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Evidence suggests Melatonin maydecreaseToxicity.

10 studies (10 claims)

Typical dose 13 mg

Exact normalized-entity scope. Exact scope. Claims must match the selected normalized intervention and endpoint IDs; signal links are not expanded. Direction describes the stored endpoint phrase and is not a benefit/harm judgement.
8 of 10
InterventionDirectionEndpointTypePopulationDosageTitle
melatoninNo effect - do not show toxicitytoxicity
Human
humansNot specified.An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders.cited 18×
melatoninDecreases - document the very low toxicitytoxicity
Human
Not specifiedClinical uses of melatonin: evaluation of human trials.cited 219×
melatoninNo effect - no significant differencestoxicity
Human
cachectic patients with advanced cancer20 mg at nightEffects of melatonin on appetite and other symptoms in patients with advanced cancer and cachexia: a double-blind placebo-controlled trial.cited 72×
melatoninDecreases - registeredtoxicity
HumanMolecular
cancer patientsNot specifiedUpdate on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks.cited 47×
melatoninDecreases - has very low toxicitytoxicity
Human
Not specifiedMelatonin and male reproductive health: relevance of darkness and antioxidant properties.cited 32×
melatoninDecreases - documented low toxicitytoxicity
Human
Not specifiedMelatonin and breast cancer: Evidences from preclinical and human studies.cited 80×
melatoninDecreases - has low toxicitytoxicity
HumanAnimal
Not specified in the abstract.Melatonin as a Therapy for Traumatic Brain Injury: A Review of Published Evidence.cited 37×
melatoninNo effect - did not demonstrate toxicitytoxicity
Human
0.5–3 mg (children), 3–5 mg (adolescents), 1–5 mg (adults), 1–6 mg (elderly).Regulatory aspects and evidences of melatonin use for sleep disorders and insomnia: an integrative review.cited 8×