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Evidence suggests Creatine mayincreaseCognitive function.
8 studies (11 claims)
Moderate consensus
Typical effective dose 20000 (20000–20000) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| creatine and CoQ10 combination therapy | Increases - could delay the decline | cognitive function | Human | PD-MCI patients | CoQ10 100 mg three times daily (t.i.d.) and creatine monohydrate 5 g twice daily (b.i.d.). | The effect of creatine and coenzyme q10 combination therapy on mild cognitive impairment in Parkinson's disease.cited 42× |
| creatine nitrate and caffeine that were co-ingested | Increases - significantly enhanced | cognitive function | Human | resistance-trained male athletes | 400 mg/day | The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial.cited 6× |
| formulated Dodecyl creatine ester (DCE) | No effect - modulates the expression of neuronal markers related to cognitive function | expression of neuronal markers related to cognitive function | HumanAnimal | various animal models, including wild-type non-human primates and creatine transporter deficient mice | Not specified | Dodecyl creatine ester, a promising treatment to deliver creatine to neurons, achieves pharmacology efficacy in creatine transporter deficiency. |
| creatine supplementation | No effect - a cause-and-effect relationship has not been established | improvement in cognitive function in one or more of its domains | Human | — | 2.2-20 g/day, with acute effects observed at 20 g/day for 5-7 days and continuous consumption at 5 g/day for 6 weeks after a 5-day loading phase. | Creatine and improvement in cognitive function: Evaluation of a health claim pursuant to article 13(5) of regulation (EC) No 1924/2006.cited 1× |
| creatine | Increases - improves | cognitive function | Human | normal and elderly people | Not specified | Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy.cited 53× |
| creatine (supplementation or habitual diet) | Increases - provides a ray of 'hope' for improving | some aspects of cognitive function | Human | — | Not specified | Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults?cited 3× |
| creatine monohydrate supplementation | Increases - was more beneficial in | cognitive function | Human | individuals with diseases | Not specified | The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.cited 7× |
| creatine monohydrate supplementation | Increases - was more beneficial in | cognitive function | Human | those aged 18-60 years | Not specified | The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.cited 7× |
| creatine monohydrate supplementation | Increases - was more beneficial in | cognitive function | Human | females | Not specified | The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.cited 7× |
| creatine monohydrate supplementation | No effect - No significant differences were found between | cognitive function | Human | — | Not specified | The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.cited 7× |
| creatine monohydrate supplementation | No effect - no significant improvements were found on | overall cognitive function | Human | adults | Not specified | The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.cited 7× |