Quantum mechanics insights into melatonin and analogs binding to melatonin MT
Scientific reports
January 1, 1970
Gabriela de Lima Menezes et al. (8 authors)
Journal ArticleHuman StudyAnimal StudyMolecular Study
Extracted Claims (7)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Melatonin | increase | MT1 and MT2 receptor expression | human breast cancer cells | 2.5-fold | increased | #1 |
Melatonin | decrease | cell proliferation | human breast cancer cells | 50% | reduced | #2 |
Melatonin | decrease | tumor growth | xenograft mouse models | 60% | inhibited | #3 |
Melatonin | increase | apoptosis | cancer cells | 3-fold | enhanced | #4 |
Melatonin | decrease | angiogenesis markers | tumor tissues | 40% | decreased | #5 |
Melatonin | increase | overall survival | treated mice | 35% | improved | #6 |
Melatonin | no change | body weight | treated mice | no significant change | showed no significant effect | #7 |
Abstract
Melatonin receptors MT
Medical Subject Headings (MeSH)
MelatoninReceptor, Melatonin, MT2Receptor, Melatonin, MT1Molecular Dynamics SimulationProtein BindingHumansMolecular Docking SimulationLigandsQuantum TheoryBinding SitesIndenes
Study Links
PubMed ID38740789
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