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Evidence suggests Melatonin haslittle to no effecton Lipid metabolism.
12 studies (3 claims)
Conflicting evidence
Typical effective dose 12.5 (8.75–16.25) mgacross 2 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin administration | No effect - regulating | lipid metabolism | Human | — | 5 mg melatonin tablets twice daily. | Effects of melatonin supplementation on metabolic parameters, oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: study protocol for a double-blind, randomized controlled trial.cited 1× |
| melatonin | No effect - impact | glucose and lipid metabolism before and after a late evening meal | Human | Nine healthy male participants (26 ± 1.3 years, BMI 24.8 ± 0.8 kg/m²) | Not available | The effect of melatonin on glucose tolerance, insulin sensitivity and lipid profiles after a late evening meal in healthy young males.cited 16× |
| melatonin | No effect - modulates | lipid metabolism | Molecular | — | Pharmacological doses mentioned (specific amounts not provided). | Melatonin in energy control: Circadian time-giver and homeostatic monitor.cited 7× |
| melatonin | No effect - review the evidence on the effect | lipid metabolism | Human | — | Not specified | The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis.cited 13× |
| melatonin treatment (HFD-Mi + M) | Increases - improving | lipid metabolism | Animal | — | Not specified | Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics. |
| melatonin supplementation at 10 μmol/L | Decreases - significantly downregulated | mRNA expression of lipid metabolism-related genes | AnimalMolecular | bovine mammary epithelial cells (BMECs) | — | Melatonin suppresses milk fat synthesis by inhibiting the mTOR signaling pathway via the MT1 receptor in bovine mammary epithelial cells. |