31
20
↑31
↓20
—0
Evidence suggests Melatonin mayincreaseApoptosis.
48 studies (51 claims)
Exact normalized-entity scope. Exact scope. Claims must match the selected normalized intervention and endpoint IDs; signal links are not expanded. Direction describes the stored endpoint phrase and is not a benefit/harm judgement.
42 of 54
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| Melatonin | Decreases - preventing | apoptosis | Human | — | Not specified | Melatonin in septic shock: some recent concepts.cited 64× |
| melatonin | Increases - promotes apoptosis | apoptosis | HumanMolecular | Ramos (Epstein-Barr virus-negative BL), SU-DHL-4 (diffuse large B cell lymphoma), DoHH2 (follicular B non-Hodgkin lymphoma) and JURKAT (acute T cell leukaemia) cell lines | Not specified | Melatonin inhibits cell proliferation and induces caspase activation and apoptosis in human malignant lymphoid cell lines. |
| melatonin | Increases - promotes | apoptosis | HumanMolecular | most tumor cells | Not specified | Melatonin, a natural programmed cell death inducer in cancer.cited 52× |
| melatonin | No effect - modulation | apoptosis | Human | experimental models of colitis | Not specified | Melatonin, autophagy and intestinal bowel disease.cited 15× |
| melatonin | Decreases - limited | apoptosis | Human | animal models of CKD | Not specified | Melatonin and renal protection: novel perspectives from animal experiments and human studies (review).cited 35× |
| melatonin | Increases - inducing | apoptosis | AnimalMolecular | ER-positive canine mammary tumors | — | Evaluation of melatonin treatment in primary culture of canine mammary tumors. |
| melatonin | Increases - induced | apoptosis | AnimalMolecular | canine mammary tumors | — | Evaluation of melatonin treatment in primary culture of canine mammary tumors. |
| melatonin | Decreases - decrease | apoptosis | Animal | — | Not specified | Protective actions of melatonin and growth hormone on the aged cardiovascular system.cited 22× |
| melatonin | Decreases - may be potential agents for counteracting | apoptosis | Animal | aging heart | Not specified | Protective actions of melatonin and growth hormone on the aged cardiovascular system.cited 22× |
| melatonin | Increases - promotion of | apoptosis | Human | — | Not specified | Melatonin as a treatment for gastrointestinal cancer: a review.cited 77× |
| melatonin | Increases - able to induce | apoptosis | Human | — | Not specified | Melatonin, an inhibitory agent in breast cancer.cited 68× |
| melatonin | Decreases - effectively reversed | apoptosis | AnimalMolecular | young male Sprague-Dawley rats | — | Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats. |
| melatonin | Decreases - exerted its effect | apoptosis | AnimalMolecular | HepG2 cells | — | Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats. |
| melatonin | Decreases - reduces | apoptosis | Human | critically ill patients | Not mentioned | Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.cited 159× |
| melatonin | Increases - stimulation | apoptosis | HumanMolecular | — | Not specified | Melatonin for the prevention and treatment of cancer. |
| melatonin (20 mg/kg body weight) | Decreases - reduced | apoptosis | Animal | mice | — | Melatonin protects against cisplatin-induced ovarian damage in mice via the MT1 receptor and antioxidant activity. |
| melatonin (MLT) | Increases - exhibits multi-targeted anticancer effects | apoptosis | HumanMolecular | numerous human malignancies | Not specified | Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer.cited 7× |
| melatonin | Increases - induced significant apoptosis | apoptosis | Molecular | TSCC cell line Cal27 | — | Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma. |
| melatonin | Increases - helpful in promoting | apoptosis | HumanMolecular | cancer-cell | Not specified | Mitochondrial functions and melatonin: a tour of the reproductive cancers.cited 39× |
| melatonin | Increases - has apoptosis induction characteristics through regulating signaling pathways | apoptosis | Human | — | Not specified | Potential use of melatonin in skin cancer treatment: A review of current biological evidence.cited 32× |
| melatonin | Increases - stimulation of | apoptosis | Human | — | Not specified | Melatonin is a potential inhibitor of ovarian cancer: molecular aspects.cited 26× |
| Melatonin | Increases - facilitate | apoptosis | Molecular | — | Not specified. | Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review.cited 94× |
| melatonin | Increases - induction of | apoptosis | Human | colorectal cancers | Not specified | Melatonin: An important anticancer agent in colorectal cancer.cited 24× |
| melatonin | Decreases - leads to inhibition | apoptosis | Human | PD | Not specified | Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms.cited 47× |
| Melatonin | Increases - has significant apoptotic effects | apoptosis | Molecular | various oncological cells | Not specified | Melatonin and its ubiquitous anticancer effects. |
| Melatonin | Increases - stimulation of apoptosis | apoptosis | Molecular | — | Not specified | Melatonin and its ubiquitous anticancer effects. |
| melatonin | Increases - favors in activating | apoptosis | Human | — | Not specified | Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action.cited 20× |
| melatonin | Increases - has been sparingly investigated to counteract | apoptosis | HumanMolecular | osteosarcoma cell lines | Not specified | Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma.cited 35× |
| melatonin | Increases - evoked induction of apoptosis | apoptosis | HumanMolecular | osteosarcoma models | Not specified | Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma.cited 35× |
| melatonin | Increases - causes them to more readily undergo | apoptosis | HumanMolecular | cancer cells | Not mentioned | Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis.cited 49× |
| melatonin | Increases - induction | apoptosis | Molecular | — | Not specified | Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.cited 117× |
| melatonin | Increases - induces | apoptosis | Molecular | — | — | Melatonin: A Potential Antineoplastic Agent in Breast Cancer. |
| melatonin | Increases - inducing apoptosis | apoptosis | Human | — | — | Melatonin and 5-fluorouracil combination chemotherapy: opportunities and efficacy in cancer therapy.cited 36× |
| melatonin | Decreases - upregulation of E26 oncogene homolog 1 (ETS1) contributed to the antiapoptotic effect | apoptosis | HumanMolecular | hyperoxia-exposed A549 cells | — | Melatonin Protects Against Hyperoxia-Induced Apoptosis in Alveolar Epithelial type II Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling Pathway. |
| melatonin | Decreases - inhibited | apoptosis | HumanMolecular | hyperoxia-exposed A549 cells | — | Melatonin Protects Against Hyperoxia-Induced Apoptosis in Alveolar Epithelial type II Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling Pathway. |
| Melatonin | Increases - promoting | apoptosis | Human | — | Not specified | Melatonin as a Promising Agent for Cancer Treatment: Insights into its Effects on the Wnt/beta-catenin Signaling Pathway.cited 3× |
| melatonin (MLT) | Increases - causing | apoptosis | Human | — | Not specified | Melatonin and cisplatin co-treatment against cancer: A mechanistic review of their synergistic effects and melatonin's protective actions.cited 2× |
| melatonin | Increases - induction of apoptosis | apoptosis | Human | — | Not specified | Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations.cited 7× |
| Melatonin | Increases - enhanced | apoptosis | HumanAnimalMolecular | cancer cells | — | Quantum mechanics insights into melatonin and analogs binding to melatonin MT |
| melatonin | Decreases - reduction of | apoptosis | Molecular | — | Not specified | Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review.cited 5× |
| melatonin | Increases - induce | apoptosis | HumanMolecular | — | Not specified | Melatonin for gastric cancer treatment: where do we stand? |
| melatonin | Decreases - demonstrated protective effects | apoptosis | Human | — | Not specified | Unveiling the Protective Roles of Melatonin on Glial Cells in the Battle Against Alzheimer's Disease-Insights from In Vivo and In Vitro Studies. |