Western Diet
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Evidence suggests Western Diet maydecreaseBody weight.

9 studies (10 claims)

Emerging evidence

Typical effective dose 16.25 (9.38–23.13) mgacross 2 dosed studies

Study Claims

10 of 10

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
acarbose	Decreases - decreases	body weight	Animal	WD-fed 3xTg mice	Not specified	Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease.cited 1×
acarbose	Decreases - decreases	body weight	Animal	WD-fed 3xTg mice	Not specified	Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease.cited 3×
western diet feeding	Increases - increased	body weight	Animal	C57BL/6J mice	Not specified	Effect of chronic restraint stress and western-diet feeding on colonic regulatory gene expression in mice.cited 3×
chronic restraint stressor	Decreases - reduced	body weight	Animal	C57BL/6J mice	Not specified	Effect of chronic restraint stress and western-diet feeding on colonic regulatory gene expression in mice.cited 3×
cafeteria style western diet	No effect - was not associated with long-term changes in	body weight	Animal	rats	Cafeteria-style Western Diet (various high-fat/high-sugar foods) ad libitum.	Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling.cited 2×
zinc supplementation	No effect - no significant differences between groups	body weight	Human	pre-diabetic adults	30 mg zinc gluconate daily.	The effect of zinc supplementation on glucose homeostasis: a randomised double-blind placebo-controlled trial.cited 13×
antioxcin4	Decreases - decreased	body weight	HumanAnimalMolecular	WD-fed mice	2.5 mg/day/animal (mice); 100 μM (HepG2 cells).	Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems.cited 26×
early life western diet consumption	No effect - revealed no differences in	body weight	Animal	male and female rats	Free access to high-fat/high-sugar food and drink items.	Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats.
early life western diet consumption	No effect - revealed no differences in	body weight	Animal	male and female rats	Free access to high-fat/high-sugar food and drink items.	Early- but not late-adolescent Western diet consumption programs for long-lasting memory impairments in male but not female rats.
estradiol replacement	Decreases - reduced	body weight	Animal	OVX mice	Not specified for Western Diet; estradiol dosage not detailed.	Estradiol Protects Female ApoE KO Mice against Western-Diet-Induced Non-Alcoholic Steatohepatitis.cited 6×