited 2× |
| melatonin | Decreases - significant incidence decreases | breast cancer risk | HumanMolecular | totally blind women | Not specified | Protective role of melatonin in breast cancer: what we can learn from women with blindness.cited 2× |
| melatonin levels | No effect - absence of correlation | breast cancer occurrence | HumanMolecular | premenopausal women | Not specified | Protective role of melatonin in breast cancer: what we can learn from women with blindness.cited 2× |
| melatonin levels | Decreases - significantly decreased risk | breast cancer occurrence | HumanMolecular | postmenopausal women | Not specified | Protective role of melatonin in breast cancer: what we can learn from women with blindness.cited 2× |
| melatonin | No effect - will become one of the most common therapeutic drugs | breast cancer | Human | — | — | Molecular and cellular mechanisms of melatonin in breast cancer.cited 9× |
| melatonin | Decreases - inhibits the development of | breast cancer | Molecular | — | Not mentioned | Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms.cited 14× |
| melatonin | Decreases - inhibits | breast cancer cell growth | Human | — | Not specified | Melatonin, an inhibitory agent in breast cancer.cited 68× |
| melatonin | Decreases - is toxic to | breast cancer cell survival | Molecular | breast cancer cells | Not specified | Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology.cited 20× |
| Melatonin | Decreases - display anti-proliferative effects on | breast cancer growth and proliferation | Human | — | Not specified | Circadian Rhythm and Concentration of Melatonin in Breast Cancer Patients.cited 11× |
| Melatonin levels | No effect - correlate with | clinical and psychological symptoms of breast cancer | Human | — | Not specified | Circadian Rhythm and Concentration of Melatonin in Breast Cancer Patients.cited 11× |
| melatonin | No effect - important role | breast cancer prevention and adjuvant therapy | HumanMolecular | — | Not specified | The Role of Oxidative Stress Modulators in Breast Cancer.cited 73× |
| Melatonin | Decreases - inhibits | human breast cancer cells stimulated with estrogen | HumanMolecular | human MCF-7 cell line | Dose-dependent (specific amounts not provided). | Breast cancer cells: Modulation by melatonin and the ubiquitin-proteasome system--a review.cited 27× |
| Melatonin | Decreases - has been shown to inhibit | proliferation of estrogen receptor α (ERα)-positive human breast cancer cells | AnimalMolecular | in vitro | — | In vitro and in vivo antitumor activity of melatonin receptor agonists. |
| melatonin (MLT) | Decreases - significant | risk of breast cancer | Human | — | Not specified | Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action.cited 55× |
| low level of circulatory melatonin concentration | Increases - influences the development of | many cancers, including breast cancer | Molecular | — | — | Melatonin: A Potential Antineoplastic Agent in Breast Cancer. |
| low level of circulatory melatonin concentration | Increases - influences the development of | many cancers, including breast cancer | Molecular | — | — | Melatonin: A Potential Antineoplastic Agent in Breast Cancer. |