Alcohol Plus Additional Risk Factors: Rodent Model of Liver Injury.
Study Goal
The researchers aimed to explore the synergistic effects of alcohol and a high-fat diet (HFD) in exacerbating liver injury, using rodent models to simulate human alcohol-associated liver disease (ALD).
Results Summary
The study found that a high-fat diet, when combined with alcohol consumption, increases susceptibility to liver injury, contributing to the progression of ALD. The rodent models demonstrated synergistic effects between alcohol and HFD, highlighting potential mechanisms for liver damage.
Population
Rodent models (not human subjects).
Effective Dosage
Not specified
Duration
Not specified
Interactions
Alcohol (synergistic effect with HFD)
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
chronic excessive alcohol consumption | increase | alcohol-associated liver disease (ALD) | - | - | primarily caused | #1 |
aldehyde dehydrogenase 2 (ALDH2) deficiency | increase | alcohol-associated liver disease (ALD) | - | - | increase susceptibility | #2 |
smoking | increase | alcohol-associated liver disease (ALD) | - | - | increase susceptibility | #3 |
medication administration | increase | alcohol-associated liver disease (ALD) | - | - | increase susceptibility | #4 |
high-fat diet (HFD) | increase | alcohol-associated liver disease (ALD) | - | - | increase susceptibility | #5 |
hepatitis virus infection | increase | alcohol-associated liver disease (ALD) | - | - | increase susceptibility | #6 |
disruption of circadian rhythms | increase | alcohol-associated liver disease (ALD) | - | - | increase susceptibility | #7 |
alcohol plus additional risk factors | increase | liver injury | - | - | exacerbation | #8 |
rodent models of EtOH + "X" | increase | liver injury | rodent models | - | simulate the synergistic effects | #9 |
Alcohol-associated liver disease (ALD), primarily caused by chronic excessive alcohol consumption, is a leading cause of chronic liver disease worldwide. ALD includes alcohol-associated steatotic liver, alcohol-associated hepatitis (AH), fibrosis, cirrhosis, and can even progress to hepatocellular carcinoma (HCC). Existing research indicates that the risk factors of ALD are quite numerous. In addition to drinking patterns, factors such as aldehyde dehydrogenase 2 (ALDH2) deficiency, smoking, medication administration, high-fat diet (HFD), hepatitis virus infection, and disruption of circadian rhythms can also increase susceptibility to ALD. However, there is limited understanding regarding the exacerbation of liver injury by alcohol plus additional risk factors. This review presents rodent models of EtOH + "X," which simulate the synergistic effects of alcohol and additional risk factors in causing liver injury. These models offer a further exploration of the interactions between alcohol and additional risk factors, advancing the simulation of human ALD and providing a more reliable platform for studying disease mechanisms and exploring therapeutic interventions. We summarize the modeling methods, relevant indicators of liver injury, and focus on the targets of the synergistic effects as well as the associated mechanisms.