1
23
8
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Evidence suggests Melatonin maydecreaseToxicity.
31 studies (32 claims)
Moderate consensus
Typical effective dose 6 (4.5–13) mgacross 3 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin supplementation therapy | Decreases - seems to be a suitable therapeutic agent to eliminate the adverse effects | arsenic toxicity | Human | — | Not specified | Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity.cited 14× |
| melatonin | Decreases - attenuate acute and long-term drug toxicity | acute and long-term drug toxicity | Human | cancer patients | Not specified | Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.cited 310× |
| melatonin | No effect - prevented AMPH-induced toxicity in the hippocampus | AMPH-induced toxicity in the hippocampus | Animal | postnatal rats | — | Neuroprotective effects of melatonin on amphetamine-induced dopaminergic fiber degeneration in the hippocampus of postnatal rats. |
| melatonin | Decreases - potential therapeutic value | cardiovascular toxicity | Human | — | Not specified. | Melatonin attenuates chemical-induced cardiotoxicity.cited 6× |
| melatonin | Decreases - beneficial impact | Cd-induced male reproductive toxicity | Human | — | Not mentioned | Cadmium as a male reproductive toxicant and natural and non-natural ways to tackle it: a review. |
| melatonin | Decreases - beneficial impact | Cd-induced male reproductive toxicity | Human | — | Not mentioned | Cadmium as a male reproductive toxicant and natural and non-natural ways to tackle it: a review. |
| melatonin | Decreases - has shown to induce modulation of chemotherapy toxicity | chemotherapy toxicity | Human | — | Not specified | The Role of Melatonin in Colorectal Cancer.cited 15× |
| melatonin | Decreases - protective mechanisms | heavy metal-induced reproductive toxicity | Human | — | — | Heavy metal and metalloid - induced reproductive toxicity.cited 61× |
| Melatonin | Decreases - counteracts several pathophysiologic steps and displays significant beneficial effects | hyperglycemia-induced cellular toxicity | Human | — | Not specified | Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state.cited 32× |
| melatonin | Decreases - can reduce | lead toxicity | AnimalMolecular | in vivo and in vitro | — | Melatonin reduces lead levels in blood, brain and bone and increases lead excretion in rats subjected to subacute lead treatment. |
| Melatonin | Decreases - alleviating | normal tissue toxicity | Human | — | — | Modulation of the immune system by melatonin; implications for cancer therapy.cited 33× |
| melatonin | Decreases - document the very low toxicity | toxicity | Human | — | Not specified | Clinical uses of melatonin: evaluation of human trials.cited 219× |
| melatonin | No effect - no significant differences | toxicity | Human | cachectic patients with advanced cancer | 20 mg at night | Effects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.cited 72× |
| melatonin | No effect - do not show toxicity | toxicity | Human | humans | Not specified. | An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders.cited 18× |
| melatonin | Decreases - registered | toxicity | HumanMolecular | cancer patients | Not specified | Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks.cited 47× |
| melatonin | Decreases - has very low toxicity | toxicity | Human | — | Not specified | Melatonin and male reproductive health: relevance of darkness and antioxidant properties.cited 32× |
| melatonin | Decreases - documented low toxicity | toxicity | Human | — | Not specified | Melatonin and breast cancer: Evidences from preclinical and human studies.cited 80× |
| melatonin | Decreases - has low toxicity | toxicity | HumanAnimal | — | Not specified in the abstract. | Melatonin as a Therapy for Traumatic Brain Injury: A Review of Published Evidence.cited 37× |
| melatonin | No effect - did not demonstrate toxicity | toxicity | Human | — | 0.5–3 mg (children), 3–5 mg (adolescents), 1–5 mg (adults), 1–6 mg (elderly). | Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review.cited 8× |
| melatonin | No effect - no significant toxicity or treatment-related side effects with long-term therapy have been reported | toxicity and side effects | Human | newborns | Not specified | Oxidative Stress-Mediated Damage in Newborns with Necrotizing Enterocolitis: A Possible Role of Melatonin.cited 39× |
| melatonin | Decreases - showed | very low toxicity | Human | clinical practice | Not specified | Melatonin in experimental seizures and epilepsy.cited 73× |
| melatonin (MEL) and/or L-carnitine (L-CAR) | Decreases - significantly protected hepatocytes against toxicity | hepatocyte toxicity | AnimalMolecular | isolated rat hepatocytes | — | Protective effects of melatonin and L-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes. |
| melatonin treatment | Decreases - only partially reversed | glutamate toxicity | Molecular | VSC4.1 motoneuron cell line | — | Overexpression of melatonin membrane receptors increases calcium-binding proteins and protects VSC4.1 motoneurons from glutamate toxicity through multiple mechanisms. |
| melatonin with adenosine at a ratio of 1:4, stabilized with 30% of glycine (MLT-DBM) | Increases - positive therapeutic responses and a total absence of toxicity | therapeutic response and toxicity | Human | many patients with various indications | Melatonin with adenosine at a 1:4 ratio, stabilized with 30% glycine (MLT-DBM). | Melatonin with adenosine solubilized in water and stabilized with glycine for oncological treatment - technical preparation, effectivity and clinical findings.cited 3× |
| melatonin supplementation | No effect - was well tolerated | toxicity | Human | — | 3 mg oral melatonin daily | A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers.cited 29× |
| long-term melatonin therapy | No effect - No significant toxicity or treatment-related side effects | toxicity or side effects | Human | children and adults | Not specified | Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period.cited 53× |
| Melatonin and Ginseng | Decreases - reduce | testicular toxicity induced by Cd | Animal | rats | 100 mg/kg (oral gavage). | Effect of Melatonin and Ginseng on rat testis and sperm quality against cadmium toxicity via inhibiting oxidative stress and autophagy pathways. |