25
198
8
↑25
↓198
—8
Evidence suggests Melatonin maydecreaseStress.
206 studies (231 claims)
Strong consensus
Typical effective dose 12 (5–25) mgacross 21 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin administration | No effect - modulating | oxidative stress | Human | — | 5 mg melatonin tablets twice daily. | Effects of melatonin supplementation on metabolic parameters, oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: study protocol for a double-blind, randomized controlled trial.cited 1× |
| melatonin supplementation | No effect - primary outcome is changes in | oxidative stress and inflammatory biomarkers | Human | — | 5 mg melatonin tablets twice daily. | Effects of melatonin supplementation on metabolic parameters, oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: study protocol for a double-blind, randomized controlled trial.cited 1× |
| melatonin administration | Decreases - reducing | oxidative stress | Human | — | Not specified | From Implantation to Birth: Insight into Molecular Melatonin Functions. |
| melatonin administration | Decreases - reducing | oxidative stress | Human | — | Not specified | From Implantation to Birth: Insight into Molecular Melatonin Functions. |
| 150 μM exogenous melatonin applied three times at different fruit development stages | No effect - may be a sustainable and useful approach | management of transient moisture stress | Animal | mango trees | 20, 50, 100, and 150 μM melatonin applied three times at different fruit development stages. | Exogenous Melatonin Enhances Moisture Stress Tolerance in Mango (Mangifera indica L.) through Alleviating Oxidative Damages.cited 1× |
| higher dose (25 mg) melatonin | Decreases - target | brain oxidative stress | Human | older adults with mild cognitive impairment (MCI) | 25 mg oral melatonin nightly. | Feasibility of 3-month melatonin supplementation for brain oxidative stress and sleep in mild cognitive impairment: protocol for a randomised, placebo-controlled study.cited 7× |
| melatonin | No effect - effect on | brain oxidative stress | Human | individuals with MCI | 25 mg oral melatonin nightly. | Feasibility of 3-month melatonin supplementation for brain oxidative stress and sleep in mild cognitive impairment: protocol for a randomised, placebo-controlled study.cited 7× |
| Long-term melatonin administration | Increases - accelerated | testicular recovery after heat stress | AnimalMolecular | — | 50 mg/kg for 5 days (pretreatment) | Prolonged melatonin treatment promote testicular recovery by enhancing RAC1-mediated apoptotic cell clearance and cell junction-dependent spermatogensis after heat stress.cited 13× |
| melatonin | Increases - restored | gap junctions and tight junctions after heat stress | AnimalMolecular | in vitro studies | 50 mg/kg for 5 days (pretreatment) | Prolonged melatonin treatment promote testicular recovery by enhancing RAC1-mediated apoptotic cell clearance and cell junction-dependent spermatogensis after heat stress.cited 13× |
| melatonin pretreatment (50 mg/kg for 5 days) | No effect - did not alleviate | heat stress-induced germ cell loss and disrupted testicular histomorphology | AnimalMolecular | 8-week-old male CD-1 mice | 50 mg/kg for 5 days (pretreatment) | Prolonged melatonin treatment promote testicular recovery by enhancing RAC1-mediated apoptotic cell clearance and cell junction-dependent spermatogensis after heat stress.cited 13× |
| melatonin | Decreases - plays a pivotal role in preventing | age-related oxidative stress | Human | — | Not specified | Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?cited 18× |
| melatonin | Increases - enhancing | anti-stress abilities | Human | different types of disc cells | Not specified | The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review.cited 48× |
| melatonin | Decreases - blocks | apoptosis induced by endoplasmic reticulum stress and caspase activation | Animal | rats and mice | — | A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies.cited 9× |
| melatonin | Decreases - improves | oxidative stress | Animal | rats and mice | — | A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies.cited 9× |
| melatonin | Decreases - protected against | brain oxidative stress | Animal | 3xTg-AD male mice aged from 6 to 12 months | Not specified | Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.cited 82× |
| melatonin | Increases - normalization of | Ca(2+) dependent and independent contraction, mitochondrial polarity, neuromuscular function and oxidative stress | Human | old animals | Not specified | Melatonin, a potential therapeutic agent for smooth muscle-related pathological conditions and aging.cited 36× |
| melatonin | Decreases - able to reduce or mitigate | cell damage associated with oxidative stress and inflammation | Human | — | Not specified | The role of melatonin in multiple sclerosis, Huntington's disease and cerebral ischemia.cited 43× |
| Melatonin | Decreases - suppresses chronic oxidative stress | chronic oxidative stress | Human | — | Not specified | Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment.cited 63× |
| melatonin | No effect - exerts a wide range of different effects | circadian rhythm regulation, thermoregulation, sleep induction, antioxidant, immunomodulatory, and anti-stress ones | Human | — | Not specified | Alcohol and melatonin.cited 14× |
| Melatonin | No effect - evaluated treatments included | correcting oxidative stress parameters, enhancing exogenous antioxidant capacity, modifying electrocardiographic abnormalities, and improving heart contraction strength | Human | — | Not specified | Discovering the most impactful treatments for aluminum phosphide cardiotoxicity gleaned from systematic review of animal studies. |
| Melatonin | No effect - evaluated treatments included | correcting oxidative stress parameters, enhancing exogenous antioxidant capacity, modifying electrocardiographic abnormalities, and improving heart contraction strength | Human | — | Not specified | Discovering the most impactful treatments for aluminum phosphide cardiotoxicity gleaned from systematic review of animal studies. |
| melatonin | Decreases - proved efficient in reducing | degree of oxidative stress | Human | melatonin-treated men | Not specified | Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males.cited 73× |
| melatonin | Decreases - decreased significantly | ER Stress | HumanMolecular | HGF | Not specified | 4PBA strongly attenuates endoplasmic reticulum stress, fibrosis, and mitochondrial apoptosis markers in cyclosporine treated human gingival fibroblasts.cited 23× |
| melatonin | Decreases - shows promise in controlling | ER stress | Molecular | — | Not specified | Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review.cited 5× |
| melatonin | Decreases - alleviates the burden of | ER stress | Molecular | in most pathological contexts | Not specified | Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review.cited 5× |
| melatonin | Increases - paradoxically stimulate | ER stress | Molecular | in cancer cells | Not specified | Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review.cited 5× |
| melatonin | Decreases - reduction of | oxidative stress | Molecular | — | Not specified | Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review.cited 5× |
| melatonin | Decreases - reversed | ER stress | AnimalMolecular | young male Sprague-Dawley rats | — | Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats. |
| melatonin | Decreases - reversed | ER stress | AnimalMolecular | young rats | — | Melatonin Alleviates Liver Apoptosis in Bile Duct Ligation Young Rats. |
| melatonin | Decreases - suppresses | ER stress and intracellular calcium overload | Molecular | in vitro retinal pigment epithelium (RPE) death model | — | Melatonin protects RPE cells from necroptosis and NLRP3 activation via promoting SERCA2-related intracellular Ca |
| melatonin (MEL) | Decreases - suppressed | ER stress markers (GRP78, ATF4, ATF6, sXBP1, CHOP) | Animal | Sprague-Dawley rats | 10 mg/kg and 20 mg/kg, administered intraperitoneally | Therapeutic role of melatonin on acrylamide-induced neurotoxicity via reducing ER stress, inflammation, and apoptosis in a rat model. |
| melatonin | Decreases - decreased | ER stress markers (GRP78, ATF6, IRE1α, and PERK) | Animal | ZDF rats | — | Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats. |
| melatonin | Decreases - has beneficial effects | exercise-induced oxidative stress | Human | athletes | 100 mg/day | The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes.cited 38× |
| melatonin | Decreases - will quench free radicals | free radicals causing oxidative stress | Human | — | Not specified | "LONG COVID"-A hypothesis for understanding the biological basis and pharmacological treatment strategy.cited 77× |
| melatonin | Decreases - modulating | inflammation and oxidative stress | Human | — | Not specified | Melatonin: Evolving Physiological Understanding and Potential Therapeutic Role in Pain Medicine Including Intervertebral Disc Degeneration.cited 1× |
| Melatonin | Decreases - decreasing | inflammatory and oxidative stress levels in testicular tissue | Animal | male dairy goats under HS | Not specified | Melatonin alleviates heat stress-induced spermatogenesis dysfunction in male dairy goats by regulating arachidonic acid metabolism mediated by remodeling the gut microbiota.cited 1× |
| melatonin | Decreases - therapeutic interventions specifically aimed at reducing | levels of inflammation and oxidative stress | Human | — | Not specified | The role of high-density lipoprotein cholesterol, apolipoprotein A and paraoxonase-1 in the pathophysiology of neuroprogressive disorders.cited 39× |
| melatonin | Decreases - has antioxidant, anti-inflammatory, and neuroprotective effects | lipid peroxidation and oxidative stress during brain ischemia | Human | — | Not specified | Blood-brain barrier dysfunction in hemorrhagic transformation: a therapeutic opportunity for nanoparticles and melatonin.cited 7× |
| melatonin | Decreases - protect | melanocytes from UVB-induced DNA damage and oxidative stress | Human | melanocytes | — | Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways. |
| melatonin metabolites | Decreases - protect | melanocytes from UVB-induced DNA damage and oxidative stress | Human | melanocytes | — | Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways. |
| melatonin | Decreases - reduces | oxidative and endoplasmic reticulum stress | Human | diabetic patients | Not specified | New insights into the role of melatonin in diabetic cardiomyopathy.cited 14× |
| melatonin | Decreases - potent activity against | oxidative and nitrosative stress-induced damage | Human | nervous system | Not specified | Role of melatonin supplementation in neurodegenerative disorders.cited 39× |
| melatonin | Decreases - prevents | oxidative stress (OS) | AnimalMolecular | porcine in vitro fertilization -derived embryos | — | Melatonin enhances porcine embryo development via the Nrf2/ARE signaling pathway. |
| Melatonin | Decreases - reduced | oxidative stress | Human | patients with hypertension | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| Melatonin | Decreases - reduced | oxidative stress | Human | patients with metabolic syndrome | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| Melatonin | Decreases - reduced | oxidative stress | Human | patients with coronary artery disease | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| Melatonin | Decreases - reduced | oxidative stress | Human | patients with heart failure | — | Expression of Melatonin Receptor 1 in Rat Mesenteric Artery and Perivascular Adipose Tissue and Vasoactive Action of Melatonin. |
| melatonin | Decreases - reduced | oxidative stress | Human | COPD patients | 3mg melatonin daily. | Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study.cited 59× |
| melatonin | Decreases - alleviate | oxidative stress | Human | patients with many inflammatory diseases | — | A comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID-19 patients by phytotherapeutic melatonin and epigallocatechin-3-gallate.cited 9× |
| melatonin | Decreases - protecting organisms from | oxidative stress | Human | organisms in autoimmune, respiratory, and cardiovascular illnesses | — | A comprehensive review on modulation of SIRT1 signaling pathways in the immune system of COVID-19 patients by phytotherapeutic melatonin and epigallocatechin-3-gallate.cited 9× |
| melatonin | Decreases - leads to inhibition | oxidative stress | Human | PD | Not specified | Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms.cited 47× |
| Melatonin | Decreases - demonstrated a strong capacity to reduce | oxidative stress | Human | growth-restricted offspring | Not specified | The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review. |
| Melatonin | Decreases - reducing | oxidative stress | Human | dairy cows | Not specified | Bioactive Peptides in Dairy Milk: Highlighting the Role of Melatonin.cited 1× |
| melatonin | Decreases - has beneficial properties | oxidative stress | Human | — | Not specified (mentions "supraphysiological dosages" but no exact amounts). | Melatonin: action as antioxidant and potential applications in human disease and aging.cited 197× |
| Melatonin | Decreases - reduces | oxidative stress | Human | human newborns with sepsis, hypoxic distress, or other conditions | Not specified | Update on the use of melatonin in pediatrics.cited 62× |
| melatonin | Decreases - reduces | oxidative stress | Human | — | Not specified | Melatonin as a free radical scavenger in the ovarian follicle.cited 138× |
| melatonin | Decreases - potentials of using melatonin, as a reducer | oxidative stress | Human | women infertility | Not specified | Melatonin and hypothalamic-pituitary-gonadal axis.cited 47× |
| melatonin | Decreases - reduced | oxidative stress | Human | reproductive organ cells | Not specified | Clinical relevance of melatonin in ovarian and placental physiology: a review.cited 63× |
| melatonin | Decreases - had beneficial effects | oxidative stress | Human | ex vivo whole blood model | 20, 30, 50, and 100 mg oral doses. | Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis.cited 121× |
| melatonin | No effect - effects on | oxidative stress | Human | — | Not specified | Effects of melatonin on oxidative stress, and resistance to bacterial, parasitic, and viral infections: a review.cited 52× |
| melatonin | Decreases - potential as an alternative to conventional drug therapies for the disorders associated with the MS | oxidative stress | Human | experimental animal models of diabetes, obesity and MS | Pharmacological doses between 5 and 20 mg/kg body weight in animal models; clinical studies used 0.050–0.16 mg/kg body weight. | Melatonin and metabolic regulation: a review.cited 56× |
| melatonin | Decreases - decrease | oxidative stress | Animal | — | Not specified | Protective actions of melatonin and growth hormone on the aged cardiovascular system.cited 22× |
| melatonin | Decreases - may be potential agents for counteracting | oxidative stress | Animal | aging heart | Not specified | Protective actions of melatonin and growth hormone on the aged cardiovascular system.cited 22× |
| Melatonin | Decreases - uncommonly effective in reducing | oxidative stress | Human | — | Not specified | Melatonin as an antioxidant: under promises but over delivers.cited 1,080× |
| Melatonin | Decreases - reduces the formation of the devastatingly toxic hydroxyl radical resulting in the reduction of | oxidative stress | Human | — | Not specified | Melatonin as an antioxidant: under promises but over delivers.cited 1,080× |
| melatonin | Decreases - is a powerful antioxidant that resists oxidative stress | oxidative stress | Human | — | Not specified (mentions low vs. high doses but no exact amounts). | Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. |
| melatonin | Decreases - is a powerful antioxidant that resists oxidative stress | oxidative stress | Human | — | Not specified (mentions low vs. high doses but no exact amounts). | Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. |
| melatonin (MLT) | Decreases - possesses a number of antidiabetic health benefits | oxidative stress | HumanMolecular | in vitro and in vivo studies | Not specified | Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer.cited 7× |
| melatonin | No effect - effect | oxidative stress | Human | obese patients on a calorie-restricted diet | 10 mg daily | Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet.cited 47× |
| melatonin | Decreases - plays an important role in limiting | oxidative stress | Human | — | Melatonin with adenosine at a 1:4 ratio, stabilized with 30% glycine (MLT-DBM). | Melatonin with adenosine solubilized in water and stabilized with glycine for oncological treatment - technical preparation, effectivity and clinical findings.cited 3× |
| melatonin | Decreases - reduced | oxidative stress (8-isoprostane) | Human | xanthine/xanthine oxidase (X/XO) placental explant model | Not specified in the abstract. | Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia.cited 102× |
| melatonin | Decreases - significant antioxidant effects | oxidative stress | Human | — | Not specified | Melatonin is a potential inhibitor of ovarian cancer: molecular aspects.cited 26× |
| melatonin | Decreases - oxidative stress reduction | oxidative stress | Human | — | Not specified | Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies.cited 23× |
| simultaneous administration of propolis and melatonin | No effect - effects | oxidative stress markers | Human | patients with primary sepsis | Not specified | Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies.cited 23× |
| Melatonin | Decreases - has antioxidant properties | oxidative stress | Molecular | — | Not specified | Melatonin and its ubiquitous anticancer effects. |
| Melatonin | Decreases - has antioxidant properties | oxidative stress | Molecular | — | Not specified | Melatonin and its ubiquitous anticancer effects. |
| melatonin | Decreases - evoked antioxidant activity | oxidative stress | HumanMolecular | osteosarcoma models | Not specified | Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma.cited 35× |
| melatonin | No effect - has antioxidant properties | oxidative stress | Human | — | Not specified | Role of melatonin in periodontal disease - A systematic review.cited 12× |
| melatonin | Decreases - may play a pivotal role in protecting the tissue | tissue damage caused by oxidative stress | Human | — | Not specified | Role of melatonin in periodontal disease - A systematic review.cited 12× |
| melatonin | Decreases - efficacy in reducing | oxidative stress | Human | animals | Not specified | Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy.cited 11× |
| melatonin | Decreases - reduced | oxidative stress | Human | — | Not specified | The role of melatonin on radiation-induced pneumonitis and lung fibrosis: A systematic review.cited 21× |
| melatonin | No effect - play a part in | oxidative stress | Human | — | — | Could melatonin have a potential adjuvant role in the treatment of the lasting anosmia associated with COVID-19? A review.cited 2× |
| melatonin | Decreases - has antioxidant properties | oxidative stress | Human | pregnancies complicated by placental insufficiency | — | The role of melatonin in pregnancies complicated by placental insufficiency: A systematic review.cited 7× |
| melatonin | Increases - induce | oxidative stress | Molecular | cancer cells | Not specified. | Melatonin modulates tumor metabolism and mitigates metastasis.cited 10× |
| melatonin | Decreases - is a potent ... antioxidant | oxidative stress | Human | — | Not specified | Secondary glaucoma: Toward interventions based on molecular underpinnings.cited 5× |
| melatonin | Decreases - scavenging free radicals | oxidative stress | Human | — | Not specified | Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders.cited 7× |
| melatonin | Decreases - attenuates | oxidative stress | Human | — | Not specified | Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer.cited 3× |
| melatonin | Decreases - is a potential antioxidant that may prevent damage from | oxidative stress | Human | patients with PCOS | Not specified | Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.cited 6× |
| melatonin supplementation | Decreases - reduce | oxidative stress | Human | patients with PCOS | Not specified | Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.cited 6× |
| melatonin | Decreases - reducing | oxidative stress | Molecular | cardiac cells | Not specified | Insight into the cardioprotective effects of melatonin: shining a spotlight on intercellular Sirt signaling communication.cited 1× |
| melatonin | Decreases - resulting in reduced | oxidative stress | Animal | pancreatic cancer xenograft model in rats | 50 mg/kg, intraperitoneally, three times per week | Melatonin augments anti-tumor activity and alleviates nephrotoxicity of gemcitabine in a pancreatic cancer xenograft model targeting P62/Keap1 pathway. |
| melatonin | Decreases - demonstrated protective effects | oxidative stress | Human | — | Not specified | Unveiling the Protective Roles of Melatonin on Glial Cells in the Battle Against Alzheimer's Disease-Insights from In Vivo and In Vitro Studies. |
| melatonin | Decreases - suppressed | oxidative stress | Animal | — | — | Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota. |
| melatonin | Decreases - reduced | oxidative stress | Human | human participants | — | Differential Function of Melatonin MT |
| melatonin | Decreases - reduced | oxidative stress | HumanAnimalMolecular | cisplatin-treated mouse testes and Leydig cells | — | Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway. |
| melatonin | Decreases - may reduce | oxidative stress | Human | — | — | Melatonin reduces β-amyloid accumulation and improves short-term memory in streptozotocin-induced sporadic Alzheimer's disease model. |
| Melatonin | Decreases - significantly reduced | oxidative stress | Human | patients with metabolic syndrome | — | Melanogenesis Is Directly Affected by Metabolites of Melatonin in Human Melanoma Cells. |
| melatonin | Decreases - attenuated | oxidative stress | AnimalMolecular | mice | — | Alleviation of inflammation in paraventricular nucleus and sympathetic outflow by melatonin efficiently repairs endplate porosities and attenuates spinal hyperalgesia. |
| melatonin | Decreases - reduces | oxidative stress | Human | critically ill patients | Not mentioned | Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.cited 159× |
| melatonin (MEL) | Decreases - reduced | oxidative stress | Animal | rats | — | The vascular influence of melatonin on endothelial response to angiotensin II in diabetic rat aorta. |
| melatonin | No effect - modulation | oxidative stress | Human | — | Not available | A Review of Data of Findings on Night Shift Work and the Development of DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms.cited 58× |
| melatonin | Decreases - reduces | oxidative stress | Human | — | Not specified | Melatonin role in skeletal muscle disorders.cited 12× |
| melatonin | Decreases - controls | oxidative stress and apoptosis | HumanMolecular | myocardial tissue | — | Cellular signalling of melatonin and its role in metabolic disorders. |
| melatonin (Mel) | Decreases - preventing | oxidative stress and cell death | HumanMolecular | neurons exposed to Aβ-induced neurotoxicity | Not specified. | Role of Melatonin in Aluminum-Related Neurodegenerative Disorders: a Review.cited 18× |
| melatonin | Decreases - can rescue | oxidative stress and cell viability | HumanMolecular | cells subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) | Not specified | Melatonin ameliorates ischemic brain injury in experimental stroke by regulation of miR-221 and ATG7 axis. |
| melatonin | Decreases - resist oxidative stress and protect against common pathophysiological disorders | oxidative stress and common pathophysiological disorders | Human | during implantation, gestation and fetal development | Not specified | Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome.cited 7× |
| melatonin | Decreases - protection | oxidative stress and inflammation | Human | renal disorders | Not specified | The role of melatonin treatment in chronic kidney disease.cited 38× |
| melatonin | Decreases - effective antioxidants and anti-inflammation | oxidative stress and inflammatory response | Human | — | Not provided | The Potentials of Melatonin in the Prevention and Treatment of Bacterial Meningitis Disease.cited 9× |
| melatonin | Decreases - may regulate the immune system by modulating oxidative stress and inflammatory states during infections | oxidative stress and inflammatory states | Human | — | Not specified | The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review.cited 20× |
| melatonin | Increases - role in obesity is mainly related to improved oxidative stress signaling | oxidative stress signaling | Human | — | Not specified | The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review.cited 20× |
| melatonin | Decreases - target the acute injury phase | oxidative stress associated with hypoxic-ischemic encephalopathy | Human | — | Not specified | Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia.cited 63× |
| melatonin | Decreases - ameliorates | oxidative stress caused by ROS and NOS | Human | — | Not specified | A new prospective on the role of melatonin in diabetes and its complications.cited 22× |
| melatonin | Decreases - may mitigate | oxidative stress from chronic nicotine exposure | Human | — | Not specified | Exploring the association between melatonin and nicotine dependence (Review).cited 1× |
| melatonin | Decreases - mitigates | oxidative stress in acrylamide-induced lung injury | Animal | rats | — | The effects of melatonin on oxidative stress, inflammation, apoptosis and Nrf2/HO-1 in acrylamide-induced lung injury in rats. |
| melatonin | Decreases - has shown the protective role for preventing oxidative stress-induced mitochondrial dysfunction | oxidative stress-induced mitochondrial dysfunction | Human | experimental models of PD, AD, and HD | Not specified | Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders.cited 52× |
| melatonin | Decreases - is an ideal antioxidant to protect tissue | oxidative stress-induced secondary damage after SCI | Human | — | Not specified | Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury.cited 57× |
| melatonin plus exercise treatment | Increases - may be a more effective therapy | functional recovery and oxidative stress-induced secondary damages after SCI | Human | — | Not specified | Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury.cited 57× |
| melatonin | Decreases - protecting and reducing oxidative stress in mitochondria, can normalize homeostasis and mitochondrial function and ultimately prevent apoptosis and cell death | oxidative stress in mitochondria, homeostasis, mitochondrial function, apoptosis, cell death | Human | — | Not specified | Melatonin: a pleiotropic hormone as a novel potent therapeutic candidate in arsenic toxicity.cited 14× |
| Melatonin | Decreases - decreased | oxidative stress markers | Human | human participants | — | Nociceptive responses in melatonin MT |
| Melatonin | No effect - did not change | oxidative stress markers | Animal | anesthetized rats | — | Blockade of Melatonin Receptors Abolishes Its Antiarrhythmic Effect and Slows Ventricular Conduction in Rat Hearts. |
| melatonin | Decreases - seemed to reduce | oxidative stress markers | Animal | rats or rabbits subjected to pneumoperitoneum, or pneumoretroperitoneum | Not specified | Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review.cited 3× |
| melatonin | Decreases - effective to prevent | oxidative stress/nitrosative stress-induced mitochondrial dysfunction | Human | experimental models of AD, PD and HD | 50-100mg/day (therapeutic range suggested for neurodegenerative disorders). | Melatonin and mitochondrial dysfunction in the central nervous system.cited 67× |
| melatonin | Decreases - has significant antioxidative capabilities which may protect against | oxidative stress of infertility treatment on gametes and embryos | Human | — | 2 mg twice per day, 4 mg twice per day, and 8 mg twice per day. | A pilot double-blind randomised placebo-controlled dose-response trial assessing the effects of melatonin on infertility treatment (MIART): study protocol.cited 11× |
| melatonin | Decreases - reduces | oxidative stress on bone cells | HumanAnimalMolecular | in vitro | Not specified | Melatonin and the skeleton.cited 66× |
| melatonin | Increases - significant impact on improving | Oxidative stress parameters | Human | unhealthy patients | Not specified | Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.cited 52× |
| melatonin | No effect - regulate | oxidative stress response pathways | Molecular | — | Not specified | Melatonin and retinal cell damage: molecular and biological functions. |
| Melatonin | Decreases - effectively protects | pancreatic tissue against oxidative stress and inflammatory damage | Molecular | — | High doses (specific amounts not stated) for pro-apoptotic effects; low doses for anti-apoptotic effects. | Melatonin influences pancreatic cancerogenesis.cited 18× |
| melatonin (5 mg) | No effect - no statistically significant between-group differences | Perceived Stress Scale (PSS-14) | Human | males 18 years of age and older in recovery from substance use | 5 mg melatonin daily. | The Effect of Melatonin Upon Postacute Withdrawal Among Males in a Residential Treatment Program (M-PAWS): A Randomized, Double-blind, Placebo-controlled Trial.cited 3× |
| melatonin | Increases - plays a crucial role in enhancing | plant resistance to salt stress | Animal | plant | Not specified | Melatonin enhances salt tolerance by promoting CcCAD10-mediated lignin biosynthesis in pigeon pea. |
| melatonin | No effect - did not differ | Post-traumatic stress disorder prevalence | Human | critically-ill with mechanical ventilation >48 hours and Simplified Acute Physiology Score II>32 points | 3 mg at 8 p.m. and 3 mg at midnight. | Melatonin reduces the need for sedation in ICU patients: a randomized controlled trial.cited 66× |
| Melatonin | Decreases - attenuated | production of tunicamycin-induced endoplasmic reticulum (ER) stress-sensing proteins | AnimalMolecular | — | — | Melatonin improves uterine-conceptus interaction via regulation of SIRT1 during early pregnancy. |
| melatonin | No effect - influences | response to circadian disruption, stress and burnout syndrome | Human | animals and humans | Not specified | Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases.cited 41× |
| melatonin | Decreases - has protective effects against | RF/ELF-EMF-induced oxidative stress | Human | — | Not specified. | Melatonin: a Potential Shield against Electromagnetic Waves.cited 4× |
| melatonin | Decreases - significant decrease | serum concentration of pro-inflammatory cytokines and oxidative stress markers | Human | patients with relapsing-remitting multiple sclerosis (RRMS) | 25 mg/d orally. | Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis.cited 65× |
| melatonin | Decreases - effectively ameliorated | sleep deprivation-caused oxidative stress-mediated gut microbiota disorder and colitis | Animal | — | — | The Role of |
| melatonin | Decreases - attenuate | subcellular oxidative stress | Human | — | Not specified | Melatonin ameliorates the drug induced nephrotoxicity: Molecular insights.cited 24× |
| melatonin | Decreases - protects | the developing fetus from oxidative stress | Molecular | developing fetus | Not specified | Melatonin and the circadian system: contributions to successful female reproduction.cited 149× |
| melatonin | Decreases - is a powerful free radical scavenger and protects | the oocyte from oxidative stress | Molecular | — | Not specified | Melatonin and the circadian system: contributions to successful female reproduction.cited 149× |
| melatonin | Decreases - showed high potency in reduction of | the oxidative stress and inflammation markers | Human | — | Not specified | Exercise-induced oxidative stress and melatonin supplementation: current evidence.cited 49× |
| melatonin | No effect - impacts on | the tryptophan catabolic pathway via its effect on stress response and cortisol secretion | Human | — | Not specified | Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects.cited 59× |
| melatonin | Decreases - could modulate | TME oxidative stress levels | HumanMolecular | — | Not mentioned | Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance.cited 13× |
| exogenous melatonin (MT) | Decreases - alleviated | growth damage caused by PEG-simulated drought stress | Animal | Camellia hainanica seedlings | 0, 50, 100, 150, 200, and 250 μmol/L applied through irrigation. | Influence of Exogenous Melatonin on the Physiological Traits of Camellia hainanica Seedlings Under Polyethylene Glycol-Induced Drought Stress. |
| propolis alone, propolis plus melatonin, and melatonin alone | No effect - no significant difference was observed between the groups in terms of | oxidative stress and hematological indices | Human | patients with primary pneumosepsis | — | Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients with Primary Pneumosepsis: A Randomized Controlled Clinical Trial.cited 17× |
| melatonin alone (20 mg/day) | No effect - investigated the effects of | inflammation, clinical outcomes, and oxidative stress markers | Human | patients with primary pneumosepsis | — | Effects of Melatonin and Propolis Supplementation on Inflammation, Oxidative Stress, and Clinical Outcomes in Patients with Primary Pneumosepsis: A Randomized Controlled Clinical Trial.cited 17× |
| melatonin concentrations | Decreases - were negatively correlated with | concentration of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative stress marker | HumanMolecular | women undergoing in vitro fertilization and embryo transfer (IVF-ET) | 3 mg/day at 22:00 hr (clinical trial); 1, 10, 100 μg/mL (in vitro). | Protective role of melatonin in progesterone production by human luteal cells.cited 65× |
| Pretreatment with melatonin (10 mg/kg) | Decreases - Reduction in | oxidative stress | Animal | prediabetic obese rats | — | Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats. |
| long-term melatonin treatment | No effect - were not significantly affected | many of the circadian and behavioral parameters measured, including oxidative stress markers | Animal | APPswe/PS1 double transgenic (Tg) mouse model of AD | — | Circadian system functionality, hippocampal oxidative stress, and spatial memory in the APPswe/PS1dE9 transgenic model of Alzheimer disease: effects of melatonin or ramelteon. |
| melatonin supplementation through capsules | Decreases - has been shown to be efficient | oxidative stress | Human | — | Not specified | Melatonin intake and potential chronobiological effects on human health.cited 24× |
| combination of agmatine and melatonin | Decreases - may result from suppressing | oxidative stress | Animal | — | Agmatine (1 mg/kg/day), melatonin (10 mg/kg/day), and fluoxetine (10 mg/kg/day). | Study of the Antidepressant Effects of the Combination of Agmatine and Melatonin Following Restraint Stress in Mice: the Role of Oxidative Factors. |
| combination of agmatine and melatonin | No effect - improves | stress-induced depression | Animal | mice | Agmatine (1 mg/kg/day), melatonin (10 mg/kg/day), and fluoxetine (10 mg/kg/day). | Study of the Antidepressant Effects of the Combination of Agmatine and Melatonin Following Restraint Stress in Mice: the Role of Oxidative Factors. |
| melatonin treatment | No effect - remained | effects on parenting stress | Human | children with delayed Dim Light Melatonin Onset | Not specified (treatment involved full dose for 3 weeks, half dose for 1 week, then discontinuation). | Termination of short term melatonin treatment in children with delayed Dim Light Melatonin Onset: effects on sleep, health, behavior problems, and parenting stress.cited 15× |
| melatonin treatment | Decreases - had positive effects | parenting stress | Human | children with delayed Dim Light Melatonin Onset | Not specified (treatment involved full dose for 3 weeks, half dose for 1 week, then discontinuation). | Termination of short term melatonin treatment in children with delayed Dim Light Melatonin Onset: effects on sleep, health, behavior problems, and parenting stress.cited 15× |
| melatonin treatment | Decreases - alleviated | endoplasmic reticulum stress | Animal | mice exposed to MI/R injury | — | Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury. |
| melatonin treatment | Decreases - suppressed | MI/R-initiated myocardial oxidative stress | Animal | mice exposed to MI/R injury | — | Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury. |
| melatonin treatment | Decreases - suppressed | nitrative stress | Animal | mice exposed to MI/R injury | — | Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury. |
| melatonin treatment | No effect - modulated | expression of genes involved in autophagy and oxidative stress | HumanAnimalMolecular | primary fibroblasts from human HS (HSFs) | — | Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling. |
| melatonin treatment | Decreases - alleviated | heat stress-induced oxidative apoptosis and proliferation inhibition | AnimalMolecular | GC-2spd (ts) spermatocyte cell line model | Not specified. | Melatonin Ameliorates Heat Stress-Induced Oxidative Apoptosis in Mouse Spermatocytes via Autophagy and Ferroptosis Pathways. |
| melatonin intervention | Decreases - significantly reduced | testicular accumulation of malondialdehyde (MDA) induced by heat stress | AnimalMolecular | murine heat stress model | Not specified. | Melatonin Ameliorates Heat Stress-Induced Oxidative Apoptosis in Mouse Spermatocytes via Autophagy and Ferroptosis Pathways. |
| melatonin treatment | Decreases - rescued | increase of oxidative stress arising by H/R injury | AnimalMolecular | aortic endothelial cells (pAECs) | Not available | Melatonin rescues cell respiration impaired by hypoxia/reoxygenation in aortic endothelial cells and affects the mitochondrial bioenergetics targeting the F1FO-ATPase. |
| melatonin treatment | Decreases - mitigated | oxidative stress | Animal | mice with SCI | — | Melatonin exerts neuroprotective effects in mice with spinal cord injury by activating the Nrf2/Keap1 signaling pathway via the MT2 receptor. |
| melatonin treatment | Decreases - protected | primary cultured normal and GCD2 corneal fibroblasts from paraquat (PQ)-induced oxidative stress | Molecular | primary cultured normal and GCD2-homozygous corneal fibroblasts | — | Melatonin protects against oxidative stress in granular corneal dystrophy type 2 corneal fibroblasts by mechanisms that involve membrane melatonin receptors. |
| Supplemental melatonin | Decreases - showed improvement in | parenting stress | Human | parents | 1 or 3 mg | Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes.cited 146× |
| oral consumption of N-acetyl cysteine (NAC) and melatonin (ML) | Decreases - reducing | early reperfusion injury and acute oxidative stress | Human | patients undergoing coronary artery bypass grafting (CABG) | Not specified in the abstract. | Effects of N-acetyl cysteine and melatonin on early reperfusion injury in patients undergoing coronary artery bypass grafting: A randomized, open-labeled, placebo-controlled trial.cited 36× |
| melatonin (ML) and N-acetyl cysteine (NAC) | Decreases - are potent antioxidants with similar efficacy in terms of reducing | CABG related cardiac injury and oxidative stress | Human | patients undergoing coronary artery bypass grafting (CABG) | Not specified in the abstract. | Effects of N-acetyl cysteine and melatonin on early reperfusion injury in patients undergoing coronary artery bypass grafting: A randomized, open-labeled, placebo-controlled trial.cited 36× |
| 0.02 mmol·L-1 exogenous melatonin treatment | Decreases - had the best effect on | NaCl stress alleviation | Animal | G. biloba seedlings under salt stress | Melatonin solution (0, 0.02, 0.1, 0.5 mmol·L-1) applied via leaf spray and soil watering | Effects of exogenous melatonin on the osmotic regulation and antioxidant capacity of Ginkgo biloba seedlings under salt stress.cited 2× |
| 0.02 and 0.1 mmol·L-1 exogenous melatonin | Decreases - alleviated | osmotic stress | Animal | G. biloba seedlings under salt stress | Melatonin solution (0, 0.02, 0.1, 0.5 mmol·L-1) applied via leaf spray and soil watering | Effects of exogenous melatonin on the osmotic regulation and antioxidant capacity of Ginkgo biloba seedlings under salt stress.cited 2× |
| 0.02 and 0.1 mmol·L-1 exogenous melatonin | Decreases - alleviated | oxidative stress | Animal | G. biloba seedlings under salt stress | Melatonin solution (0, 0.02, 0.1, 0.5 mmol·L-1) applied via leaf spray and soil watering | Effects of exogenous melatonin on the osmotic regulation and antioxidant capacity of Ginkgo biloba seedlings under salt stress.cited 2× |
| exogenously administered melatonin | Decreases - seems to attenuate | oxidative stress | Human | professional football players | 5-8 mg | The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review.cited 6× |
| melatonin supplementation | Decreases - reduced oxidative stress | oxidative stress | Human | — | 5-8 mg | The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review.cited 6× |
| melatonin supplementation | Decreases - showed a decrease | oxidative stress | Human | melatonin-treated group | 5-8 mg | The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review.cited 6× |
| Knockout of both melatonin receptors type 1A (MT1) and 1B (MT2) | Increases - exacerbated | oxidative stress | Animal | aging mice | — | Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice. |
| melatonin supplementation | No effect - investigate the change in | oxidative stress | Human | MS patients | 3 mg/night | 12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial. |
| melatonin supplementation | Decreases - demonstrated affirmative effects in decreasing | oxidative stress | Human | SLE patients | 10 mg/day | Effects of melatonin supplementation on serum oxidative stress markers and disease activity in systemic lupus erythematosus patients: A randomised, double-blind, placebo-controlled trial.cited 10× |
| melatonin supplementation | Decreases - is a promising complementary strategy to attenuate | oxidative stress | Human | diabetic patients | Not specified in the abstract. | Effects of melatonin supplementation on markers of inflammation and oxidative stress in patients with diabetes: A systematic review and meta-analysis of randomized controlled trials.cited 11× |
| melatonin supplementation | Decreases - normalized | oxidative stress | Animal | DSS-treated mice | — | Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways. |
| melatonin supplementation | Decreases - had a significant impact on attenuating | oxidative stress | Human | — | — | Melatonin effectiveness in amelioration of oxidative stress and strengthening of antioxidant defense system: Findings from a systematic review and dose-response meta-analysis of controlled clinical trials.cited 23× |
| melatonin supplementation | Increases - was associated with enhanced | oxidative stress and inflammation status | Human | patients with MS | Not specified | Clinical efficacy and safety of melatonin supplementation in multiple sclerosis: a systematic review.cited 11× |
| melatonin supplementation | Decreases - reduced | oxidative stress markers | Human | patients with type 2 diabetes | Not available | Molecular Mechanisms of the Melatonin Receptor Pathway Linking Circadian Rhythm to Type 2 Diabetes Mellitus. |
| melatonin supplementation | Decreases - reduced | oxidative stress markers | Human | patients with type 2 diabetes | Not available | Molecular Mechanisms of the Melatonin Receptor Pathway Linking Circadian Rhythm to Type 2 Diabetes Mellitus. |
| Melatonin and 5-MTP | Increases - protecting | MSCs against replicative and stress-induced cellular senescence | Molecular | mesenchymal stromal/stem cells (MSCs) | Not specified | Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites.cited 18× |
| pharmacological doses of melatonin | Decreases - have antioxidative properties | oxidative stress | Molecular | various in vitro cellular models | Pharmacological doses mentioned (specific amounts not provided). | Melatonin in energy control: Circadian time-giver and homeostatic monitor.cited 7× |
| sericin and melatonin | Decreases - alleviated | testicular tissues from oxidative stress and dysregulated spermatogenesis and steroidogenesis | Animal | male Swiss albino mice | — | Sericin and melatonin mitigate diethylnitrosamine-instigated testicular impairment in mice: Implications of oxidative stress, spermatogenesis, steroidogenesis, and modulation of Nrf2/WT1/SF-1 signaling pathways. |
| melatonin therapy | Decreases - alleviation | oxidative stress | Human | preclinical studies | Not specified | Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies.cited 42× |
| melatonin therapy | Decreases - significantly improved | tissue markers of oxidative stress | Animal | male rodents | Not specified | Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies.cited 8× |
| melatonin therapy | Increases - was associated with improved | tissue markers of oxidative stress | Animal | male rodents with physical, ischemic, and thermal testicular injuries | — | Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models.cited 14× |
| melatonin therapy after the stroke | Decreases - cause to alleviate | ER stress | Human | — | Not specified | Effect of Melatonin on Endoplasmic Reticulum-Mitochondrial Crosstalk in Stroke.cited 17× |
| 25 mg oral melatonin nightly | No effect - no significant differences | brain oxidative stress | Human | Participants with Mild Cognitive Impairment (MCI) | 25 mg nightly | 3-Month Melatonin Supplementation to Reduce Brain Oxidative Stress and Improve Sleep in Mild Cognitive Impairment: A Randomised Controlled Feasibility Trial.cited 1× |
| maternal melatonin administration | Decreases - ameliorated | oxidative stress | HumanAnimal | IUGR lamb brains | Not specified (intravenous infusion in sheep, oral administration in humans). | Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction.cited 126× |
| melatonin and its metabolites | Decreases - operating as free radical scavengers | oxidative stress | Human | — | Not specified | Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective. |
| melatonin and its metabolites | Decreases - operating as free radical scavengers | oxidative stress | Human | — | Not specified | Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective. |
| endogenous melatonin | Decreases - attenuates | oxidative stress | Human | — | Not specified. | Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease. |
| endogenous melatonin | Decreases - attenuates | oxidative stress | Human | — | Not specified. | Mechanisms of esophageal protection, gastroprotection and ulcer healing by melatonin. implications for the therapeutic use of melatonin in gastroesophageal reflux disease (GERD) and peptic ulcer disease. |
| antioxidant functionality, represented by coumarins, melatonin and other antioxidant molecules | Decreases - reduces the level of | oxidative stress | Human | — | Not specified | Management of oxidative stress and other pathologies in Alzheimer's disease.cited 169× |
| Resveratrol and melatonin | Decreases - reduce oxidative stress | oxidative stress | Molecular | — | Not provided. | The role and therapeutic potential of SIRTs in sepsis.cited 5× |
| andrographolide (AGP) and melatonin (MLT) in combination | Increases - induction of | ER stress proteins | Molecular | metastatic colon cancer cells | Serial dilutions (specific amounts not stated). | Synergistic potential of dual andrographolide and melatonin targeting of metastatic colon cancer cells: Using the Chou-Talalay combination index method.cited 36× |
| administration of melatonin | Decreases - may help modulate | oxidative stress | Human | patients undergoing CABG | 12 mg sublingual melatonin the evening before and 1 hour before surgery. | The Effects of Melatonin on the Oxidative Stress and Duration of Atrial Fibrillation after Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial.cited 16× |
| melatonin and 2-hydroxymelatonin | Increases - functioning as antioxidants | stress adaptation | HumanMolecular | intact and cut tobacco leaves | 20% tulsi extract in culture medium | Enhanced In Vitro Plant Morphogenesis of Tobacco: Unveiling Indoleamine-Modulated Adaptogenic Properties of Tulsi (Ocimum sanctum L.).cited 2× |