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Evidence shows mixed or conflicting results for Creatine on Time to fatigue.
17 studies (23 claims)
Conflicting evidence
Typical effective dose 18000 (17000–19000) mgacross 2 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| Creatine monohydrate supplementation coupled with RT (Cr + RT) | Decreases - may address | fatigue barrier | Human | CSPC survivors | Not specified (only mentions "an established creatine supplementation protocol"). | Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression (CREATINE-52): a protocol for a double-blind randomized controlled trial.cited 1× |
| low-dose creatine supplementation | Increases - more resistant to fatigue | fatigue resistance during set 2 | Human | creatine-supplemented volunteers | 0.03 g/kg/day (≈2.3 g/day). | Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain.cited 27× |
| low-dose creatine supplementation | Increases - more resistant to fatigue | fatigue resistance during set 3 | Human | creatine-supplemented volunteers | 0.03 g/kg/day (≈2.3 g/day). | Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain.cited 27× |
| low-dose creatine supplementation | Increases - more resistant to fatigue | fatigue resistance during set 4 | Human | creatine-supplemented volunteers | 0.03 g/kg/day (≈2.3 g/day). | Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain.cited 27× |
| low-dose creatine supplementation | Increases - more resistant to fatigue | fatigue resistance during set 5 | Human | creatine-supplemented volunteers | 0.03 g/kg/day (≈2.3 g/day). | Low-dose creatine supplementation enhances fatigue resistance in the absence of weight gain.cited 27× |
| creatine monohydrate | Decreases - may also reduce | fatigue | Human | — | Not available | Assessment and management of fatigue in neuromuscular disease.cited 34× |
| creatine supplementation therapy | Increases - coincided with improvements in | fatigue and exercise intolerance | Human | 29-year-old female with PGM1-CDG | Not specified | Outcome of creatine supplementation therapy in phosphoglucomutase-1 deficiency associated congenital disorders of glycosylation: Novel insights. |
| Creatine supplementation | Increases - beneficial effects | encephalopathy and fatigue | Human | — | Not mentioned | Creatine Supplementation to Improve Sarcopenia in Chronic Liver Disease: Facts and Perspectives.cited 13× |
| Creatine supplementation | Decreases - improved | fatigue | Human | ME/CFS patients | 16 g creatine monohydrate daily. | Six-Week Supplementation with Creatine in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Magnetic Resonance Spectroscopy Feasibility Study at 3 Tesla. |
| Creatine supplementation | Decreases - decreased | fatigue | Human | participants with ME/CFS | 16 g creatine monohydrate daily. | Six-Week Supplementation with Creatine in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Magnetic Resonance Spectroscopy Feasibility Study at 3 Tesla. |
| creatine supplementation | No effect - was not found effective | fatigue | Human | patients with Pediatric Rheumatic Conditions (PRCs) | Not specified | Reducing fatigue in pediatric rheumatic conditions: a systematic review.cited 5× |
| creatine supplementation | No effect - no significant changing | fatigue index | Human | strength-trained men | 20g Creatine + 10g maltodextrin daily. | Short term creatine loading improves strength endurance even without changing maximal strength, RPE, fatigue index, blood lactate, and mode state. |
| creatine supplementation | No effect - No significant differences were found | Fatigue Index | Human | Fourteen males | Not specified | The effects of creatine supplementation on thermoregulation and isokinetic muscular performance following acute (3-day) supplementation.cited 8× |
| creatine supplementation | Increases - benefits | fatigue resistance | Human | young adults | 20 g/day for 5 days or 2 g/day for 30 days | Use of creatine in the elderly and evidence for effects on cognitive function in young and old.cited 68× |
| concurrent creatine supplementation and resistance training | Increases - enhance | fatigue resistance | Human | older adults | 20 g/day for 5 days or 2 g/day for 30 days | Use of creatine in the elderly and evidence for effects on cognitive function in young and old.cited 68× |
| short-term high-dose creatine supplementation, independent of exercise training | Increases - enhances | fatigue resistance | Human | older adults | 20 g/day for 5 days or 2 g/day for 30 days | Use of creatine in the elderly and evidence for effects on cognitive function in young and old.cited 68× |
| Creatine | Decreases - reduced fatigue at follow-up | fatigue | Human | children at onset of injury | Not specified | Fatigue After Traumatic Brain Injury: A Systematic Review.cited 20× |
| creatine | No effect - no statistically significant changes | fatigue | Human | patients with juvenile dermatomyositis (JDM) | Not specified in the abstract. | The Effect of Creatine Supplementation on Muscle Function in Childhood Myositis: A Randomized, Double-blind, Placebo-controlled Feasibility Study.cited 10× |
| creatine | Decreases - delay the onset of fatigue | fatigue | Human | — | Not available | Effects of amino acid derivatives on physical, mental, and physiological activities.cited 19× |
| creatine (20 g) | Decreases - the number of repetitions performed decreasing similarly for creatine and placebo | leg press and chest press repetitions to muscle fatigue (3 sets at 70% 1-repetition maximum; 1 minute rest between sets) | Human | healthy males (N = 9, 54.8 ± 4.3 years; 92.9 ± 11.5 kg; 179.2 ± 11.1 cm) | 20 g maltodextrin (single dose). | Effect of Preexercise Creatine Ingestion on Muscle Performance in Healthy Aging Males.cited 11× |
| Beta-alanine and beta alanine plus creatine supplementations | Decreases - have strong performance enhancing effect by delaying | fatigue Index | Human | — | 1.6 g beta-alanine twice daily for 22 days, then four times daily for 6 days (combined with maltodextrose). | The effects of beta alanine plus creatine administration on performance during repeated bouts of supramaximal exercise in sedentary men.cited 5× |
| creatine monohydrate supplementation | Decreases - significant benefits | muscular fatigue symptoms | Human | 39-year-old female with Ehlers-Danlos syndrome | Not specified | Creatine Monohydrate as an Effective Supplement for Muscular Fatigue in an Ehlers-Danlos Patient. |
| creatine administration | No effect - results were conflicting | long-term memory, spatial memory, memory scanning, attention, executive function, response inhibition, word fluency, reaction time and mental fatigue | Human | — | Not specified | Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials.cited 68× |