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Evidence suggests Alcohol maydecreaseCNS depression.
5 studies (4 claims)
Emerging evidence
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| alcohol-soluble extracts and lignans from S. chinensis | Decreases - could significantly ameliorate | depression-like behaviors | Animal | animal models | 50, 200, and 800 mg/kg (i.g.) | The physicochemical characteristics and antidepressant-like effects of a polysaccharide-rich fraction from Schisandra chinensis (Turcz.) Baill in behavioral despair mice and olfactory bulbectomy-induced depression-like mice.cited 11× |
| Moderate alcohol intake within the range of 5 to 15 g/day | Decreases - significantly associated with lower risk | incident depression | Human | 5,505 high-risk men and women (55 to 80 y) of the PREDIMED Trial initially free of depression or a history of depression, and without any history of alcohol-related problems | 5-15 g/day of alcohol (approximately 2-7 drinks/week of wine). | Alcohol intake, wine consumption and the development of depression: the PREDIMED study.cited 81× |
| reduction of recreational substances such as nicotine, drugs, and alcohol | No effect - are modifiers of | depression | Human | — | Not specified | Lifestyle medicine for depression.cited 245× |
| Patchouli alcohol (PA) | Decreases - anti-depressant | depression | Human | — | — | Potential benefits of patchouli alcohol in prevention of human diseases: A mechanistic review.cited 32× |
| Patchouli alcohol (PA) | Decreases - exerted antidepressant-like effect | depression-like symptoms | Animal | CUMS rats | — | Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway.cited 34× |