7
5
1
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Evidence suggests Melatonin mayincreaseLeptin sensitivity.
8 studies (13 claims)
Emerging evidence
Typical effective dose 6 (4.5–8) mgacross 3 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin (1 or 3 mg nightly) | No effect - No significant changes were observed | leptin | Human | postmenopausal women | 1 or 3 mg nightly | Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women: A randomized placebo-controlled trial.cited 53× |
| melatonin | Increases - rose significantly | leptin plasma levels | Human | patients with NASH | 10 mg/day. | Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatonin.cited 45× |
| melatonin | Decreases - counteracts | oncogenic effects of elevated concentrations of leptin | Human | — | Not Assessed | Melatonin: A Molecule for Reducing Breast Cancer Risk.cited 39× |
| melatonin | Increases - increased significantly | plasma leptin | Human | idiopathic patients with gastroduodenal chronic ulcers | Not specified (melatonin dosage not mentioned). | Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole.cited 25× |
| exogenous melatonin | Decreases - were lower | plasma leptin concentrations | Animal | Siberian hamster | Not specified | Effects of cold exposure, exogenous melatonin and short-day treatment on the weight-regulation and body temperature of the Siberian hamster (Phodopus sungorus).cited 18× |
| endogenous melatonin | Decreases - were lower | plasma leptin concentrations | Animal | Siberian hamster | Not specified | Effects of cold exposure, exogenous melatonin and short-day treatment on the weight-regulation and body temperature of the Siberian hamster (Phodopus sungorus).cited 18× |
| 6 mg melatonin daily | Decreases - significant improvement | leptin serum levels | Human | participants with NAFLD | 6 mg daily, 1 hour before bedtime. | The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial.cited 29× |
| concurrent supplementation of melatonin | Decreases - prevents the effects of | leptin | Animal | these rats | Not specified | Could leptin be responsible for the reproductive dysfunction in obese men?cited 14× |