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Evidence suggests Melatonin mayincreaseSleep.
41 studies (34 claims)
Typical dose 17.5 mg
Exact normalized-entity scope. Exact scope. Claims must match the selected normalized intervention and endpoint IDs; signal links are not expanded. Direction describes the stored endpoint phrase and is not a benefit/harm judgement.
38 of 44
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| Melatonin | Increases - increase sleep | sleep | Human | — | Not specified | Good night and good luck: norepinephrine in sleep pharmacology.cited 101× |
| melatonin | Increases - favourable effects | sleep | Human | — | Not mentioned. | Exploring the reasons why melatonin can improve tinnitus.cited 16× |
| melatonin | Increases - positively associated with greater likelihood of improvement | sleep | Human | those with absence of depression and/or anxiety at baseline | 3 mg nightly | Melatonin: can it stop the ringing?cited 27× |
| melatonin | Increases - positively associated with greater likelihood of improvement | sleep | Human | those with greater pretreatment TSI scores | 3 mg nightly | Melatonin: can it stop the ringing?cited 27× |
| melatonin | Increases - positively associated with greater likelihood of improvement | sleep | Human | those with greater pretreatment SRT scores | 3 mg nightly | Melatonin: can it stop the ringing?cited 27× |
| Melatonin | Increases - has been used for improving sleep | sleep | Human | patients with insomnia | 2-3 mg/day for melatonin; 50-100 mg/day suggested for future studies. | Melatonin and its analogs in insomnia and depression. |
| melatonin | Increases - has been used for improving | sleep | Human | patients with insomnia and circadian rhythm sleep disorders | 2-5 mg/day for sleep disorders; 50-100 mg/day proposed for MS. | Disrupted chronobiology of sleep and cytoprotection in obesity: possible therapeutic value of melatonin.cited 24× |
| melatonin | Increases - may promote | sleep | Human | — | Not specified | Emerging targets for the pharmacological treatment of depression: focus on melatonergic system. |
| Melatonin | Increases - has been shown to improve | sleep | Human | — | Not specified | Agomelatine in depressive disorders: its novel mechanisms of action. |
| melatonin | No effect - influence | sleep | HumanMolecular | — | Not specified | Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks.cited 47× |
| melatonin | No effect - plays an important role | sleep | HumanMolecular | — | Not specified | Melatonin: its possible role in the management of viral infections--a brief review.cited 48× |
| melatonin | No effect - did not affect | sleep | Human | postmenopausal women with osteopenia | 1 mg or 3 mg nightly. | The effect of melatonin treatment on postural stability, muscle strength, and quality of life and sleep in postmenopausal women: a randomized controlled trial.cited 41× |
| Melatonin | Increases - appears to improve | sleep | Human | — | Not specified | Pharmacotherapy for mental health problems in people with intellectual disability.cited 40× |
| melatonin | Increases - a suggestion of subjective benefit | sleep | Human | Parkinson's patients | Not specified | Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases.cited 20× |
| melatonin | Increases - administered to improve sleep | sleep | Human | — | 4 mg enterally once daily at 21:00. | Prophylactic Melatonin for Delirium in Intensive Care (Pro-MEDIC): study protocol for a randomised controlled trial.cited 26× |
| melatonin | Increases - has proven hypnotic effects | sleep | Human | — | 25 mg melatonin. | The effect of MElatonin on Depressive symptoms, Anxiety, CIrcadian and Sleep disturbances in patients after acute coronary syndrome (MEDACIS): study protocol for a randomized controlled trial.cited 16× |
| melatonin | No effect - adequately support the pharmacological treatment | sleep | Human | autism spectrum disorder | Not specified | Clinical trials in autism spectrum disorder: evidence, challenges and future directions.cited 36× |
| melatonin | Increases - appeared safe and effective in improving | sleep | Human | the studied children | Not specified | Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.cited 62× |
| melatonin | Increases - sleep-enhancing properties | sleep | Human | — | Not specified (mentions "recommended use" but no specific dosage). | Drugs Used in Circadian Sleep-Wake Rhythm Disturbances.cited 9× |
| melatonin | No effect - interactions between | sleep | Human | — | Not specified | Ocular and systemic melatonin and the influence of light exposure.cited 76× |
| melatonin | Increases - improvement was greatest | sleep | Human | children with autism or other neurodevelopmental disorders | Not specified | Pharmacologic Treatments for Sleep Disorders in Children: A Systematic Review.cited 25× |
| melatonin | Increases - improvement was smaller | sleep | Human | adolescents and children with chronic delayed sleep onset | Not specified | Pharmacologic Treatments for Sleep Disorders in Children: A Systematic Review.cited 25× |
| melatonin | Increases - likely have the most promise to improve | sleep | Human | inpatient medical settings | Not available | Sleepless in the hospital: A systematic review of non-pharmacological sleep interventions.cited 41× |
| melatonin | No effect - no significant effect | sleep | Human | youth (ages 8-18 years) with PPCS at 4 to 6 weeks after mild traumatic brain injury | 3 mg or 10 mg melatonin (frequency not specified). | Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.cited 30× |
| melatonin | No effect - is involved in the initiation of | sleep | Human | — | Not mentioned | Quality of life for older patients with cancer: a review of the evidence supporting melatonin use.cited 7× |
| melatonin | Increases - have shown promise for improving | sleep | Human | adults with critical conditions | Not specified | Effectiveness of complementary and alternative medicine interventions for sleep quality in adult intensive care patients: A systematic review.cited 19× |
| melatonin | Increases - sleep-enhancing | sleep | Human | — | Not specified | Drugs Used in Circadian Sleep-Wake Rhythm Disturbances.cited 8× |
| melatonin | No effect - effect on | sleep | Human | individuals with MCI | 25 mg oral melatonin nightly. | Feasibility of 3-month melatonin supplementation for brain oxidative stress and sleep in mild cognitive impairment: protocol for a randomised, placebo-controlled study.cited 7× |
| melatonin | Increases - has been implicated in promoting and maintaining | sleep | Molecular | — | Not mentioned | Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders.cited 59× |
| melatonin | No effect - maintain synchrony of sleep with the day/night cycle | sleep | Human | humans | Not specified | What do we really know about the safety and efficacy of melatonin for sleep disorders?cited 13× |
| melatonin | No effect - clinical effects | sleep | Human | patients with mild cognitive impairment and AD | Not specified | Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies.cited 42× |
| melatonin | Increases - adding a sleep-promoting agent | sleep | Human | — | — | Attention Deficit Hyperactivity Disorder Medications and Sleep.cited 5× |
| melatonin | Increases - result in improved sleep | sleep | Human | children and adolescents with autism spectrum disorder (ASD) | Not specified | The impact of the physical activity intervention on sleep in children and adolescents with autism spectrum disorder: A systematic review and meta-analysis.cited 7× |
| melatonin | Increases - widespread oral use as a dietary supplement to improve | sleep | Human | — | Not specified | Clinical Studies Using Topical Melatonin.cited 8× |
| melatonin | No effect - plays a critical role in | sleep | Human | — | Not specified | Melatonin: Evolving Physiological Understanding and Potential Therapeutic Role in Pain Medicine Including Intervertebral Disc Degeneration.cited 1× |
| Melatonin (MLT) | Increases - has long been associated with promoting and maintaining | sleep | HumanAnimal | — | — | Melatonin Induces Analgesic Effects through MT |
| Melatonin | Increases - is known for its sleep-enhancing properties | sleep | Human | — | Not specified | Melatonin in Alzheimer's Disease: Literature Review and Therapeutic Trials.cited 4× |
| Melatonin (MT) | No effect - regulating | sleep | Human | humans and animals | Not specified | Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders.cited 2× |