9
2
↑9
↓2
—0
Evidence suggests Melatonin mayincreaseImmune system.
23 studies (11 claims)
Moderate consensus
Typical effective dose 60 (40–80) mgacross 2 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin | Increases - boost the immune system | immune system | Human | healthy persons and obese and diabetic patients | Not specified | Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19.cited 52× |
| melatonin | Increases - has immunomodulatory action | immune system | Human | — | Not specified | Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19.cited 52× |
| Melatonin | No effect - modulation of immunity | immune system | HumanAnimal | — | — | Photoimmunomodulation and melatonin. |
| Melatonin | Increases - emerging as one of the most effective immunostimulatory compound | immune system | HumanAnimal | rodents | — | Photoimmunomodulation and melatonin. |
| Changes in level of melatonin | No effect - may lead to alterations (stimulatory/inhibitory) | immune system | HumanAnimal | — | — | Photoimmunomodulation and melatonin. |
| Melatonin | No effect - modulates | immune system | Human | — | Not specified | Bioactive Peptides in Dairy Milk: Highlighting the Role of Melatonin.cited 1× |
| melatonin | Increases - antioxidant and immunoenhancing actions | immune system | Human | — | Not specified | Oxidative stress and immunosenescence: therapeutic effects of melatonin.cited 65× |
| melatonin | Decreases - protective role against glucocorticoid-induced apoptosis | immune system | Human | — | — | Potential Mechanisms by which Glucocorticoids Induce Breast Carcinogenesis through Nrf2 Inhibition.cited 12× |
| melatonin | Increases - positively impact | immune system | Human | — | 20 mg (4 tablets of 5 mg) taken at 10 pm daily. | Adjuvant melatonin for uveal melanoma (AMUM): protocol for a randomized open-label phase III study.cited 2× |
| melatonin | No effect - may also act indirectly on | immune system | Human | — | Not specified | Melatonin in food allergy: Mechanism and potential therapy.cited 7× |
| melatonin | No effect - imparts a role in the modulation of | immune system | Human | — | Not specified | Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management.cited 15× |
| melatonin | Increases - may indirectly benefit | immune system | Human | patients with cancer | Not specified | Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review).cited 5× |
| melatonin | No effect - modulate | immune system | Human | — | 50-100 mg/day (proposed for future clinical trials). | Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies.cited 68× |
| melatonin | No effect - potently regulates | immune system | Human | — | Not specified | Melatonin and Multiple Sclerosis: From Plausible Neuropharmacological Mechanisms of Action to Experimental and Clinical Evidence.cited 15× |
| melatonin | Increases - enhance | immune system functions | Human | in vitro and in vivo models | — | The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature.cited 14× |
| melatonin | No effect - involved in immune regulation | maternal immune system | Animal | ovine thymus, lymph node, spleen and liver during early pregnancy | — | Expression of melatonin receptors and CD4 in the ovine thymus, lymph node, spleen and liver during early pregnancy. |
| Melatonin | No effect - modulates | the immune system | Human | — | — | Autoimmune hepatitis in association with ramelteon. |
| melatonin | No effect - to act directly upon | the immune system | Human | — | 670 nm, 4J/cm² | Melatonin as a principal component of red light therapy.cited 14× |
| melatonin | No effect - modulation of | various immune system cells and cytokines | Human | — | Not specified | Melatonin is a potential inhibitor of ovarian cancer: molecular aspects.cited 26× |