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Evidence suggests Alcohol mayincreaseLiver injury.
10 studies (11 claims)
Moderate consensus
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| concomitant dietary fat intake and alcohol consumption | Increases - lead to | liver injury | HumanAnimal | — | 20% fat diet + 10% alcohol (half-dose) and 40% fat diet + 20% alcohol (double-dose). | Animal Evidence for Synergistic Induction of Hepatic Injury by Dietary Fat and Alcohol Consumption and Its Potential Mechanisms.cited 2× |
| high-fat/-calorie diet together with alcohol intake | Increases - deteriorates | steatotic liver injury | HumanAnimal | — | 20% fat diet + 10% alcohol (half-dose) and 40% fat diet + 20% alcohol (double-dose). | Animal Evidence for Synergistic Induction of Hepatic Injury by Dietary Fat and Alcohol Consumption and Its Potential Mechanisms.cited 2× |
| alcohol plus additional risk factors | Increases - exacerbation | liver injury | HumanAnimal | — | Not specified | Alcohol Plus Additional Risk Factors: Rodent Model of Liver Injury. |
| Alcohol | Increases - is associated with | spectrum of liver injury | Human | — | Not mentioned | Diagnosis of alcoholic liver disease.cited 112× |
| Long-term excessive alcohol feeding | Increases - caused | fatty liver and liver injury | AnimalMolecular | rats | — | Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver. |
| Alcohol intake | Increases - caused | liver injury | AnimalMolecular | mice fed a Lieber-DeCarli regular liquid alcohol diet | Not specified | Effects of Roasted Schisandra Chinensis (Turcz.) Baill and Lycium Chinense Mill. and Their Combinational Extracts on Antioxidant and Anti-Inflammatory Activities in RAW 264.7 Cells and in Alcohol-Induced Liver Damage Mice Model.cited 1× |
| Replacement of corn oil with medium chain triacylglycerols (MCT) in the diets of alcohol-fed rats | Decreases - has been shown to protect against | steatosis and alcoholic liver injury | Animal | alcohol-fed rats | Diets contained 10%, 35%, or 70% total energy as corn oil or a 70% fat diet with MCT-enriched saturated fat (18:82 beef tallow:MCT oil) at 20% to 65% replacement. | Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease.cited 47× |
| heavy alcohol consumption | Increases - predicted changes in | liver injury | Human | — | Not specified | Effects of Sex, Drinking History, and Omega-3 and Omega-6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol-Dependent Patients.cited 31× |
| alcohol administration (8 to 10 mL/kg/d) for 16 weeks | Increases - induced | liver injury | Animal | Sprague-Dawley rats | Low-dose (100 mg/kg/d), high-dose (200 mg/kg/d), and AKO control (200 mg/kg/d). | Antarctic krill oil ameliorates liver injury in rats exposed to alcohol by regulating bile acids metabolism and gut microbiota.cited 12× |
| higher alcohol intake (> 14 units per week) | Increases - increase the risk of | cellular liver injury | Human | long-term childhood cancer survivors | Not specified | Hepatic late adverse effects after antineoplastic treatment for childhood cancer.cited 25× |
| Patchouli alcohol (PA) | Decreases - was found to reduce | alcohol-induced acute liver injury (ALI) | Animal | male Wistar rats | — | Patchouli alcohol ameliorates acute liver injury via inhibiting oxidative stress and gut-origin LPS leakage in rats.cited 22× |