4
1
↑4
↓1
—0
Evidence suggests Melatonin mayincreaseTotal sleep time.
5 studies (5 claims)
Emerging evidence
Typical effective dose 5 (3–8.5) mgacross 3 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin | Increases - significantly improved | total sleep time | Human | children (<18 years) with neurodevelopmental disorders | Not specified | Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.cited 62× |
| melatonin | Increases - increased | total sleep time | Human | children aged 3 years to 15 years 8 months with neurodevelopmental disorders and a severe sleep problem | Started at 0.5 mg, increased to 2 mg, 6 mg, or 12 mg depending on response, administered 45 minutes before bedtime. | Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial.cited 120× |
| novel pediatric appropriate, prolonged release melatonin minitablets | Increases - slept on average longer at night | total sleep time | Human | children and adolescents with autism spectrum disorder (ASD), with or without attention-deficit/hyperactivity disorder (ADHD) comorbidity, and neurogenetic disorders (NGD) | 2 mg escalated to 5 mg. | Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder.cited 147× |
| melatonin therapy | Increases - prolonged | total sleep time | Human | patients with dementia | Not specified | Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials.cited 77× |
| simulated icu noise and light | Decreases - shorter | total sleep time | Human | healthy subjects | 1 mg oral melatonin administered at 21:00. | Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?cited 62× |