6
20
3
↑6
↓20
—3
Evidence suggests Magnesium maydecreaseStress.
26 studies (29 claims)
Moderate consensus
Typical effective dose 0.5 (0.5–0.5) %across 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| mild or moderate magnesium deficiency | Increases - contribute to | inflammatory stress | Human | — | Not specified | The Role of Dietary Magnesium in Cardiovascular Disease.cited 2× |
| mild or moderate magnesium deficiency | Increases - contribute to | oxidative stress | Human | — | Not specified | The Role of Dietary Magnesium in Cardiovascular Disease.cited 2× |
| dietary potassium magnesium sulphate (PMS) supplementation | Decreases - mitigates | transport stress | Animal | finishing pigs | 0.50% PMS added to the basal diet. | Preliminary Research on Dietary Supplementation of Potassium Magnesium Sulphate on Transport Stress in Finishing Pigs Prior to Slaughter. |
| vitamin D and magnesium supplementation | No effect - evaluate the effect | clinical symptoms and serum inflammatory and oxidative stress markers | Human | patients with COVID-19 | Vitamin D (50,000 IU capsules at specific intervals) and magnesium (300 mg/day). | The effect of vitamin D and magnesium supplementation on clinical symptoms and serum inflammatory and oxidative stress markers in patients with COVID-19: a structured summary of a study protocol for a randomized controlled trial.cited 3× |
| magnesium alone (Magnespasmyl [Mg]; daily dose 300 mg) | Decreases - substantially reduced | DASS-42 stress subscale score | Human | healthy adults with Depression Anxiety Stress Scales (DASS-42) stress subscale score >18 and serum magnesium concentration 0.45 mmol/L-0.85 mmol/L | 30 mg vitamin B6 daily (combined with 300 mg magnesium). | Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.cited 27× |
| magnesium-vitamin B6 combination (Magne B6 [Mg-vitamin B6]; daily dose 300 mg and 30 mg, respectively) | Decreases - substantially reduced | DASS-42 stress subscale score | Human | healthy adults with Depression Anxiety Stress Scales (DASS-42) stress subscale score >18 and serum magnesium concentration 0.45 mmol/L-0.85 mmol/L | 30 mg vitamin B6 daily (combined with 300 mg magnesium). | Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.cited 27× |
| magnesium-vitamin B6 combination (Magne B6 [Mg-vitamin B6]; daily dose 300 mg and 30 mg, respectively) | Decreases - had a 24% greater improvement | DASS-42 stress subscale score | Human | adults with severe/extremely severe stress (DASS-42 stress subscale score ≥25) | 30 mg vitamin B6 daily (combined with 300 mg magnesium). | Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.cited 27× |
| magnesium alone | Decreases - stress reduction was achieved | stress | Human | individuals with low magnesemia and severe/extremely severe stress but who were otherwise healthy | — | Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.cited 22× |
| magnesium combined with vitamin B6 | Decreases - greater stress reduction was achieved | stress | Human | individuals with low magnesemia and severe/extremely severe stress but who were otherwise healthy | — | Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.cited 22× |
| Magnesium-L-threonate treatment | Decreases - reduced | oxidative stress | HumanAnimal | a double-transgenic line of Alzheimer's disease model mice expressing the amyloid-β precursor protein and mutant human presenilin 1 (APP/PS1) | Not specified in the abstract. | Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis.cited 9× |
| Magnesium dititanate (MgTi2O5) nanoparticles | Decreases - protected against | oxidative stress-induced cell damage | HumanMolecular | human endothelial cells | — | Magnesium dititanate (MgTi |
| magnesium supplementation | Decreases - significantly reduced | stress | Human | severely stressed subjects with low magnesemia | 30 mg vitamin B6 daily (combined with 300 mg magnesium). | Impact of magnesium supplementation, in combination with vitamin B6, on stress and magnesium status: secondary data from a randomized controlled trial.cited 9× |
| Magnesium and vitamin B6 | No effect - did not affect | stress | Human | women suffering from dysmenorrhea when combined or used in isolation | Not specified | The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women: a systematic review.cited 24× |
| magnesium | Decreases - plays an inhibitory key role in the regulation and neurotransmission | normal stress response | Human | — | — | Magnesium Status and Stress: The Vicious Circle Concept Revisited.cited 63× |
| magnesium deficiency | Increases - could enhance | body's susceptibility to stress | Human | — | — | Magnesium Status and Stress: The Vicious Circle Concept Revisited.cited 63× |
| magnesium | Decreases - significant improvement | oxidative stress | Animal | menopausal ovariectomized rats | Not specified. | Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. |
| magnesium | Decreases - antioxidant potential | oxidative stress | Human | children | Not available | Dietary Strategies in the Prevention and Treatment of Hypertension in Children and Adolescents: A Narrative Review.cited 3× |
| Magnesium (Mg) | Decreases - reduces | oxidative stress (OS) | Human | human participants | Not mentioned. | Antioxidant/anti-inflammatory effect of Mgcited 12× |
| magnesium | Decreases - indirectly by reducing | oxidative stress and chronic low-grade inflammation | Molecular | — | Not provided | Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review.cited 17× |
| magnesium | Decreases - useful to alleviate | phosphate-induced calcification stress | HumanMolecular | — | — | Magnesium in Hemodialysis Patients: A New Understanding of the Old Problem.cited 4× |
| Vitamin E supplementation or vitamin E in combination with omega-3 or magnesium | No effect - No significant effect was found | other biomarkers of inflammation or oxidative stress | Human | patients with PCOS | Not specified | A meta-analysis of effects of vitamin E supplementation alone and in combination with omega-3 or magnesium on polycystic ovary syndrome.cited 10× |
| trace elements and magnesium (Mg) | Increases - improve | glucose metabolism, markers of inflammation, and oxidative stress | Human | — | Not specified | Magnesium and trace element intake after a lifestyle intervention.cited 5× |
| magnesium administration | Decreases - target the acute injury phase | oxidative stress associated with hypoxic-ischemic encephalopathy | Human | — | Not specified | Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia.cited 63× |
| maintaining an adequate dietary intake of vitamin D, iron, fibre, zinc and magnesium | Decreases - may have a beneficial effect on reducing | oxidative stress | Human | — | Not specified | Modulation of the Gut Microbiota by Nutrition and Its Relationship to Epigenetics.cited 17× |
| magnesium-zinc-calcium-vitamin D co-supplementation | Decreases - may reduce | biomarkers of inflammation and oxidative stress | Human | women with GDM | Not specified | The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes.cited 90× |
| magnesium-zinc-calcium-vitamin D co-supplementation | No effect - failed to find any significant effect | other biomarkers of oxidative stress | Human | women with PCOS | 400 mg calcium (plus 100 mg magnesium, 4 mg zinc, and 200 IU vitamin D) twice daily | Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.cited 38× |
| Magnesium deficiency | Increases - contributes to the development | oxidative stress | Human | obese individuals | Not specified | Role of Magnesium in Oxidative Stress in Individuals with Obesity.cited 82× |
| Magnesium-L-threonate (MgT) | Decreases - prevented | Aβ25-35-triggered oxidative stress damage | AnimalMolecular | Aβ25-35-induced HT22 cells | Not specified for HT22 cells; oral administration daily for mice (exact dosage not mentioned). | Magnesium-L-threonate exhibited a neuroprotective effect against oxidative stress damage in HT22 cells and Alzheimer's disease mouse model.cited 24× |
| Magnesium-L-threonate (MgT) | Decreases - decline | oxidative stress | Animal | rats | 50 mg/kg, 100 mg/kg, and 150 mg/kg | Neurobehavioral and biochemical effects of magnesium chloride (MgCl2), magnesium sulphate (MgSO4) and magnesium-L-threonate (MgT) supplementation in rats: A dose dependent comparative study.cited 8× |