4
3
1
↑4
↓3
—1
Evidence suggests Nicotine mayincreaseLung function.
8 studies (8 claims)
Emerging evidence
Typical effective dose 2 (1.05–3.5) mgacross 3 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| nicotine supplementation | Increases - increasing | cognitive function | Human | archery athletes | 2 mg nicotine gum (single dose). | Nicotine supplementation enhances simulated game performance of archery athletes.cited 5× |
| nicotine | Increases - significantly alter | biological processes related to synaptic function | Animal | mice | Not specified | Comparative effects of arecoline, caffeine, and nicotine on transcription level in the nucleus accumbens of mice.cited 1× |
| nicotine | Increases - significantly enhances | platelet function | HumanMolecular | — | Not specified | Nicotine's impact on platelet function: insights into hemostasis mechanisms.cited 1× |
| Maternal smoking during pregnancy (MSDP), driven by nicotine crossing the placenta | Decreases - causes lifelong decreases | offspring pulmonary function | Human | offspring | Not specified in the abstract. | Vitamin C supplementation improves placental function and alters placental gene expression in smokers.cited 3× |
| nicotine-ethanol abstinence | Decreases - associated with reduced | cholinergic and neurotrophic function | Animal | male Wistar rats | Not specified | Oral administration of coenzyme Q10 ameliorates memory impairment induced by nicotine-ethanol abstinence through restoration of biochemical changes in male rat hippocampal tissues.cited 3× |
| single doses of nicotine | Increases - may be able to enhance | relevant aspects of cognitive function and/or alertness | Human | — | — | Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance.cited 22× |
| chronic nicotine administration | No effect - showed no significant differences | cognitive function | Animal | 6-month-old cohort (DKO and WT mice) | 100 μg/ml oral nicotine treatment | Age- and Genotype-Dependent Effects of Chronic Nicotine on Presenilin1/2 Double Knockout Mice: From Behavior to Molecular Pathways. |
| nicotine vape aerosol | Decreases - significantly decreased | Myocardial function after infarction | Animal | Mice | 5 mg/mL nicotine in flavored vape juice. | Myocardial Infarction Injury Is Exacerbated by Nicotine in Vape Aerosol Exposure. |