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Evidence suggests Nicotine maydecreasePain.
4 studies (5 claims)
Emerging evidence
Typical effective dose 21 (21–21) mgacross 1 dosed study
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| nicotine | Decreases - reduce | post-surgical pain | Human | clinical and preclinical studies | 20 g of lecithin before surgery. | Oral choline supplementation for postoperative pain.cited 7× |
| a combination of caffeine and nicotine | Increases - increase | pain thresholds | Animal | male C57BL/6J mice | Caffeine (20 mg/kg) combined with nicotine (0.1 mg/kg). | The Effect of a Caffeine and Nicotine Combination on Nicotine Withdrawal Syndrome in Mice. |
| high dose (21 mg/24 h) transdermal nicotine (TDN) patch | Decreases - would reduce | postoperative pain and opioid requirements | Human | abstinent tobacco smokers undergoing single-level spinal fusion | 21 mg/24 h transdermal nicotine patch. | Effect of Nicotine Replacement Therapy on Perioperative Pain Management and Opioid Requirement in Abstinent Tobacco Smokers Undergoing Spinal Fusion: A Double-blind Randomized Controlled Trial.cited 1× |
| nicotine treatment | Decreases - were lower | postoperative pain scores at rest and on movement | Human | abstinent tobacco smokers undergoing single-level spinal fusion | 21 mg/24 h transdermal nicotine patch. | Effect of Nicotine Replacement Therapy on Perioperative Pain Management and Opioid Requirement in Abstinent Tobacco Smokers Undergoing Spinal Fusion: A Double-blind Randomized Controlled Trial.cited 1× |