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Evidence suggests Nicotine maydecreaseAnxiety.
3 studies (3 claims)
Emerging evidence
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| nicotine | Decreases - anxiolytic effects | anxiety | Animal | — | Not specified | [Effects of nicotine exposure on endogenous metabolites in mouse brain based on metabolomics and mass spectrometry imaging]. |
| a combination of caffeine and nicotine | Decreases - reduce | anxiety | Animal | male C57BL/6J mice | Caffeine (20 mg/kg) combined with nicotine (0.1 mg/kg). | The Effect of a Caffeine and Nicotine Combination on Nicotine Withdrawal Syndrome in Mice. |
| nicotine administration | Increases - resulted in | anxiety | Animal | rat model | Dose-dependent effects evaluated (specific amounts not stated) | Preventive effects of crocin, a natural compound from saffron, against nicotine‑induced oxidative stress and neurobehavioral disturbances.cited 2× |