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Evidence suggests Vitamin D mayincreaseBone health.
88 studies (62 claims)
Emerging evidence
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| a daily dose of 400 international units of vitamin D | Increases - has shown to be effective for improving | bone health | Human | infants | 400 international units (IU) daily. | Vitamin D prophylaxis in infancy.cited 18× |
| vitamin D combined with calcium | Increases - possible benefit | bone health | Human | — | 2000 mg calcium (combined with 800 IU vitamin D daily). | Vitamin D Supplementation in Military Personnel: A Systematic Review of Randomized Controlled Trials.cited 8× |
| calcium and vitamin D | No effect - traditional focus of nutritional supplementation for protection | bone health | Human | — | Not specified | Nutrition, bone, and aging: an integrative physiology approach.cited 32× |
| calcium and vitamin D | Increases - interventions for promoting | bone health | Human | — | Not specified | Calcium and vitamin D supplementation: when and why.cited 5× |
| calcium and vitamin D | Increases - to ensure | bone health | Human | adults aged ≥65 years | Not specified | Dietary supplements and disease prevention - a global overview.cited 134× |
| calcium and vitamin D | Increases - supplement their intake | bone health | Human | patients on these agents | Not specified | Drugs that may harm bone: Mitigating the risk.cited 14× |
| calcium and vitamin D | Increases - important | bone health | Human | athletes | Not specified | Considerations for the Consumption of Vitamin and Mineral Supplements in Athlete Populations.cited 10× |
| Calcium and Vitamin D | No effect - have confirmed and established roles | maintenance of proper bone health | Human | — | Not specified | B vitamins, homocysteine and bone health.cited 84× |
| vitamin D supplementation | Increases - critical for optimising | adolescent and early adult bone health | Human | — | Weekly high-dose vitamin D (exact dosage not specified). | Update: Vitamin Dcited 2× |
| Vitamin D deficiency | Decreases - has adverse impact on | bone health | Human | children living with HIV in sub-Saharan Africa | Weekly high-dose vitamin D (exact dosage not specified). | Update: Vitamin Dcited 2× |
| Vitamin D supplementation | No effect - is essential for | bone health | Human | — | Higher loading doses of vitamin D are needed for obese individuals to achieve normal serum levels (specific dosage not provided). | Vitamin D in obesity.cited 167× |
| Vitamin D supplementation | Increases - ensure optimal bone health | bone health | Human | population level and in patients with osteoporosis | 800-1000 IU/day for levels <50 nmol/L; upper safety limit of 10,000 IU/day. | Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).cited 193× |
| vitamin D supplementation | No effect - is essential for | bone health | Human | — | 400 IU/day for infants; supplementation beyond 1 year for high-risk groups. | Vitamin D in the healthy European paediatric population.cited 316× |
| vitamin D supplementation | No effect - required to maintain | bone health | Human | — | 12,000 IU, 24,000 IU, or 48,000 IU of vitamin D3 orally each month. | Vitamin D supplementation in older people (VDOP): Study protocol for a randomised controlled intervention trial with monthly oral dosing with 12,000 IU, 24,000 IU or 48,000 IU of vitamin D₃.cited 11× |
| Vitamin D supplementation | No effect - is essential for the maintenance of | bone health | Human | — | 400 IU/day (oral supplementation for infants up to 1 year). | Vitamin D in European children-statement from the European Academy of Paediatrics (EAP).cited 49× |
| Vitamin D supplementation | No effect - without substantial benefit | bone health | Human | sarcoidosis patients | Not specified | Current concepts regarding calcium metabolism and bone health in sarcoidosis.cited 19× |
| vitamin D supplementation | No effect - dose-dependent effects | bone health | Human | — | Not specified in the abstract. | Methods and procedures for: A randomized double-blind study investigating dose-dependent longitudinal effects of vitamin D supplementation on bone health.cited 10× |
| vitamin D supplementation | No effect - recommended | bone health | Human | general adult population | Not specified | Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors.cited 5× |
| vitamin D supplementation | No effect - suggested | bone health | Human | general adult population | Not specified | Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors.cited 5× |
| vitamin D supplementation | No effect - did not recommend | bone health | Human | general adult population | Not specified | Vitamin D recommendations in clinical guidelines: A systematic review, quality evaluation and analysis of potential predictors.cited 5× |
| vitamin D supplementation | No effect - recommended | bone health | Human | children 0-7 years | 80-320 IU daily for children 0-7 years; 720 IU daily for patients >8 years. | Osteoporosis and bone health in pediatric patients with epidermolysis bullosa: A scoping review.cited 1× |
| vitamin D supplementation | No effect - recommended | bone health | Human | patients >8 years | 80-320 IU daily for children 0-7 years; 720 IU daily for patients >8 years. | Osteoporosis and bone health in pediatric patients with epidermolysis bullosa: A scoping review.cited 1× |
| Vitamin D supplementation | No effect - maintaining | bone health | Human | healthy adults | Individualized dosing regimens (specific amounts not provided). | Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context.cited 1× |
| Vitamin D supplementation | No effect - maintaining | bone health | Human | individuals with osteopenia | Individualized dosing regimens (specific amounts not provided). | Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context.cited 1× |
| Vitamin D supplementation | No effect - maintaining | bone health | Human | osteoporosis patients | Individualized dosing regimens (specific amounts not provided). | Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context.cited 1× |
| Vitamin D supplementation | No effect - maintaining | bone health | Human | institutionalized older adults | Individualized dosing regimens (specific amounts not provided). | Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context.cited 1× |
| Vitamin D supplementation | No effect - maintaining | bone health | Human | individuals aged 18 and above | Individualized dosing regimens (specific amounts not provided). | Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context.cited 1× |
| vitamin D supplementation | No effect - showed no or even detrimental effects | muscle and bone health | Human | other patient populations | Not mentioned | Vitamin D in Osteosarcopenic Obesity.cited 43× |
| vitamin D supplementation | No effect - lack of data from robust randomised controlled trials | non-bone health outcomes | Human | — | 400 IU vitamin D₃ daily for infants at risk of low vitamin D. | Vitamin D and health in pregnancy, infants, children and adolescents in Australia and New Zealand: a position statement.cited 131× |
| Vitamin D supplementation | No effect - Randomized, controlled trials of vitamin D supplementation for pediatric bone health are limited and equivocal | pediatric bone health | Human | children | 10-50 μg/day | Vitamin D in Toddlers, Preschool Children, and Adolescents.cited 38× |
| Vitamin D supplements | No effect - are widely recommended | bone health | Human | the general population | Not specified in the abstract. | Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults.cited 167× |
| vitamin D | Increases - may play a pivotal role | bone health | Human | — | 20 μg (800 IU) vitamin D daily (calcium dosage not specified) | Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe.cited 84× |
| vitamin D | No effect - involvement in | bone health | Human | — | Not specified | Outcomes of Vitamin D Supplementation in Adults Who are Deficient and Critically Ill: A Review of the Literature.cited 9× |
| vitamin D | Increases - some benefit | bone health | Human | adults with epilepsy | Higher doses (>1800 IU) were suggested for future trials, but specific dosages were not detailed in the abstract. | Vitamin D supplementation for bone health in adults with epilepsy: A systematic review.cited 15× |
| Vitamin D | No effect - maintaining | bone health | Human | — | Not specified | Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention.cited 8× |
| vitamin D | No effect - has an undisputed role | bone health | Human | — | Not specified | Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus.cited 87× |
| vitamin D | No effect - important for | bone health | Human | — | — | Vitamin D and health: the need for more randomized controlled trials.cited 37× |
| vitamin D | Increases - synergies | bone health | Human | — | Not specified | 25-Hydroxyvitamin D as a Biomarker of Vitamin D Status and Its Modeling to Inform Strategies for Prevention of Vitamin D Deficiency within the Population.cited 88× |
| vitamin D | Increases - Evidence to support the role | bone health | Human | — | Not specified | Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations.cited 7× |
| vitamin D | No effect - has a role | bone health | Human | — | 600-800 IU of native vitamin D3 (recommended standard dose for the healthy population). | Vitamin D in critical care: where are we now and what is next?cited 8× |
| vitamin D | Increases - remain an important part of | bone health | Human | — | Not specified | Osteoporosis diagnosis and medical treatment.cited 21× |
| vitamin D | No effect - preserving | bone health | Human | — | — | Vitamin D and thyroid disease: to D or not to D?cited 68× |
| vitamin D | No effect - preserving | bone health | HumanMolecular | — | Not mentioned | Focus on vitamin D and the adrenal gland.cited 36× |
| vitamin D | No effect - plays a pivotal role in | bone health | Human | pediatric age | Not specified | Vitamin D in childhood and adolescence: an expert position statement.cited 122× |
| vitamin D | No effect - essential nutrients for | bone health | Human | — | Not specified | Calcium and Vitamin D Deficiency in Vietnamese: Recommendations for an Intervention Strategy.cited 13× |
| vitamin D | No effect - plays an essential role in maintaining | bone health | HumanMolecular | — | Not specified | INFLUENCE OF VITAMIN D ON HUMAN HEALTH (REVIEW).cited 2× |
| vitamin D deficiency | Decreases - is associated with deteriorating | bone health | HumanMolecular | — | Not specified | INFLUENCE OF VITAMIN D ON HUMAN HEALTH (REVIEW).cited 2× |
| Vitamin D | No effect - is critical for | bone health | Human | — | Not specified | Chronic Atrophic Autoimmune Gastritis: The Evolving Role of Vitamin D. |
| vitamin D | Increases - positively affected | bone health | Human | — | Not specified | The role of carotenoids in bone health-A narrative review.cited 7× |
| vitamin D | Increases - can be recommended for proper maintenance | bone health | Human | postmenopausal women | — | A review of select vitamins and minerals used by postmenopausal women.cited 31× |
| Vitamin D | No effect - is important for | bone health | Human | — | Not specified | Vitamin D Supplementation in Patients with Juvenile Idiopathic Arthritis.cited 8× |
| vitamin D | No effect - linked to | bone health | Human | people with multiple sclerosis (MS) | Not specified | Management of Osteoporosis, Fracture and Falls in People with Multiple Sclerosis: Systematic Review of Guidelines.cited 1× |
| Vitamin D | No effect - plays important roles in | bone health | Human | — | Not specified | Correlation between vitamin D metabolic pathway-related gene polymorphisms and cardiovascular disease.cited 2× |
| Vitamin D | No effect - plays a critical role | bone health | Human | — | Not specified | Relationship between vitamin D deficiency and gestational diabetes: a narrative review.cited 1× |
| Vitamin D | No effect - pivotal role in | bone health | Human | — | Not specified | Unlocking the Potential of Vitamin D: A Comprehensive Exploration of Its Role in Neurological Health and Diseases. |
| Vitamin D | No effect - has been appreciated beyond | bone health and calcium metabolism | Human | — | Not specified | Vitamin D and Respiratory Diseases : Based on 11th Dr. I. C. Verma Excellence in Research Award for Young Pediatricians Delivered as Oration on 15th Oct. 2023. |
| vitamin D | No effect - is known for its essential role | calcium homeostasis and bone health | Human | — | Not mentioned | Vitamin D in schizophrenia: a clinical review.cited 57× |
| Vitamin D | No effect - is a versatile signaling molecule with an established role in the regulation | calcium homeostasis and bone health | Human | — | Not specified | Possible influence of vitamin D on male reproduction.cited 48× |
| vitamin D | No effect - negative results from large, recent trials, particularly those with | fractures and bone health outcomes | Human | — | Not mentioned | Vitamin D-Do Diet Recommendations for Health Remain Strong? |
| Vitamin D (VitD) | Increases - known to have a positive impact | muscle and bone health | Human | — | Not specified | Targeting the Hallmarks of Aging with Vitamin D: Starting to Decode the Myth.cited 5× |
| bisphosphonate therapy in addition to calcium and vitamin D supplements | Increases - should be considered for | bone health | Human | women with a Z-score <-2.0 or Z-score ≤-1.0 and/or a 5-10% annual decrease in bone mineral density | Daily calcium supplementation (specific dosage not mentioned). | Cancer treatment-induced bone loss in premenopausal women: a need for therapeutic intervention?cited 69× |
| regular exercise and daily calcium and vitamin D supplementation | Increases - are recommended | bone health | Human | premenopausal women with breast cancer | Daily calcium supplementation (specific dosage not mentioned). | Cancer treatment-induced bone loss in premenopausal women: a need for therapeutic intervention?cited 69× |
| Vitamin D deficiency treatment | Increases - should be suspected and treated | bone health | Human | all subjects with osteopenia or osteoporosis | Not specified | Updated recommendations for the diagnosis and management of osteoporosis: a local perspective.cited 21× |
| vitamin D and calcium supplementation | No effect - treatment options are limited to | bone health abnormalities | Human | patients with inflammatory bowel disease | Not specified | Pediatric inflammatory bowel disease and bone health.cited 5× |
| supplementation of vitamin D | Increases - improve | bone health | Human | patients receiving ADT | Not specified | Adverse effects of androgen deprivation therapy in patients with prostate cancer: Focus on muscle and bone health.cited 16× |
| vitamin D alone | No effect - correlation is overall inconclusive | bone health | Human | — | Not specified | Vitamin D and calcium: what do we need to know?cited 2× |
| calcium and vitamin D supplementation | No effect - synergistic roles in maintaining | bone health | Human | postmenopausal women | Not specified | Vitamin D and calcium: what do we need to know?cited 2× |
| supplementation of calcium and vitamin D | Increases - may be helpful | poor bone health | Human | patients with epidermolysis bullosa (EB) | Not specified | Osteopenia and osteoporosis in epidermolysis bullosa.cited 16× |
| Maternal intake of dairy foods rich in high-quality proteins, calcium, and vitamin D | No effect - may influence | later bone health status | Human | offspring | Not specified | Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial.cited 20× |
| red cell transfusion, vitamin D and calcium supplementation | Increases - importance of appropriate management, including ... for improved | long-term bone health | Human | adolescents with NTD Hb E/β-thalassemia | Not specified | Prevalence of low bone mass among adolescents with nontransfusion-dependent hemoglobin E/β-thalassemia and its relationship with anemia severity.cited 11× |
| Higher maternal dietary protein and calcium intakes than usual care in concert with normal vitamin D status | No effect - may protect | bone health | Human | maternal participants during pregnancy | Individualized high dairy protein diet (specific amounts not detailed). | Individualized high dairy protein + walking program supports bone health in pregnancy: a randomized controlled trial.cited 5× |
| Physical therapy, vitamin D supplementation, and other interventions | Increases - are also important tools | optimal bone health perioperatively and for satisfactory surgical outcomes | Human | — | Not specified | Perioperative Evaluation and Management of Children with Osteoporosis and Low Bone Mineral Density. |
| calcium and vitamin D supplementation (400 IU/day) | No effect - was not enough to achieve | 25(OH)D concentration considered optimal for bone health | Human | postmenopausal women with osteoporosis | 1,200 mg calcium carbonate and 400 IU vitamin D3 daily. | Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?cited 16× |
| calcium and vitamin D supplementation | Increases - be prescribed | bone health | Human | patients assessed for fracture risk | Not specified | Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).cited 18× |
| calcium and vitamin D supplementation | Increases - should be included | bone health | Human | all patients with chronic liver disease | — | Osteoporosis and fractures in liver disease: relevance, pathogenesis and therapeutic implications.cited 75× |
| calcium and vitamin D supplementation | Increases - initiating when low are the first approaches to optimizing | bone health | Human | individuals with Rett syndrome | Not specified | Clinical Guidelines for Management of Bone Health in Rett Syndrome Based on Expert Consensus and Available Evidence.cited 39× |
| calcium and vitamin D supplementation | No effect - best studied | bone health and fracture prevention | Human | critically ill populations | Not specified | Micronutrient intake to protect against osteoporosis during and after critical illness.cited 5× |
| a targeted, multi-component resistance and impact-loading exercise programme together with a daily protein-, calcium- and vitamin D-enriched supplement | No effect - examine the efficacy | bone health | Human | men treated with ADT for prostate cancer | Not specified | Efficacy of a multi-component exercise programme and nutritional supplementation on musculoskeletal health in men treated with androgen deprivation therapy for prostate cancer (IMPACT): study protocol of a randomised controlled trial.cited 18× |
| supplemental calcium (Ca) and vitamin D provided daily throughout IMT | Increases - improved | measures of bone health | Human | young adults entering IMT | 2000 mg calcium and 1000 IU vitamin D daily. | Association Between Single Gene Polymorphisms and Bone Biomarkers and Response to Calcium and Vitamin D Supplementation in Young Adults Undergoing Military Training.cited 20× |
| Vitamin D and calcium supplements | No effect - commonly used, often together, to optimize | bone health | Human | — | Not specified. | Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar.cited 53× |
| vitamin D and calcium | Increases - prescribing prophylactically | bone health | Human | high-risk patients | 1,000 to 1,200 mg of calcium per day; 800 to 2,000 IU of vitamin D3 daily. | Current concept review: vitamin D and stress fractures.cited 41× |
| 600 to 800 IU of vitamin D | Increases - required | adequate bone health | Human | most adults | 1,000 to 1,200 mg of calcium per day; 800 to 2,000 IU of vitamin D3 daily. | Current concept review: vitamin D and stress fractures.cited 41× |
| vitamin D supplementation in pregnancy | Increases - optimal strategy | offspring bone health | Human | offspring | Not specified | Prenatal calcium and vitamin D intake, and bone mass in later life.cited 18× |
| vitamin D supplementation with or without calcium | No effect - assess the effects of supplementation | bone health outcomes | Human | community-dwelling adults | Greater than 400 IU vitamin D3 and greater than 1000 mg calcium (for postmenopausal women); ≤400 IU vitamin D3 and ≤1000 mg calcium (not recommended). | Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement.cited 159× |
| inflammatory process and malabsorption of calcium and vitamin D | Decreases - negatively affected | bone health | Human | adults and children with celiac disease | Not specified | Management of bone health in patients with celiac disease: Practical guide for clinicians.cited 17× |
| supplementation of calcium, vitamin D | Increases - help maintain good bone health | bone health | Human | regularly transfused beta-thalassemia major patients | Not specified | An Evaluation of Bone Health Parameters in Regularly Transfused Beta-Thalassemia Major Patients.cited 5× |
| 12-week, 24-session TLM program of individualized health monitoring, group health education, exercise, and calcium-vitamin D supplementation | Increases - can be effective in improving | health behaviors to maintain bone health | Human | women at high risk of osteoporosis | Not specified | Effects of a three-month therapeutic lifestyle modification program to improve bone health in postmenopausal Korean women in a rural community: a randomized controlled trial.cited 30× |
| vitamin D deficiency | Decreases - strong negative impact | bone health | Human | — | Not specified. | Crucial Role of Vitamin D in the Musculoskeletal System.cited 142× |
| vitamin D deficiency | Decreases - adverse impact | bone health | Human | breast cancer survivors | Not specified | Vitamin D and breast cancer.cited 83× |
| Vitamin D deficiency | Decreases - has a further adverse impact on | bone health | Human | children living with HIV in sub-Saharan Africa | Weekly high-dose vitamin D (specific amount not mentioned). | Vitamin Dcited 10× |
| vitamin D (VD) deficiency | Decreases - inhibits | the body's capacity to absorb calcium and maintain optimal bone health | Human | — | Not specified | Osteoporosis and dermatoporosis: a review on the role of vitamin D.cited 17× |
| Current vitamin D guidelines | No effect - based on optimizing | markers of bone health | Human | — | Not specified | Vitamin D in dialysis: defining deficiency and rationale for supplementation.cited 20× |
| Adequate vitamin D | No effect - needed for | bone health | Human | children and adults | Not specified (sunlight exposure varies; 400 IU vitamin D daily mentioned for infants). | Ultraviolet radiation: a hazard to children and adolescents.cited 169× |
| oral calcium, vitamin D(3) and DHA | Increases - positive effect | bone health | Human | osteopenic individuals | 1200 mg calcium carbonate with 1000 IU vitamin D₃ daily | Efficacy and tolerability of calcium, vitamin D and a plant-based omega-3 oil for osteopenia: a pilot RCT.cited 15× |
| adequate calcium and vitamin D supplementation | Increases - have been documented to have good impact in long-term | bone health | Human | postmenopausal women receiving AIs | Not specified | Management of bone loss in postmenopausal breast cancer patients treated with aromatase inhibitors.cited 13× |
| Calcium plus vitamin D supplementation | Increases - may promote | bone health | Human | older population | — | The cardiovascular safety aspects of calcium supplementations: where does the truth lie? A personal perspective. |
| maternal Vitamin D | No effect - underlined the important role of | bone health | Human | the offspring | Not specified | "You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes.cited 7× |