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Evidence shows mixed or conflicting results for Vitamin D on Hypertension.
30 studies (26 claims)
Conflicting evidence
Typical effective dose 2000 (2000–2000) IUacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| vitamin D supplementation | No effect - no notable difference | gestational hypertension rate | Human | patients with polycystic ovary syndrome | Not specified | Effects of vitamin D supplementation on ovulation and pregnancy in women with polycystic ovary syndrome: a systematic review and meta-analysis.cited 11× |
| vitamin D supplementation | No effect - to prevent or treat | hypertension | Human | — | Not specified | Is there an association between vitamin D and hypertension?cited 8× |
| vitamin D deficiency | No effect - association with | metabolic syndrome, diabetes mellitus, cardiovascular disease and arterial hypertension | Human | — | Not specified | Is there an association between vitamin D and hypertension?cited 8× |
| vitamin D supplementation | No effect - does not decrease | hypertension | Human | generally healthy populations | Not specified | Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies.cited 23× |
| vitamin D supplementation | No effect - not associated with the risk for | hypertension | Human | — | Not specified | Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.cited 64× |
| low vitamin D concentrations | Increases - were associated with a higher risk for | hypertension | Human | — | Not specified | Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.cited 64× |
| vitamin D supplementation | No effect - did not show any benefit | hypertension | Human | — | Not specified | Association between vitamin D and cardiovascular health: Myth or Fact? A narrative review of the evidence.cited 5× |
| Vitamin D supplementation | Decreases - prophylactic effects varied with different risk populations, dosages, areas, etc. | preeclampsia and pregnancy-induced hypertension | Human | pregnant women at risk | Not specified in the abstract. | Comparative effectiveness of prophylactic strategies for preeclampsia: a network meta-analysis of randomized controlled trials.cited 23× |
| Vitamin D supplementation | Decreases - were as efficacious as calcium supplementation and aspirin in preventing | preeclampsia/pregnancy-induced hypertension | Human | pregnant women at risk | Not specified in the abstract. | Comparative effectiveness of prophylactic strategies for preeclampsia: a network meta-analysis of randomized controlled trials.cited 23× |
| Vitamin D supplementation | Decreases - reduce the risk of | preeclampsia/pregnancy-induced hypertension | Human | pregnant women at risk | Not specified in the abstract. | Comparative effectiveness of prophylactic strategies for preeclampsia: a network meta-analysis of randomized controlled trials.cited 23× |
| vitamin D | No effect - affects | arterial hypertension | Human | — | Not specified | Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D.cited 42× |
| vitamin D | Increases - suggests a relationship with | incident hypertension | Human | — | Not specified | Vitamin D and the cardiovascular system.cited 68× |
| vitamin D | No effect - showed no effect | incident hypertension | Human | Europeans aged ≥70 years | 2000 IU/day | Effects of vitamin D, omega-3 and a simple strength exercise programme in cardiovascular disease prevention: The DO-HEALTH randomized controlled trial.cited 4× |
| Vitamin D | No effect - was the only metabolite in common for | pre-eclampsia and gestational hypertension prediction | Human | — | Not specified | Prediction of pregnancy-related hypertensive disorders using metabolomics: a systematic review.cited 12× |
| vitamin D | Decreases - significant inverse association | prevalence of essential hypertension | Human | large-scale epidemiological studies | Not specified | Potential Beneficial Effects of Vitamin D in Coronary Artery Disease.cited 32× |
| vitamin D levels | No effect - no notable difference | nocturnal patterns of hypertension / non-dipper hypertension | Human | dipper and non-dipper groups | Not specified | Investigating the potential association between micronutrient levels and non-dipper hypertension patterns in the elderly population: A retrospective analysis. |
| low vitamin D levels | No effect - suggests strong links | hypertension | Human | — | Not mentioned. | Vitamin D and cardiovascular prevention.cited 23× |
| low vitamin D levels | Increases - is associated with | hypertension | Human | — | Not specified | Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives.cited 96× |
| oral vitamin D supplementation | No effect - has no effect | hypertension | HumanAnimal | — | Not specified | Sunlight Has Cardiovascular Benefits Independently of Vitamin D.cited 61× |
| high serum vitamin D levels | Decreases - reduced risk | hypertension | HumanAnimal | individuals | Not specified | Sunlight Has Cardiovascular Benefits Independently of Vitamin D.cited 61× |
| low serum vitamin D concentrations | Increases - more frequent | disorders as ischemic heart disease, heart attack, stroke, cardiac arrhythmia, and hypertension | Human | patients | — | Health outcomes of vitamin D. Part II. Role in prevention of diseases.cited 19× |
| adequate vitamin D status | Decreases - has been linked to decreased risks of developing | hypertension | Human | — | Not mentioned for Vitamin A. | Vitamin D: health panacea or false prophet?cited 38× |
| vitamin D deficiency | Increases - is an independent risk factor for | arterial hypertension and strokes | Human | — | Not specified | Vitamin D, arterial hypertension & cerebrovascular disease.cited 34× |
| vitamin D deficiency | Increases - potential association | CV disease, including hypertension and ischemic heart disease | Human | older adults | Mean vitamin D dose was 528 IU/day (calcium dosage not specified). | Extraskeletal effects of vitamin D in older adults: cardiovascular disease, mortality, mood, and cognition.cited 100× |
| vitamin D deficiency | No effect - relevant nongenetic factor | etiology of osteoporosis and hypertension | Human | — | Not specified | The relationship among hypertension, antihypertensive medications, and osteoporosis: a narrative review.cited 75× |
| vitamin D deficiency | Increases - linked to a higher risk | hypertension | Human | — | Not specified | Vitamin D: sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites.cited 82× |
| vitamin D deficiency | No effect - associations between | hypertension | Human | — | Not mentioned | Vitamin D and cardiovascular diseases: Causality.cited 63× |
| Vitamin D deficiency | No effect - has been associated with | pulmonary hypertension | Human | humans | Not available | Role of Vitamin D in Management of Diabetes and Unresolved Cardiovascular Diseases.cited 1× |
| vitamin D status | No effect - relationship | all terms of hypertension in pregnancy | Human | — | Not specified | Systematic Review of Vitamin D and Hypertensive Disorders of Pregnancy.cited 36× |
| vitamin D receptor (VDR) knockout | Increases - show an increased | hypertension | HumanAnimal | mice | Not specified | Latest Knowledge on the Role of Vitamin D in Hypertension.cited 30× |
| Vitamin D excess | Increases - may cause | intracranial hypertension | Human | — | Not specified | From epidemiology and neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D + all-trans retinoic acid + Temozolomide combination in treatment of GBM.cited 12× |
| vitamin D intake | No effect - correlation was demonstrated | occurrence of arterial hypertension | Human | — | Not specified | The dietary composition of women who delivered preterm and full-term infants.cited 3× |
| pure vitamin D supplementation | Decreases - have partially but not consistently shown beneficial effects on | cardiovascular risk factors such as arterial hypertension | Animal | — | Not specified | Vitamin D and cardiovascular disease: update and outlook.cited 29× |