12
5
1
↑12
↓5
—1
Evidence suggests Alcohol mayincreaseStress levels.
17 studies (18 claims)
Moderate consensus
Typical effective dose 100 (100–100) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| low doses of alcohol | Increases - exacerbated | oxidative stress and hepatopathogenesis induced by HCV | Human | — | — | Oxidative stress, endogenous antioxidants, alcohol, and hepatitis C: pathogenic interactions and therapeutic considerations.cited 49× |
| alcohol | Increases - capable of generating | oxidative stress | Molecular | brain | Not available | Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis.cited 181× |
| alcohol cessation | Decreases - counteract | oxidative/nitroxidative stress | Human | patients with multiple sclerosis | Not specified | Oxidative/Nitroxidative Stress and Multiple Sclerosis.cited 48× |
| alcohol-free wine | No effect - could be an excellent source of antioxidants to protect | oxidative stress | Human | people suffering from oxidative stress (cancer, diabetes, alzheimer, etc.) | 300 mL of alcohol-free wine. | Intake of alcohol-free red wine modulates antioxidant enzyme activities in a human intervention study.cited 34× |
| prenatal alcohol exposure (PAE) | Increases - increases | levels of stress hormones | Human | — | — | Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol.cited 32× |
| alcohol co-treatment | No effect - did not reverse | stress induced decreases in NMDA receptors in the HIP | Animal | WKY rats and WIS rats | Not specified | N-methyl-d-aspartic acid receptors are altered by stress and alcohol in Wistar-Kyoto rat brain.cited 21× |
| Perillyl alcohol | Decreases - significantly reduced | oxidative-nitritive stress | Animal | Rats that received streptozotocin infusion | 25, 50, and 100 mg/kg administered orally (p.o.) | Neuroprotective effect of Perillyl alcohol in sporadic Alzheimer's disease in rats. |
| Alcohol abuse and adherence to atherogenic diet (AD) | Decreases - reduced antioxidative stress | antioxidative stress | Animal | mice with hyperlipidemia | — | Alcohol Consumption in Combination with an Atherogenic Diet Increased Indices of Atherosclerosis in Apolipoprotein E/Low-Density Lipoprotein Receptor Double-Knockout Mice. |
| Alcohol abuse and adherence to atherogenic diet (AD) | Increases - may promote the shift of aortic oxidative stress and antioxidative stress balance toward oxidative stress predominance | aortic oxidative stress and antioxidative stress balance | Animal | mice with hyperlipidemia | — | Alcohol Consumption in Combination with an Atherogenic Diet Increased Indices of Atherosclerosis in Apolipoprotein E/Low-Density Lipoprotein Receptor Double-Knockout Mice. |
| cinnamyl alcohol dehydrogenase CcCAD10 | Increases - was identified to be involved in | melatonin treatment and salt stress | Animal | pigeon pea | Not specified | Melatonin enhances salt tolerance by promoting CcCAD10-mediated lignin biosynthesis in pigeon pea. |
| concomitant use of a high-fat diet and alcohol | Increases - provoked | hepatic endoplasmic reticulum stress | HumanAnimal | rat model | 20% fat diet + 10% alcohol (half-dose) and 40% fat diet + 20% alcohol (double-dose). | Animal Evidence for Synergistic Induction of Hepatic Injury by Dietary Fat and Alcohol Consumption and Its Potential Mechanisms.cited 2× |
| patchouli alcohol (PA) | Decreases - suppressed | endoplasmic reticulum stress and apoptosis | AnimalMolecular | in vitro | — | Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury.cited 12× |
| Patchouli alcohol (PA) | Decreases - inhibited | hepatic endoplasmic reticulum (ER) stress | Animal | MASH rats | — | Patchouli alcohol alleviates metabolic dysfunction-associated steatohepatitis via inhibiting mitochondria-associated endoplasmic reticulum membrane disruption-induced hepatic steatosis and inflammation in rats.cited 4× |
| chronic alcohol administration | Increases - caused a significant increase | levels of ER-stress-associated proteins XBP1, GRP78, and CHOP | Animal | rat gastric tissues | — | Acetyl-L-carnitine attenuates chronic ethanol-induced oxidative stress, ER stress and apoptosis in rat gastric tissue. |
| chronic alcohol administration | Increases - caused a significant increase | TOS levels, an indicator of oxidative stress | Animal | rat gastric tissues | — | Acetyl-L-carnitine attenuates chronic ethanol-induced oxidative stress, ER stress and apoptosis in rat gastric tissue. |