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Evidence suggests Red Light Therapy maydecreaseDepression.
113 studies (149 claims)
Moderate consensus
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| light therapy + antidepressant drugs | Decreases - was superior to | depression score | Human | participants with a moderate to severe major depressive episode | Not specified | Efficacy of light therapy versus antidepressant drugs, and of the combination versus monotherapy, in major depressive episodes: A systematic review and meta-analysis.cited 51× |
| light therapy + antidepressant drugs | Decreases - superiority was confirmed | depression score | Human | patients with non-seasonal depression | Not specified | Efficacy of light therapy versus antidepressant drugs, and of the combination versus monotherapy, in major depressive episodes: A systematic review and meta-analysis.cited 51× |
| light therapy | Decreases - has been shown to be efficient | seasonal and non-seasonal depression | Human | — | Not specified | Efficacy of light therapy versus antidepressant drugs, and of the combination versus monotherapy, in major depressive episodes: A systematic review and meta-analysis.cited 51× |
| light therapy + Placebo | Decreases - superiority (lower depression score) ... was non-significant | depression score | Human | participants with a moderate to severe major depressive episode | Not specified | Efficacy of light therapy versus antidepressant drugs, and of the combination versus monotherapy, in major depressive episodes: A systematic review and meta-analysis.cited 51× |
| Bright Light Therapy (BLT) | No effect - are secondary outcomes | alternative depression measures | Human | subjects with idiopathic PD | 30 minutes of light therapy twice daily | A double-blind randomized controlled trial to assess the effect of bright light therapy on depression in patients with Parkinson's disease.cited 13× |
| Bright Light Therapy (BLT) | Decreases - might be a new treatment option | depression | Human | patients with Parkinson's disease (PD) | 30 minutes of light therapy twice daily | A double-blind randomized controlled trial to assess the effect of bright light therapy on depression in patients with Parkinson's disease.cited 13× |
| Bright light therapy | Decreases - reduced antenatal depression | antenatal depression | Human | pregnant women with depression or anxiety | Not specified | The effect of complementary medicines and therapies on maternal anxiety and depression in pregnancy: A systematic review and meta-analysis.cited 46× |
| Bright-light therapy (BLT) | No effect - has evidence for efficacy | antepartum depression | Human | — | Not specified | Bright-light therapy in the treatment of mood disorders.cited 177× |
| Bright-light therapy (BLT) | No effect - has evidence for efficacy | bipolar depression | Human | — | Not specified | Bright-light therapy in the treatment of mood disorders.cited 177× |
| Bright-light therapy (BLT) | No effect - has evidence for efficacy | chronic depression | Human | — | Not specified | Bright-light therapy in the treatment of mood disorders.cited 177× |
| Bright-light therapy (BLT) | No effect - data on the usefulness are promising | non-seasonal depression | Human | — | Not specified | Bright-light therapy in the treatment of mood disorders.cited 177× |
| Bright-light therapy (BLT) | No effect - has evidence for efficacy | premenstrual depression | Human | — | Not specified | Bright-light therapy in the treatment of mood disorders.cited 177× |
| bright light therapy (BLT) | Decreases - summarizes the applications | antepartum depression, childhood and adolescence depression | Human | patients suffering from eating disorders | Not specified | Bright light therapy in the treatment of childhood and adolescence depression, antepartum depression, and eating disorders.cited 17× |
| bright light therapy (BLT) | Decreases - may be a useful alternative or adjunctive therapy | depression or eating disorders | Human | these patient subpopulations | Not specified | Bright light therapy in the treatment of childhood and adolescence depression, antepartum depression, and eating disorders.cited 17× |
| bright light therapy (BLT) | No effect - obtained | Beck Depression Inventory-II (BDI-II) scores | Human | middle-aged and older adults receiving long-term hemodialysis | 30-minute sessions of BLT five times a week. | Effect of Bright Light Therapy on Depressive Symptoms in Middle-Aged and Older Patients Receiving Long-Term Hemodialysis.cited 1× |
| Bright light therapy (BLT) | Decreases - showed a greater ameliorative effect | bipolar depression | Human | patients with acute bipolar depression | Not applicable (study used light therapy, not DIM). | Clinical efficacy, onset time and safety of bright light therapy in acute bipolar depression as an adjunctive therapy: A randomized controlled trial.cited 30× |
| bright light therapy (BLT) | Decreases - is an effective and safe add-on treatment | bipolar depression (BD) | Human | — | BLT (10000 lux) or DL (<500 lux) administered each morning for 30 minutes. | Efficacy of bright light therapy in bipolar depression.cited 35× |
| bright light therapy (BLT) | Decreases - statistically significant reductions in depression scores | depression scores | Human | BD outpatients | BLT (10000 lux) or DL (<500 lux) administered each morning for 30 minutes. | Efficacy of bright light therapy in bipolar depression.cited 35× |
| bright light therapy (BLT) | Decreases - significant efficiency | bipolar depression | Human | patients with BD depression | Light intensity ≥5000 lux (specific frequency not detailed). | Bright light therapy in the treatment of patients with bipolar disorder: A systematic review and meta-analysis.cited 13× |
| bright light therapy (BLT) | Decreases - significant differences between BLT and placebo | depression severity before and after BLT | Human | patients with BD depression | Light intensity ≥5000 lux (specific frequency not detailed). | Bright light therapy in the treatment of patients with bipolar disorder: A systematic review and meta-analysis.cited 13× |
| bright light therapy (BLT) | Decreases - significant differences between BLT and placebo | depression severity before and after BLT | Human | patients with BD depression | Light intensity ≥5000 lux (specific frequency not detailed). | Bright light therapy in the treatment of patients with bipolar disorder: A systematic review and meta-analysis.cited 13× |
| bright light therapy | Increases - positive effects | depression | Human | persons with Parkinson's disease (PwP) | Not specified | The multimodal effect of circadian interventions in Parkinson's disease: A narrative review.cited 3× |
| light therapy | Increases - induced improvements | depression | Human | persons with Parkinson's disease (PwP) | Not specified | The multimodal effect of circadian interventions in Parkinson's disease: A narrative review.cited 3× |
| Bright Light Therapy (BLT) | Decreases - positive treatment effect | depression | Human | adults | Not Assessed | Light Therapy for Adolescent Depression: A Scoping Review.cited 4× |
| Bright light therapy (BLT) | Decreases - effective in | depression | Human | — | Not specified | Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the "Life-ON" project.cited 17× |
| Bright light therapy (BLT) | Decreases - investigate the effectiveness of | perinatal depression (PND) | Human | women | Not specified | Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the "Life-ON" project.cited 17× |
| Bright light therapy (BLT) | Decreases - test whether a short term trial of BLT during pregnancy can prevent | perinatal depression (PND) | Human | women | Not specified | Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the "Life-ON" project.cited 17× |
| Bright light therapy (BLT) | Decreases - confirm the safety and efficacy of | perinatal depression (PND) | Human | a large sample of women | Not specified | Chronobiology, sleep-related risk factors and light therapy in perinatal depression: the "Life-ON" project.cited 17× |
| Bright light therapy (BLT) | No effect - evidence of its antidepressant efficacy | depression | Human | — | Not specified | Bright light therapy for depression: a review of its effects on chronobiology and the autonomic nervous system.cited 74× |
| Bright light therapy (BLT) | No effect - review the chronobiological effects | depression | Human | depressed and non-depressed individuals | Not specified | Bright light therapy for depression: a review of its effects on chronobiology and the autonomic nervous system.cited 74× |
| Bright light therapy (BLT) | No effect - supports its use | other neuropsychiatric conditions including non-seasonal depression | Human | — | Not specified | Bright light therapy for depression: a review of its effects on chronobiology and the autonomic nervous system.cited 74× |
| Bright light therapy (BLT) | Decreases - is an effective intervention | depression | Human | the general population | Not available | A multicenter randomized controlled trial for bright light therapy in adults with intellectual disabilities and depression: Study protocol and obstacle management.cited 7× |
| Bright light therapy (BLT) | Decreases - is an effective intervention | non-seasonal depression | Human | the general population | Not available | A multicenter randomized controlled trial for bright light therapy in adults with intellectual disabilities and depression: Study protocol and obstacle management.cited 7× |
| Bright light therapy (BLT) | Decreases - is an effective intervention | seasonal depression | Human | the general population | Not available | A multicenter randomized controlled trial for bright light therapy in adults with intellectual disabilities and depression: Study protocol and obstacle management.cited 7× |
| bright light therapy | Decreases - is an equally effective intervention | depression | Human | persons with both mild/moderate and severe dementia | Not specified | Bright Light Therapy to Treat Depression in Individuals with Mild/Moderate or Severe Dementia.cited 17× |
| bright light therapy | Decreases - supports the use | depression | Human | persons regardless of dementia severity | Not specified | Bright Light Therapy to Treat Depression in Individuals with Mild/Moderate or Severe Dementia.cited 17× |
| bright light therapy (BLT) | Decreases - encouraging | depression | Human | unipolar depression | Not specified | Sleep and major depressive disorder: a review of non-pharmacological chronotherapeutic treatments for unipolar depression.cited 21× |
| bright light therapy (BLT) | Decreases - encouraging | depression | Human | geriatric patients | Not specified | Sleep and major depressive disorder: a review of non-pharmacological chronotherapeutic treatments for unipolar depression.cited 21× |
| bright light therapy (BLT) | Decreases - encouraging | depression | Human | perinatal patients | Not specified | Sleep and major depressive disorder: a review of non-pharmacological chronotherapeutic treatments for unipolar depression.cited 21× |
| bright light therapy | Decreases - positive findings | depression | Human | persons with neurocognitive disorders | Not specified | Management of Late-Life Depression in the Context of Cognitive Impairment: a Review of the Recent Literature.cited 23× |
| bright light therapy | Decreases - effective for the treatment | depression | Human | patients with poststroke insomnia | — | The Effect of Bright Light Therapy on Sleep and Quality of Life in Patients With Poststroke Insomnia.cited 13× |
| bright light therapy | Decreases - revealing a medium-to-large post-treatment effect | depression | Human | — | — | Psychological and behavioural interventions in bipolar disorder that target sleep and circadian rhythms: A systematic review of randomised controlled trials.cited 14× |
| bright light therapy (BLT) | Decreases - reducing | depression | Human | cancer patients | ≥10,000 lx (intensity not further specified). | Effect of bright light therapy on cancer-related fatigue and related symptoms: A systematic review and meta-analysis of randomized controlled trials.cited 3× |
| bright light therapy | Decreases - suppressed significantly | depression | Human | a 68-year-old woman with a 2-year history of AD | 30 minutes twice a day (8:30 am to 9:00 am and 16:30 pm to 17:00 pm). | Effect of bright-light therapy on depression and anxiety of a patient with Alzheimer's disease combined with sleep disorder: A case report. |
| bright light therapy | Decreases - Antidepressant effects were identified | depression | Human | patients with seasonal affective disorder | Not specified | Manipulating melatonin in managing mood. |
| bright light therapy | Decreases - Antidepressant effects were identified | depression | Human | patients with seasonal affective disorder | Not specified | Manipulating melatonin in managing mood. |
| bright light therapy | Decreases - a potential role was found for | depression | Human | those with Bulimia Nervosa | Not specified | The role of complementary and alternative medicine in the treatment of eating disorders: A systematic review.cited 19× |
| bright light therapy (BLT) | Increases - significant improvement | depression outcomes | Human | participants diagnosed with perinatal depression | Not specified | Efficacy of bright light therapy improves outcomes of perinatal depression: A systematic review and meta-analysis of randomized controlled trials. |
| bright light therapy (BLT) | Increases - beneficial impact | perinatal depression | Human | participants diagnosed with perinatal depression | Not specified | Efficacy of bright light therapy improves outcomes of perinatal depression: A systematic review and meta-analysis of randomized controlled trials. |
| bright light therapy (BLT) | Increases - increased relative risk | perinatal depression | Human | participants diagnosed with perinatal depression | Not specified | Efficacy of bright light therapy improves outcomes of perinatal depression: A systematic review and meta-analysis of randomized controlled trials. |
| Bright light (BL) therapy | Decreases - trended toward improvements | depression per self-report | Human | ovarian or endometrial cancer survivors | 45 minutes of BL or DL daily | Feasibility and Preliminary Efficacy of a Bright Light Intervention in Ovarian and Endometrial Cancer Survivors.cited 15× |
| Bright light (BL) therapy | Decreases - improved from T1 to T2 before returning to baseline at T3 | depression per self-report | Human | ovarian or endometrial cancer survivors | 45 minutes of BL or DL daily | Feasibility and Preliminary Efficacy of a Bright Light Intervention in Ovarian and Endometrial Cancer Survivors.cited 15× |
| Bright light therapy (BLT) | Decreases - was superior over placebo | depression ratings | Human | adults with seasonal affective disorder (SAD) | Bright light therapy (≥1,000 lx) via light box or light visor. | The Efficacy of Light Therapy in the Treatment of Seasonal Affective Disorder: A Meta-Analysis of Randomized Controlled Trials.cited 69× |
| bright light therapy | Increases - Changes in the depression score were also higher | depression score | Human | CNBP patients | 5,000 lx (active treatment) or 230 lx (sham) for 3 supplementary light exposures over 3 weeks. | Short-term effects of bright light therapy in adults with chronic nonspecific back pain: a randomized controlled trial.cited 21× |
| bright light therapy | Decreases - significantly reduced | depression scores | Human | adults with medically intractable focal epilepsy | High-intensity and low-intensity light boxes (specific lux values not provided), daily use. | Bright light therapy for symptoms of anxiety and depression in focal epilepsy: randomised controlled trial.cited 18× |
| bright light therapy | No effect - did not significantly alter | depression scores | Human | women experiencing perinatal depression | Not specified | Effect of Bright Light Therapy on Perinatal Depression: A Systematic Review and Meta-Analysis: Effet de la luminothérapie sur la dépression périnatale: une revue systématique et une méta-analyse. |
| Bright light therapy | Decreases - is an effective treatment for reducing | depression symptoms | Human | patients with bipolar depression | Not specified in the abstract. | Adjunctive bright light therapy for treating bipolar depression: A systematic review and meta-analysis of randomized controlled trials.cited 20× |
| augmentation treatment with light therapy | Decreases - significantly decreased | the severity of bipolar depression | Human | — | Not specified in the abstract. | Adjunctive bright light therapy for treating bipolar depression: A systematic review and meta-analysis of randomized controlled trials.cited 20× |
| bright light therapy (BLT) | Decreases - significantly improved | depression symptoms (BDI, GDS-30, HDRS and HADS) | Human | patients with PD | — | The effects of bright light therapy on depression and sleep disturbances in patients with Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.cited 29× |
| bright light therapy (BLT) | Decreases - supports the usefulness | irritability in bipolar depression | Human | inpatients | Not specified | The effect of bright light therapy on irritability in bipolar depression: a single-blind randomised control trial. |
| bright-light therapy | Decreases - was effective | late-life depression | Human | adults aged 60 years or older in primary care | Not specified | Non-pharmacological treatment for depressed older patients in primary care: A systematic review and meta-analysis.cited 45× |
| Bright light therapy (BLT) | Increases - is an emerging therapy for | major depression | Human | — | Not specified in the abstract. | Bright light therapy versus physical exercise to prevent co-morbid depression and obesity in adolescents and young adults with attention-deficit / hyperactivity disorder: study protocol for a randomized controlled trial.cited 22× |
| bright light therapy (BLT) | No effect - effects in | major depressive disorder, non-seasonal depression, bipolar depression or depressive phase of bipolar disorder, and seasonal affective disorder | Human | — | Not specified | Illuminating the way: the role of bright light therapy in the treatment of depression.cited 3× |
| bright light therapy (BLT) | No effect - effects in | treatment-resistant depression (TRD) | Human | — | Not specified | Illuminating the way: the role of bright light therapy in the treatment of depression.cited 3× |
| bright light therapy | Decreases - had a significantly greater change | mean depression scores | Human | 27 women | Not specified for all interventions; omega-3 was administered over eight weeks in one trial. | Interventions (other than pharmacological, psychosocial or psychological) for treating antenatal depression.cited 58× |
| Bright light therapy (BLT) | Decreases - decreased | median depression scores | Human | pregnant women with a DSM-5 diagnosis of depressive disorder | DRLT (100 lux, 2700 K) administered daily for 30 minutes upon awakening. | Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial.cited 17× |
| dim red light therapy (DRLT) | Decreases - decreased | median depression scores | Human | pregnant women with a DSM-5 diagnosis of depressive disorder | DRLT (100 lux, 2700 K) administered daily for 30 minutes upon awakening. | Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial.cited 17× |
| Bright light therapy | No effect - Efficacy includes | nonseasonal depression | Human | — | Not specified | The psychiatry of light.cited 13× |
| bright light therapy | No effect - may be reasonable to consider | perinatal depression | Human | women during pregnancy or postpartum | Not specified | Complementary and alternative medicine therapies for perinatal depression.cited 58× |
| Bright light therapy (BLT) | Decreases - achieved remission | perinatal depression (PND) | Human | women with an EPDS >12 from the 2nd gestational trimester until 9 months postpartum | 30 minutes of morning BLT (10,000 lux) or DRL (19 lux). | Sustained remission from perinatal depression after bright light therapy: A pilot randomised, placebo-controlled trial.cited 20× |
| bright light therapy | Decreases - may be an attractive treatment | perinatal depression | Human | childbearing women | Not specified | Efficacy of light therapy for perinatal depression: a review.cited 35× |
| bright light therapy | Decreases - treatable with | residual symptoms of bipolar depression | Human | women with bipolar disorder | Not specified | Treatment of Peripartum Bipolar Disorder.cited 31× |
| Bright light therapy (BLT) | No effect - is efficacious for | seasonal and non-seasonal depression | Human | — | Not specified | Delivery of bright light therapy within the Veterans Health Administration. |
| Bright light therapy (BLT) | Increases - supports the efficacy | seasonal and non-seasonal depression | Human | — | Not specified | Bright light therapy for mental and behavioral illness: A systematic umbrella review.cited 3× |
| Bright light therapy (BLT) | Increases - outperformed | seasonal or non-seasonal depression | Human | — | Not specified | Bright light therapy for mental and behavioral illness: A systematic umbrella review.cited 3× |
| bright light therapy | Decreases - has demonstrated efficacy and is an accepted treatment | seasonal depression | Human | — | ≥ 5,000 lux for ≥ 30 minutes. | Bright Light Therapy as Augmentation of Pharmacotherapy for Treatment of Depression: A Systematic Review and Meta-Analysis.cited 63× |
| bright light therapy ≥ 5,000 lux for periods ≥ 30 minutes when used as augmentation to standard antidepressant pharmacotherapy | Decreases - provides evidence for the efficacy | major depressive disorder and bipolar depression without a seasonal pattern | Human | — | ≥ 5,000 lux for ≥ 30 minutes. | Bright Light Therapy as Augmentation of Pharmacotherapy for Treatment of Depression: A Systematic Review and Meta-Analysis.cited 63× |
| bright light therapy | Decreases - significantly greater reduction | self-report depression scores on the BDI-II | Human | patients with seasonal affective disorder | 1 hour of bright light therapy and 1 hour of placebo dim red light. | Improvement in depression scores after 1 hour of light therapy treatment in patients with seasonal affective disorder.cited 16× |
| bright light therapy | Decreases - significantly greater reduction | self-report depression scores on the POMS-D | Human | patients with seasonal affective disorder | 1 hour of bright light therapy and 1 hour of placebo dim red light. | Improvement in depression scores after 1 hour of light therapy treatment in patients with seasonal affective disorder.cited 16× |
| bright light therapy (BLT) | Decreases - prevention | subthreshold depression symptoms | Human | individuals with subthreshold depression symptoms | Not specified in the abstract. | Increased functional connectivity between the midbrain and frontal cortex following bright light therapy in subthreshold depression: A randomized clinical trial.cited 8× |
| bright-light therapy | Decreases - were used in managing symptoms | symptoms associated with depression | Human | — | Not specified | What can low and high technologies do for late-life mental disorders?cited 16× |
| bright-light therapy | No effect - turned to | symptoms of depression | Human | people with symptoms of depression | Not specified | Treatment of Mood and Depressive Disorders With Complementary and Alternative Medicine: Efficacy Review.cited 4× |
| bright light therapy | No effect - not sufficiently supported by the evidence, but should be considered as good clinical practice | treatment of difficult-to-treat-depression (DTD) | Human | patients with difficult-to-treat-depression (DTD) | — | Treatment of difficult-to-treat depression - clinical guideline for selected interventions.cited 8× |
| cognitive behavioral therapy (CBT) as an additive treatment to light therapy (LT) | Decreases - decreased significantly more | anxiety and depression scores | Human | participants aged 16 to 26 years | Not specified | Cognitive Behavioral Therapy as an Adjunct Treatment to Light Therapy for Delayed Sleep Phase Disorder in Young Adults: A Randomized Controlled Feasibility Study.cited 33× |
| light therapy with intensity of 2,500 lux or greater | Decreases - has a greater effect on | depression | Human | cognitively impaired persons | Light intensity of 2,500 lux or greater (specific frequency not mentioned) | Effectiveness of Light Therapy in Cognitively Impaired Persons: A Metaanalysis of Randomized Controlled Trials.cited 19× |
| light therapy | Decreases - has a moderate effect on | depression | Human | cognitively impaired persons | Light intensity of 2,500 lux or greater (specific frequency not mentioned) | Effectiveness of Light Therapy in Cognitively Impaired Persons: A Metaanalysis of Randomized Controlled Trials.cited 19× |
| light therapy | Decreases - can alleviate symptoms of | depression | Human | cognitively impaired persons | Light intensity of 2,500 lux or greater (specific frequency not mentioned) | Effectiveness of Light Therapy in Cognitively Impaired Persons: A Metaanalysis of Randomized Controlled Trials.cited 19× |
| implementing nonpharmacological interventions such as light therapy | Decreases - recommend | depression | Human | persons with epilepsy and depression | Not specified | Depression in Persons With Epilepsy: Lessons From Case Review. |
| low-intensity light therapy (LT-500 lux) | Decreases - achieved response by | Hamilton Depression Rating Scale (HAMD) | Human | college students with non-seasonal subthreshold depression | 5000 lux (high-intensity) and 500 lux (low-intensity), frequency not specified. | Efficacy of light therapy for a college student sample with non-seasonal subthreshold depression: An RCT study.cited 22× |
| low-intensity light therapy (LT-500 lux) | Decreases - achieved remission by | Hamilton Depression Rating Scale (HAMD) | Human | college students with non-seasonal subthreshold depression | 5000 lux (high-intensity) and 500 lux (low-intensity), frequency not specified. | Efficacy of light therapy for a college student sample with non-seasonal subthreshold depression: An RCT study.cited 22× |
| low-intensity light therapy (LT-500 lux) | Decreases - was significantly superior to | Hamilton Depression Rating Scale (HAMD) score | Human | college students with non-seasonal subthreshold depression | 5000 lux (high-intensity) and 500 lux (low-intensity), frequency not specified. | Efficacy of light therapy for a college student sample with non-seasonal subthreshold depression: An RCT study.cited 22× |
| high-intensity light therapy (LT-5000 lux) | Decreases - achieved response by | Hamilton Depression Rating Scale (HAMD) | Human | college students with non-seasonal subthreshold depression | 5000 lux (high-intensity) and 500 lux (low-intensity), frequency not specified. | Efficacy of light therapy for a college student sample with non-seasonal subthreshold depression: An RCT study.cited 22× |
| high-intensity light therapy (LT-5000 lux) | Decreases - achieved remission by | Hamilton Depression Rating Scale (HAMD) | Human | college students with non-seasonal subthreshold depression | 5000 lux (high-intensity) and 500 lux (low-intensity), frequency not specified. | Efficacy of light therapy for a college student sample with non-seasonal subthreshold depression: An RCT study.cited 22× |
| high-intensity light therapy (LT-5000 lux) | Decreases - was significantly superior to | Hamilton Depression Rating Scale (HAMD) score | Human | college students with non-seasonal subthreshold depression | 5000 lux (high-intensity) and 500 lux (low-intensity), frequency not specified. | Efficacy of light therapy for a college student sample with non-seasonal subthreshold depression: An RCT study.cited 22× |
| blue-wavelength light therapy (BWLT) | Decreases - was significantly superior to NLT in reducing | depression | Human | patients with a history of TBI | — | Blue-wavelength light therapy for post-traumatic brain injury sleepiness, sleep disturbance, depression, and fatigue: A systematic review and network meta-analysis.cited 15× |
| blue-wavelength light therapy (BWLT) | Decreases - reduced depression at a greater extent than ALT | depression | Human | patients with a history of TBI | — | Blue-wavelength light therapy for post-traumatic brain injury sleepiness, sleep disturbance, depression, and fatigue: A systematic review and network meta-analysis.cited 15× |
| venlafaxine + bright light therapy | Decreases - evidenced significantly lower | HDRS depression scores | Human | inpatients with severe MDD | 60-minute light exposure at 7000 lux daily at 7:00 AM, combined with 150 mg venlafaxine hydrochloride daily. | Comparison of venlafaxine alone versus venlafaxine plus bright light therapy combination for severe major depressive disorder.cited 29× |
| midday bright light therapy | Decreases - may relieve | depression | Human | — | Not specified | Treating Circadian Rhythm Disruption in Bipolar Disorder.cited 49× |
| light therapy at 10,000 lux | Decreases - hints at the possibility of a reduction in depression | depression | Human | active duty service members | 10,000 lux (treatment group) and 50 lux (control group) for 90 minutes daily. | Effectiveness of light therapy for depression among active duty service members: A nonrandomized controlled pilot trial.cited 8× |
| light therapy at 10,000 lux | Decreases - showed a statistical trend for depression scores to be reduced | depression scores | Human | active duty service members deployed to an area of combat operations | 10,000 lux (treatment group) and 50 lux (control group) for 90 minutes daily. | Effectiveness of light therapy for depression among active duty service members: A nonrandomized controlled pilot trial.cited 8× |
| light therapy (combined groups) | Decreases - depression scores reduced over time | depression scores | Human | active duty service members | 10,000 lux (treatment group) and 50 lux (control group) for 90 minutes daily. | Effectiveness of light therapy for depression among active duty service members: A nonrandomized controlled pilot trial.cited 8× |
| Light Therapy (LT) | Decreases - efficacy | bipolar depression | Human | — | Not specified | Antidepressant light therapy for bipolar patients: A meta-analyses.cited 9× |
| Light Therapy (LT) | Decreases - positive effect | depression | Human | patients affected by bipolar depression | Not specified | Antidepressant light therapy for bipolar patients: A meta-analyses.cited 9× |
| Light Therapy (LT) | Decreases - significant effect | depression | Human | patients affected by bipolar depression | Not specified | Antidepressant light therapy for bipolar patients: A meta-analyses.cited 9× |
| Light therapy (LT) | Decreases - is efficacious for | bipolar depression | Human | patients with bipolar disorder (BD) | Not specified | Rate of switch from bipolar depression into mania after morning light therapy: A historical review.cited 23× |
| light therapy | No effect - did not predict change in depression | depression | Human | adults with Major Depression, Recurrent with Seasonal Pattern | Not specified | Personality Pathology in Winter Depression: Prevalence and Treatment Trajectories in Cognitive-Behavioral Therapy and Light Therapy.cited 2× |
| light therapy | Increases - improves | depression | Human | patients with Parkinson's disease | Not specified | Sleep-wake disturbances in Parkinson's disease: current evidence regarding diagnostic and therapeutic decisions.cited 20× |
| light therapy | Decreases - alleviate | depression | Human | patients with AD | Not Assessed | The effect of light therapy on sleep disorders and psychobehavioral symptoms in patients with Alzheimer's disease: A meta-analysis.cited 12× |
| light therapy | Decreases - has been shown to be an effective antidepressant | depression | Human | — | Bright white-yellowish light or dim green light for half an hour every morning. | Light therapy for better mood and insulin sensitivity in patients with major depression and type 2 diabetes: a randomised, double-blind, parallel-arm trial.cited 21× |
| light therapy | Decreases - was associated with a significant improvement in | depression | Human | cancer patients | Light intensities ranged from 417.9 to 12,000 lux (specific dosage not quantified) | Effect of Light Therapy on Cancer-Related Fatigue: A Systematic Review and Meta-Analysis.cited 18× |
| Light therapy (LT) | Decreases - showed significant optimization | depression | Human | patients with idiopathic PD | Not specified | Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Disease: A Meta-Analysis.cited 9× |
| light-therapy | Decreases - antidepressant efficacy | depression | Human | depressed patients | Not specified | Circadian rhythms and treatment implications in depression.cited 94× |
| light therapy | Decreases - antidepressant effect | depression | Human | — | Not specified | Perspectives in affective disorders: Clocks and sleep.cited 63× |
| light therapy | Decreases - might be a promising treatment for | depression | Human | a subgroup of highly insulin-resistant individuals with type 2 diabetes | 10,000 lux daily. | Effects of Light Therapy on Mood and Insulin Sensitivity in Patients With Type 2 Diabetes and Depression: Results From a Randomized Placebo-Controlled Trial.cited 30× |
| light therapy | Decreases - has shown a promising antidepressant effect | depression | Human | — | Not specified | Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study.cited 2× |
| Light therapy (LT) | Decreases - may alleviate | depression | Human | patients with ND | — | Light therapy: a new option for neurodegenerative diseases.cited 19× |
| light therapy | Decreases - reduced | depression | Human | people living with dementia | Not specified | Effectiveness of non-pharmacological interventions for sleep disturbances in people living with dementia: A systematic review and meta-analysis.cited 5× |
| light therapy | No effect - appeared to be more effective in terms of alleviating sleep disturbances, rather than reducing | depression | Human | people with dementia | Not available | The Effects of Light Therapy on Sleep, Agitation and Depression in People With Dementia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.cited 9× |
| light therapy | Decreases - was more effective than the placebo group | depression | Human | women during pregnancy and the postnatal period | Not specified | The effects of light therapy on depression and sleep in women during pregnancy or the postpartum period: A systematic review and meta-analysis.cited 8× |
| light therapy | Decreases - could be considered an effective treatment | depression | Human | women during pregnancy and the postnatal period | Not specified | The effects of light therapy on depression and sleep in women during pregnancy or the postpartum period: A systematic review and meta-analysis.cited 8× |
| light therapy | Decreases - showed small-to-medium effect on reducing | depression | Human | people living with dementia (PLWD) | Not specified | The Effects of Light Therapy on Sleep, Depression, Neuropsychiatric Behaviors, and Cognition Among People Living With Dementia: A Meta-Analysis of Randomized Controlled Trials.cited 4× |
| light therapy | Decreases - trend towards a reduction | depression (DASS-21) | Human | hemodialysis patients | 30 minutes of light therapy three times a week. | [LUMIDIAL: feasibility of light therapy in hemodialysis, pilot study and real-life experience]. |
| light therapy | Decreases - effectiveness in treating | depression | Human | — | Not specified | Light-sensitive circuits related to emotional processing underlie the antidepressant neural targets of light therapy.cited 9× |
| light therapy (LT) | No effect - discrepant results | depression | Human | patients with PTSD | Not specified | Light Therapy in Post-Traumatic Stress Disorder: A Systematic Review of Interventional Studies. |
| light therapy | Decreases - alleviates | depression | Human | — | Not specified | Light therapy for sleep disturbance comorbid depression in relation to neural circuits and interactive hormones-A systematic review.cited 1× |
| light therapy | Decreases - alleviates | sleep disturbance comorbid depression (SDCD) | Human | — | Not specified | Light therapy for sleep disturbance comorbid depression in relation to neural circuits and interactive hormones-A systematic review.cited 1× |
| light therapy | No effect - does not prevent recurrence | depression in subsequent seasons | Human | patients with seasonal affective disorder | Not specified for light therapy; MBCT was administered individually between May and June 2011. | Mindfulness-based cognitive therapy for seasonal affective disorder: a pilot study.cited 8× |
| light therapy | No effect - unrelated to | depression recurrence | Human | SAD patients | Not mentioned | A measure of cognitions specific to seasonal depression: Development and validation of the Seasonal Beliefs Questionnaire.cited 9× |
| light therapy (LT) | No effect - was associated with depression recurrences | depression recurrences | Human | patients with winter seasonal affective disorder (SAD) | Not specified in the abstract. | Elucidating treatment targets and mediators within a confirmatory efficacy trial: study protocol for a randomized controlled trial of cognitive-behavioral therapy vs. light therapy for winter depression. |
| light therapy (LT) | No effect - did not prescriptively predict higher likelihood of depression remission | depression remission | Human | adults diagnosed with Major Depression, Recurrent with Seasonal Pattern | — | Body mass index and atypical balance as predictors of winter depression remission in cognitive-behavioral therapy and light therapy.cited 3× |
| light therapy (LT) | Decreases - probability of remission was lower | depression remission | Human | adults diagnosed with Major Depression, Recurrent with Seasonal Pattern with BMI ≤ 26.1 | — | Body mass index and atypical balance as predictors of winter depression remission in cognitive-behavioral therapy and light therapy.cited 3× |
| light therapy (LT) | Decreases - probability of remission was lower | depression remission | Human | adults diagnosed with Major Depression, Recurrent with Seasonal Pattern with atypical balance ≤ 40.3% | — | Body mass index and atypical balance as predictors of winter depression remission in cognitive-behavioral therapy and light therapy.cited 3× |
| light therapy | Decreases - had a significant reduction | depression score | Human | experimental group | 10000-lux light box for 30 minutes in the morning, three times a week. | The effects of light therapy on depression and sleep disruption in older adults in a long-term care facility.cited 15× |
| light therapy | No effect - no significant difference | depression score | Human | experimental group compared to control group | 10000-lux light box for 30 minutes in the morning, three times a week. | The effects of light therapy on depression and sleep disruption in older adults in a long-term care facility.cited 15× |
| light therapy | Decreases - decreased | mean depression score | Human | older adults residing in a long-term care facility | 10000-lux light box for 30 minutes in the morning, three times a week. | The effects of light therapy on depression and sleep disruption in older adults in a long-term care facility.cited 15× |
| light therapy | Decreases - more appetitive symptoms at baseline predicted more of a decrease | depression scores | Human | individuals in the light therapy group | Not specified in the abstract. | Appetitive Symptoms Differentially Predict Treatment Response to Fluoxetine, Light, and Placebo in Nonseasonal Major Depression.cited 5× |
| light therapy | Decreases - improved significantly | Depression severity measured with the BDI-II | Human | 177 adults with a current episode of major depression that was recurrent with a seasonal pattern | 10,000-lux cool-white fluorescent light, initiated at 30 minutes each morning and adjusted based on response and side effects. | Randomized Trial of Cognitive-Behavioral Therapy Versus Light Therapy for Seasonal Affective Disorder: Acute Outcomes.cited 31× |
| light therapy | Decreases - improved significantly | Depression severity measured with the SIGH-SAD | Human | 177 adults with a current episode of major depression that was recurrent with a seasonal pattern | 10,000-lux cool-white fluorescent light, initiated at 30 minutes each morning and adjusted based on response and side effects. | Randomized Trial of Cognitive-Behavioral Therapy Versus Light Therapy for Seasonal Affective Disorder: Acute Outcomes.cited 31× |
| light therapy (LT) | Decreases - can reduce | depression symptoms | Human | — | Not specified | Circadian light therapy and light dose for depressed young people: a systematic review and meta-analysis. |
| light therapy | Decreases - comparably efficacious | depression symptoms | Human | Currently depressed adults with Major Depression, Recurrent with Seasonal Pattern | Not specified | Change in Seasonal Beliefs Mediates the Durability Advantage of Cognitive-Behavioral Therapy Over Light Therapy for Winter Depression.cited 4× |
| light therapy | Decreases - has a positive effect on | geriatric non-seasonal depression | Human | older patients with non-seasonal depression | Not specified | Light therapy for older patients with non-seasonal depression: A systematic review and meta-analysis.cited 34× |
| light therapy | Decreases - was associated with a significant improvement in | Hamilton Depression Rating Scale score | Human | patients with bipolar disorder | Not specified in the abstract. | Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials.cited 35× |
| adjunctive light therapy | Decreases - reduces | symptoms of bipolar depression | Human | patients with bipolar disorder | Not specified in the abstract. | Light Therapy for Patients With Bipolar Depression: Systematic Review and Meta-Analysis of Randomized Controlled Trials.cited 35× |
| Light therapy | No effect - might also be beneficial | hypersomnolence in depression | Human | these populations | Not specified | Diagnosing and treating hypersomnolence in depression.cited 2× |
| Light therapy (LT) | Decreases - can be used as a first-line monotherapy | moderate to severe depression of all subtypes | Human | — | Not specified | Biological rhythms and chronotherapeutics in depression.cited 45× |
| light therapy (LT) | Increases - had more severe depressive symptoms | next winter depression outcomes | Human | SAD patients with baseline dysfunctional attitudes and negative automatic thoughts at or above the sample mean | Not specified | Cognitive predictors and moderators of winter depression treatment outcomes in cognitive-behavioral therapy vs. light therapy.cited 7× |
| light therapy (LT) | Increases - did not fare as well | subsequent winter depression | Human | SAD patients with extremely rigid cognitions | Not specified | Cognitive predictors and moderators of winter depression treatment outcomes in cognitive-behavioral therapy vs. light therapy.cited 7× |
| light therapy | Decreases - increasingly been used in relieving | non-seasonal depression | Human | — | Not specified | A critical overview of systematic reviews and meta-analyses of light therapy for non-seasonal depression.cited 12× |
| light therapy | Decreases - is effective as a non-pharmacological intervention for the treatment of | non-seasonal depression | Human | — | Not specified | A critical overview of systematic reviews and meta-analyses of light therapy for non-seasonal depression.cited 12× |
| light therapy | No effect - remains unclear | non-seasonal depression | Human | — | Not specified | Light therapy in non-seasonal depression: An update meta-analysis.cited 61× |
| light therapy | Decreases - was significantly more effective than comparative treatments | non-seasonal depression | Human | 1120 participants | Not specified | Light therapy in non-seasonal depression: An update meta-analysis.cited 61× |
| light therapy | Decreases - ameliorating symptoms | seasonal affective disorder and depression | Human | adults | Not applicable (study used light therapy, not DIM). | Morning light therapy for juvenile depression and severe mood dysregulation: study protocol for a randomized controlled trial.cited 11× |
| morning bright-light therapy | No effect - effects | juvenile depression and severe mood dysregulation | Human | patients with depression, aged between 12 and 18 years | Not applicable (study used light therapy, not DIM). | Morning light therapy for juvenile depression and severe mood dysregulation: study protocol for a randomized controlled trial.cited 11× |
| light therapy | Decreases - can be an effective therapy | seasonal and non-seasonal major depression | Human | — | Not specified | The Antidepressant Effect of Light Therapy from Retinal Projections.cited 18× |
| light therapy | No effect - supports use | seasonal depression | Human | — | Not specified | Getting depression clinical practice guidelines right: time for change?cited 14× |
| light therapy | Decreases - could be effective | season depression | Human | children and young people up to the age of 25 years | Not available | Strategies not accompanied by a mental health professional to address anxiety and depression in children and young people: a scoping review of range and a systematic review of effectiveness.cited 24× |
| light therapy | No effect - nonstandard alternatives | treating depression | Human | — | Not mentioned | Therapeutic armamentarium for treating depression.cited 9× |
| light therapy | No effect - have evidence | treatment of depression | Human | — | Not specified | Wait-there's evidence for that? Integrative medicine treatments for major depressive disorder. |
| light therapy | No effect - have evidence | treatment of depression | Human | — | Not specified | Wait-there's evidence for that? Integrative medicine treatments for major depressive disorder. |
| light therapy | No effect - promising but limited in effectiveness | treatment-resistant bipolar depression | Human | patients with bipolar disorder | Not specified | Evidence-based options for treatment-resistant adult bipolar disorder patients.cited 44× |
| light therapy | No effect - Utilize multi-treatment modules such as combination of psychotherapy and pharmacotherapy in conjunction with brain stimulation therapy | Treatment-Resistant Depression | Human | patients with Major Depressive Disorder | Not mentioned | Optimized Treatment Strategy for Depressive Disorder.cited 14× |
| Bright Light Therapy (BLT) group (10,000 lx) | Decreases - significantly decreased | Depression symptom scores | Human | college students with subthreshold depression (SD) | BLT (10,000 lx) and DLT (200 lx); frequency not specified. | Efficacy evaluation and facial expressions biomarker of light therapy in youths with subthreshold depression: A randomized control trial study. |
| Dim Light Therapy (DLT) group (200 lx) | Decreases - significantly decreased | Depression symptom scores | Human | college students with subthreshold depression (SD) | BLT (10,000 lx) and DLT (200 lx); frequency not specified. | Efficacy evaluation and facial expressions biomarker of light therapy in youths with subthreshold depression: A randomized control trial study. |
| adjunctive bright light therapy with gradual timing advance | Increases - is an effective adjunctive treatment | remission of depression | Human | patients with non-seasonal unipolar depression and evening-chronotype | Not specified (only mentions "dim red light" without dosage details). | Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype - A randomized controlled trial.cited 23× |
| 5-week adjunctive bright light therapy with a gradual advance protocol | Increases - predicted a higher likelihood | depression remission | Human | patients with unipolar depression and evening preference | — | Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference.cited 16× |
| 5-week adjunctive bright light therapy with a gradual advance protocol | Increases - predicted a 2-fold increase | remission of depression | Human | patients with depression | — | Change in circadian preference predicts sustained treatment outcomes in patients with unipolar depression and evening preference.cited 16× |
| other somatic treatments including brain stimulation techniques and light therapy | No effect - showed benefit | postpartum depression | Human | — | Not available | Understanding and treating postpartum depression: a narrative review.cited 2× |
| adjunctive bright light therapy at midday | Decreases - significantly lower depression scores | depression scores | Human | depressed adults with bipolar I or II disorder | 7,000-lux bright white light (intervention) vs. 50-lux dim red light (placebo). | Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial.cited 103× |
| bright light therapy (BLT) augmentation | No effect - assessed | 17-item Hamilton Depression Rating Scale | Human | outpatients who had received stable dosages and various regimens of antidepressive agents for 4 weeks before enrollment | Not specified | Adjunctive Bright Light Therapy for Non-Seasonal Major Depressive Disorder: A Randomized Controlled Trial.cited 6× |
| bright light therapy (BLT) augmentation | No effect - assessed | Montgomery-Asberg Depression Rating Scale | Human | outpatients who had received stable dosages and various regimens of antidepressive agents for 4 weeks before enrollment | Not specified | Adjunctive Bright Light Therapy for Non-Seasonal Major Depressive Disorder: A Randomized Controlled Trial.cited 6× |
| morning bright light therapy | No effect - had no impact on this change | Beck Depression Inventory-II (BDI-II) score | Human | adolescent inpatients with moderate or severe major depressive disorder | 10,000 lux (bright light therapy) or 100 lux (placebo red light), up to 20 sessions. | Bright Light Therapy as Add-On to Inpatient Treatment in Youth With Moderate to Severe Depression: A Randomized Clinical Trial.cited 3× |
| 6 weeks of daily 30-minute sessions of morning blue light therapy | Decreases - moderate to large improvements were observed | Beck Depression Inventory II | Human | Adults aged 18 to 45 years with a mild traumatic brain injury within the past 18 months | 30-minute daily sessions. | Daily Morning Blue Light Therapy Improves Daytime Sleepiness, Sleep Quality, and Quality of Life Following a Mild Traumatic Brain Injury.cited 28× |
| high-intensity blue light therapy | No effect - There was also no significant treatment effect observed for | self-reported depression | Human | patients with TBI who self-reported fatigue and/or sleep disturbance | 45 minutes per morning of blue light (λmax = 465 nm, 84.8 µW/cm², 39.5 lux, 1.74 × 10¹⁴ photons/cm²/s) or yellow light (λmax = 574 nm, 18.5 µW/cm², 68 lux, 1.21 × 10¹² photons/cm²/s). | Randomized controlled trial of light therapy for fatigue following traumatic brain injury.cited 83× |
| Adjunct Bright Light Therapy (BLT) | Decreases - has shown efficacy in treating depression | depression | Human | — | Not specified | Evaluating the impact of adjunct bright light therapy on subjective sleep quality in major depressive disorder.cited 4× |