Patchouli Alcohol Improves the Integrity of the Blood-Spinal Cord Barrier by Inhibiting Endoplasmic Reticulum Stress Through the Akt/CHOP/Caspase-3 Pathway Following Spinal Cord Injury.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
patchouli alcohol (PA) | decrease | spinal cord injury (SCI) | - | - | exerts protective effects | #1 |
patchouli alcohol (PA) | decrease | hyperpermeability of the BSCB | - | - | significantly prevented | #2 |
patchouli alcohol (PA) | decrease | tight junctions (TJs) and endothelial cells | - | - | reducing the loss | #3 |
patchouli alcohol (PA) | decrease | endoplasmic reticulum stress and apoptosis | in vitro | - | suppressed | #4 |
patchouli alcohol (PA) | increase | neurological deficits | rat model of SCI | - | effectively improved | #5 |
patchouli alcohol (PA) | neutral | - | - | - | exerts neuroprotective effects | #6 |
patchouli alcohol (PA) | increase | BSCB integrity | - | - | maintaining | #7 |
Spinal cord injury (SCI) is a destructive and complex disorder of the central nervous system (CNS) for which there is no clinical treatment. Blood-spinal cord barrier (BSCB) rupture is a critical event in SCI that aggravates nerve injury. Therefore, maintaining the integrity of the BSCB may be a potential method to treat SCI. Here, we showed that patchouli alcohol (PA) exerts protective effects against SCI. We discovered that PA significantly prevented hyperpermeability of the BSCB by reducing the loss of tight junctions (TJs) and endothelial cells. PA also suppressed endoplasmic reticulum stress and apoptosis in vitro. Furthermore, in a rat model of SCI, PA effectively improved neurological deficits. Overall, these results prove that PA exerts neuroprotective effects by maintaining BSCB integrity and thus be a promising candidate for SCI treatment.