melatonin Increases - improved sleep quality Human
patients with chronic tinnitus 3 mg nightly Melatonin: can it stop the ringing? cited 27× melatonin (5mg) Increases - improved sleep quality Human
females, aged 20-40 years, with myofascial TMD pain 5mg daily. Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study. cited 49× melatonin Increases - improved sleep quality Human
Forty females, aged 18 to 45 years 10 mg melatonin daily. Efficacy of melatonin in the treatment of endometriosis: a phase II, randomized, double-blind, placebo-controlled trial. cited 98× Melatonin No effect - No significant effects of trial duration and melatonin dose were observed on sleep quality Human
— Not specified (higher doses showed greater effects). Meta-analysis: melatonin for the treatment of primary sleep disorders. cited 269× melatonin Increases - benefit sleep quality Human
certain people 3 mg of oral melatonin administered at 9:00 pm. Impact of oral melatonin on critically ill adult patients with ICU sleep deprivation: study protocol for a randomized controlled trial. cited 15× melatonin No effect - evaluate the effect sleep quality Human
ICU patients 3 mg of oral melatonin administered at 9:00 pm. Impact of oral melatonin on critically ill adult patients with ICU sleep deprivation: study protocol for a randomized controlled trial. cited 15× melatonin Increases - improves sleep quality Human
patients with AD and PD Not specified Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials. cited 62× melatonin Increases - a trend towards an improved sleep quality Human
subgroup of women with sleep disturbances at baseline 1 mg or 3 mg nightly. The effect of melatonin treatment on postural stability, muscle strength, and quality of life and sleep in postmenopausal women: a randomized controlled trial. cited 41× melatonin Increases - possible symptomatic improvements seen sleep quality Human
Alzheimer's patients Not specified Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases. cited 20× melatonin Increases - appears to be effective and safe in improving sleep quality Human
patients with AD Not specified in the abstract. Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer's disease. cited 54× melatonin Increases - improves sleep quality Human
critically ill patients Not mentioned Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. cited 159× melatonin No effect - assess impact upon sleep quality Human
MS patients 2 mg at bedtime. Protocol for a randomized, double blind, placebo controlled, crossover trial of Melatonin for treatment of Nocturia in adults with Multiple Sclerosis (MeNiMS). cited 8× melatonin Increases - perhaps improvement sleep quality Human Animal
women receiving melatonin vs placebo — Biological effects of melatonin on osteoblast/osteoclast cocultures, bone, and quality of life: Implications of a role for MT2 melatonin receptors, MEK1/2, and MEK5 in melatonin-mediated osteoblastogenesis. melatonin No effect - did not significantly change sleep quality Human
BMS patients 12 mg/day Melatonin Treatment in Patients with Burning Mouth Syndrome: A Triple-Blind, Placebo-Controlled, Crossover Randomized Clinical Trial. cited 18× melatonin Increases - improved sleep sleep quality Human
adults in the intensive care unit Not specified (doses varied between studies). Melatonin for the promotion of sleep in adults in the intensive care unit. cited 56× melatonin Increases - showed a significant advantage over oxazepam in improving sleep quality Human
STEMI patients managed with primary PCI 3 mg every night Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial. cited 9× melatonin Increases - could be more effective than oxazepam in improving sleep quality Human
patients presenting with STEMI 3 mg every night Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial. cited 9× melatonin Increases - improved sleep quality Human
human participants — Differential Function of Melatonin MT Melatonin Increases - improved sleep quality Human
human participants — Nociceptive responses in melatonin MT Melatonin Increases - improved sleep quality Human
older adults with insomnia — Melatonin receptor ligands: A pharmaco-chemical perspective. Melatonin Increases - improved sleep quality Human
patients with insomnia — MT Melatonin Increases - improved sleep quality Human
Patients with rare MTNR1B variants — Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study. Melatonin Increases - improved sleep quality Human
T2D MTNR1B variant carriers — Circadian, Sleep and Caloric Intake Phenotyping in Type 2 Diabetes Patients With Rare Melatonin Receptor 2 Mutations and Controls: A Pilot Study. melatonin Increases - significantly beneficial to improve sleep quality Human
— Not specified Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis. cited 30× melatonin Increases - observed sleep quality Human
ASD Not specified Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder. cited 49× melatonin No effect - resulted in no benefits to sleep quality Human
menopausal women 1 mg to 5 mg (varied by study). Effects of exogenous melatonin on sleep quality and menopausal symptoms in menopausal women: a systematic review and meta-analysis of randomized controlled trials. cited 9× melatonin No effect - showed no significant improvement on sleep quality Human
patients with cancer 3 mg to 20 mg, usually taken nightly before bedtime The effect of melatonin on sleep quality and insomnia in patients with cancer: a systematic review study. cited 23× melatonin Increases - improving sleep quality Human Animal
— — An Integrative Transcriptomic and Metabolomic Study Revealed That Melatonin Plays a Protective Role in Chronic Lung Inflammation by Reducing Necroptosis. melatonin No effect - showed no difference in sleep quality Human
ICU patients — Sleep in the intensive care unit. cited 7× melatonin (MLT) No effect - had no significant effect on sleep quality Human
patients with cancer — Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. cited 10× melatonin No effect - no statistically significant differences sleep quality Human
patients — Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. melatonin Increases - beneficial to sleep quality Human
individuals with sleep disturbance after TBI — The Utility of Melatonin for the Treatment of Sleep Disturbance After Traumatic Brain Injury: A Scoping Review. cited 8× Melatonin Increases - is a potential therapeutic intervention for improving sleep quality Human
people with autistic spectrum disorder (ASD) — Melatonin for sleep disorders in people with autism: Systematic review and meta-analysis. cited 20× melatonin Increases - can favor sleep quality Human
— Not specified Therapeutic effects of melatonin on endometriosis, targeting molecular pathways: Current knowledge and future perspective. cited 4× melatonin Increases - improvement of sleep quality Human
— Not specified Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management. cited 15× Melatonin Increases - found to provide a clinically important benefit sleep quality Human
patients after total joint arthroplasty (TJA) Not specified Which Interventions Are Effective in Treating Sleep Disturbances After THA or TKA? A Systematic Review. cited 2× melatonin Increases - significantly increased sleep quality Human
— Not specified Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta-Analysis. melatonin Increases - significantly improved sleep quality Human
breast cancer patients undergoing hormone therapy 6 mg daily Melatonin Aids in Treating Mood and Sleep Problems Resulting from Hormonal Therapy in Breast Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial. Melatonin Increases - has been shown to improve sleep quality Human
Parkinson's disease (PD) patients Not specified Parkinson's disease: News on the action of melatonin. 
