Creatine Supplementation to Improve Sarcopenia in Chronic Liver Disease: Facts and Perspectives.
Study Goal
The researchers aimed to summarize the current evidence for creatine supplementation in advanced chronic liver disease, particularly in sarcopenic cirrhotic patients, and its potential benefits on complications like encephalopathy and fatigue.
Results Summary
The abstract suggests creatine supplementation may have beneficial effects on sarcopenia, fatty liver, encephalopathy, and fatigue in advanced chronic liver disease, though human studies are lacking and evidence is primarily from animal models. Further research is needed to confirm these potential benefits.
Population
Sarcopenic cirrhotic patients and animal models of non-alcoholic fatty liver disease.
Effective Dosage
Not mentioned
Duration
Not mentioned
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Creatine supplementation | increase | performance, strength, and muscular mass | athletes | - | has been one of the most studied and useful ergogenic nutritional support | #1 |
creatine | increase | several human disease conditions | - | - | has shown beneficial effects | #2 |
creatine supplementation | increase | chronic liver disease | - | - | potential efficacy | #3 |
creatine supplementation | increase | fatty liver | animal models of non-alcoholic fatty liver disease | - | bringing beneficial effects | #4 |
Creatine supplementation | increase | encephalopathy and fatigue | - | - | beneficial effects | #5 |
Creatine supplementation | increase | sarcopenia | the elderly with and without resistance training | - | has demonstrated effects | #6 |
Creatine supplementation | increase | this condition | patients with advanced chronic liver disease | - | potential role in improving | #7 |
Creatine supplementation | increase | chronic liver disease and its complications | - | - | could address several critical points | #8 |
Creatine supplementation has been one of the most studied and useful ergogenic nutritional support for athletes to improve performance, strength, and muscular mass. Over time creatine has shown beneficial effects in several human disease conditions. This review aims to summarise the current evidence for creatine supplementation in advanced chronic liver disease and its complications, primarily in sarcopenic cirrhotic patients, because this condition is known to be associated with poor prognosis and outcomes. Although creatine supplementation in chronic liver disease seems to be barely investigated and not studied in human patients, its potential efficacy on chronic liver disease is indirectly highlighted in animal models of non-alcoholic fatty liver disease, bringing beneficial effects in the fatty liver. Similarly, encephalopathy and fatigue seem to have beneficial effects. Creatine supplementation has demonstrated effects in sarcopenia in the elderly with and without resistance training suggesting a potential role in improving this condition in patients with advanced chronic liver disease. Creatine supplementation could address several critical points of chronic liver disease and its complications. Further studies are needed to support the clinical burden of this hypothesis.