5
2
↑5
↓2
—0
Evidence suggests Nicotine mayincreaseStress.
7 studies (7 claims)
Emerging evidence
Typical effective dose 2 (2–2) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| nicotine | Decreases - mitigating | oxidative stress | Animal | — | Not specified | [Effects of nicotine exposure on endogenous metabolites in mouse brain based on metabolomics and mass spectrometry imaging]. |
| nicotine | Increases - induces hormetic dose responses | resilience to inflammatory stress | HumanMolecular | bone marrow stem cells (BMSCs) | Not specified | Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress.cited 20× |
| nicotine | Increases - increased | TAA-induced oxidative stress | HumanAnimalMolecular | mice | Nicotine (50 or 100 μg/mL) administered daily via gastrogavage. | Detrimental effects of nicotine on thioacetamide-induced liver injury in mice. |
| intervention including nicotine replacement therapy, brief individual counseling, and a 2-week JITAI | Decreases - showed significant decreases | perceived stress | Human | participants motivated to quit smoking | Not specified | Proximal Effects of a Just-in-Time Adaptive Intervention for Smoking Cessation With Wearable Sensors: Microrandomized Trial. |
| nicotine and uric acid | Increases - produced | oxidative stress | Animal | rats | 70 mg kg(-1)day(-1), orally | Benfotiamine attenuates nicotine and uric acid-induced vascular endothelial dysfunction in the rat.cited 31× |
| 15-day repeated nicotine treatment at a daily dose of 2 mg/kg body weight | Increases - significantly increased | oxidative stress | Animal | adolescent male rats | 2 mg/kg body weight daily. | Repeated exposure to high-dose nicotine induces prefrontal gray matter atrophy in adolescent male rats. |
| nicotine administration | Increases - led to elevated levels | IL-6, IL-1β, MDA, TOS, and oxidative stress index | Animal | Male rats | 500 mg/kg/day | Dexpanthenol exhibits antiapoptotic and anti-inflammatory effects against nicotine-induced liver damage by modulating Bax/Bcl-xL, Caspase-3/9, and Akt/NF-κB pathways.cited 10× |