Fatal caffeine overdose: a case report and review of literature.
Study Goal
The researchers aimed to highlight the toxicity risks of high-dose caffeine anhydrous consumption and advocate for better labeling and forensic toxicology practices.
Results Summary
The study reported a fatal caffeine overdose in a 39-year-old man who ingested approximately 12 g of pure caffeine anhydrous, with autopsy blood levels at 350 mg/L. The authors recommend mandated toxicity warnings and inclusion of caffeine in forensic toxicology panels.
Population
A 39-year-old man (case study).
Effective Dosage
Approximately 12 g of pure caffeine anhydrous (single ingestion).
Duration
Not specified (acute overdose).
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
caffeine | increase | toxicity | - | - | is profoundly toxic and can result in death | #1 |
caffeine anhydrous | increase | mortality | a 39-year-old man | approximately 12 g | resulting in fatal overdose | #2 |
caffeine anhydrous | increase | blood caffeine levels | a 39-year-old man | 350 mg/L | resulting in blood caffeine levels | #3 |
Caffeine is a central nervous system stimulant that is consumed by large numbers of people on a routine basis, usually in the form of coffee or tea. However, if consumed in high doses, this xanthine alkaloid is profoundly toxic and can result in death. Increasingly being sold as a dietary supplement, many people, particularly those in the health and fitness community, where it is touted as a fitness and muscle building aid, are consuming caffeine anhydrous on a daily basis. We report a case of fatal caffeine overdose in a 39-year-old man resulting from the self-administered ingestion of approximately 12 g of pure caffeine anhydrous. Autopsy blood caffeine levels were 350 mg/L. We recommend mandated labeling of pure caffeine anhydrous, highlighting the toxicity risk of ingesting this chemical; and we recommend ensuring that caffeine levels are included in the comprehensive forensic toxicology panel performed on all cases.