Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.
Stress and health : journal of the International Society for the Investigation of Stress
December 1, 2021
Lionel Noah et al. (6 authors)
Journal ArticleRandomized Controlled TrialHuman StudyClinical
Extracted Claims (3)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
magnesium combined with vitamin B6 | decrease | stress | individuals with low magnesemia and severe/extremely severe stress but who were otherwise healthy | - | greater stress reduction was achieved | #1 |
magnesium alone | decrease | stress | individuals with low magnesemia and severe/extremely severe stress but who were otherwise healthy | - | stress reduction was achieved | #2 |
magnesium, with and without vitamin B6 | neutral | depression, anxiety, and QoL | Adults with Depression Anxiety Stress Scales (DASS-42) stress subscale score >18 | - | effect | #3 |
Abstract
Magnesium status and vitamin B6 intake have been linked to mental health and/or quality of life (QoL). In an 8-week Phase IV randomised controlled study in individuals with low magnesemia and severe/extremely severe stress but who were otherwise healthy, greater stress reduction was achieved with magnesium combined with vitamin B6 than with magnesium alone. We present a previously unreported secondary analysis of the effect of magnesium, with and without vitamin B6, on depression, anxiety, and QoL. Adults with Depression Anxiety Stress Scales (DASS-42) stress subscale score >18 were randomised 1:1 to magnesium + vitamin B6 combination (Magne B6
Medical Subject Headings (MeSH)
AdultDietary SupplementsHumansMagnesiumMental HealthQuality of LifeVitamin B 6
Study Links
PubMed ID33864354
Citation Metrics
Total Citations22
Citations/Year5.5
Relative Citation Ratio2.58
NIH Percentile81.6%
Research Impact Scores
APT Score0.75
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