7
↑7
↓0
—0
Evidence suggests Caffeine mayincreaseToxicity.
3 studies (7 claims)
Emerging evidence
Typical effective dose 6030 (3045–9015) mgacross 2 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| a higher caffeine dosing regimen | Increases - demonstrated significant toxicity | toxicity | Animal | lambs | 1 g IV caffeine citrate pre-delivery, 20 mg/kg IV post-resuscitation, and 10 mg/(kg·d) IV for 2 days; an additional cohort received 60 mg/kg followed by 30 mg/(kg·d). | Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.cited 2× |
| caffeine-related drug interactions with d-amphetamine | Increases - similar mechanisms are implicated | drug-related toxicity | Animal | — | Not specified | Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.cited 36× |
| caffeine-related drug interactions with ephedrine | Increases - similar mechanisms are implicated | drug-related toxicity | Animal | — | Not specified | Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.cited 36× |
| caffeine-related drug interactions with cocaine | Increases - similar mechanisms are implicated | drug-related toxicity | Animal | — | Not specified | Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.cited 36× |
| Co-administration of caffeine | Increases - profoundly enhances | the acute toxicity of MDMA | Animal | rats | Not specified | Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.cited 36× |
| caffeine | Increases - increases | the toxicity of psychostimulants | Animal | — | Not specified | Caffeine provokes adverse interactions with 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and related psychostimulants: mechanisms and mediators.cited 36× |
| caffeine | Increases - is profoundly toxic and can result in death | toxicity | Human | — | Approximately 12 g of pure caffeine anhydrous (single ingestion). | Fatal caffeine overdose: a case report and review of literature.cited 51× |