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Evidence suggests Melatonin mayincreaseGlutathione.
30 studies (39 claims)
Strong consensus
Typical effective dose 10 (10–17.5) mgacross 6 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin administration | Increases - caused a significant increase | glutathione (GSH) levels | Human | patients with diabetic nephropathy (DN) | 10 mg/d | Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy.cited 17× |
| melatonin administration | Increases - resulted in significant increases | plasma glutathione (GSH) | Human | diabetic patients with CHD | 10 mg melatonin (2 capsules of 5 mg each) once daily. | Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial.cited 94× |
| docosahexenoic acid (DHA)-phospholipids, melatonin and tryptophan supplemented diet | Increases - a significant increase was observed | ratio between reduced and oxidized glutathione | Human | elderly subjects suffering from mild cognitive impairment (MCI) | Not specified | Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment.cited 20× |
| Melatonin | Increases - stimulates | activities of the enzymes involved in the glutathione cycling and production | Human | — | Not specified | Update on the use of melatonin in pediatrics.cited 62× |
| Melatonin | Increases - restores | glutathione homeostasis | Human | — | Not specified | Update on the use of melatonin in pediatrics.cited 62× |
| melatonin | Increases - stimulating the synthesis of | antioxidant enzymes including superoxide dismutase, glutathione peroxidase, and glutathione reductase | Molecular | — | 50-100 mg/day (suggested for clinical trials) | Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.cited 215× |
| melatonin | Increases - augmenting | glutathione levels | Molecular | — | 50-100 mg/day (suggested for clinical trials) | Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.cited 215× |
| Melatonin | Increases - increased | expression levels and activities of superoxide dismutase 1 (SOD1) and glutathione peroxidase 4 (GPX4) | Animal | bovine intramuscular preadipocytes (BIPs) | — | Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes. |
| melatonin | Increases - may increase the expression of enzymes to synthesize the intracellular antioxidant, glutathione | expression of enzymes to synthesize the intracellular antioxidant, glutathione | Human | — | Not specified | "LONG COVID"-A hypothesis for understanding the biological basis and pharmacological treatment strategy.cited 77× |
| melatonin (MEL) | No effect - abrogated | glutathione decrease provoked by HMG | AnimalMolecular | in vitro models | — | 3-Hydroxy-3-methylglutaric and 3-methylglutaric acids impair redox status and energy production and transfer in rat heart: relevance for the pathophysiology of cardiac dysfunction in 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency. |
| melatonin (MEL) | No effect - abrogated | glutathione decrease provoked by MGA | AnimalMolecular | in vitro models | — | 3-Hydroxy-3-methylglutaric and 3-methylglutaric acids impair redox status and energy production and transfer in rat heart: relevance for the pathophysiology of cardiac dysfunction in 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency. |
| melatonin | Increases - markedly increased the expression | glutathione peroxidase (GPx) | HumanAnimal | rats | 6 mg/d orally in humans. | The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial.cited 77× |
| melatonin | Increases - upregulates activities of | superoxide dismutase 2 and glutathione peroxidase | HumanMolecular | — | Not specified | Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment.cited 13× |
| melatonin (MEL) and/or L-carnitine (L-CAR) | Increases - increased | glutathione (GSH) level | AnimalMolecular | isolated rat hepatocytes | — | Protective effects of melatonin and L-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes. |
| add-on melatonin with valproate | No effect - no significant difference between the groups | serum glutathione reductase | Human | adults with generalized epilepsy with generalized onset motor seizure | 3 mg/day melatonin (add-on to valproate 20 mg/kg in two divided doses). | Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial.cited 13× |
| add-on melatonin | Increases - increased significantly | serum glutathione reductase | Human | adults with generalized epilepsy with generalized onset motor seizure | 3 mg/day melatonin (add-on to valproate 20 mg/kg in two divided doses). | Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial.cited 13× |
| melatonin treatment (HFD-Mi + M) | Increases - enhancing | antioxidant enzyme glutathione peroxidase activity | Animal | — | Not specified | Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics. |
| melatonin treatment | Increases - caused increased expression levels | Cu/Zn-superoxide dismutase (SOD1) and glutathione reductase (GR) | Molecular | primary cultured normal and GCD2 corneal fibroblasts | — | Melatonin protects against oxidative stress in granular corneal dystrophy type 2 corneal fibroblasts by mechanisms that involve membrane melatonin receptors. |
| melatonin treatment | Increases - higher contents | glutathione (GSH) | Molecular | banana fruit | 500 μmol L-1 melatonin. | Comparative transcriptomic analysis reveals the reactive oxygen species metabolism involving in melatonin-alleviated chilling injury in postharvest banana fruit. |
| Melatonin (Mel) treatment | Increases - increased secretion | glutathione peroxidase 5 (GPX5) and prostaglandin D2 synthase (PTGDS) | Molecular | epididymal caput epithelial cells of Bactrian camels | — | Melatonin modulated GPX5 and PTGDS expression in Bactrian camel epididymis mainly via receptor MT1†. |
| melatonin supplementation | Increases - significantly increased | glutathione levels | Animal | porcine embryos | — | Melatonin reduces two-cell block via nonreceptor pathway in mice. |
| melatonin supplementation (20 mg/d) | Increases - higher | glutathione peroxidase (GPx) activity | Human | melatonin-treated group (MG) | — | Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes.cited 31× |
| melatonin supplementation | Increases - found a significant increase | levels of glutathione (GSH) | Human | patients with diabetes | Not specified in the abstract. | Effects of melatonin supplementation on markers of inflammation and oxidative stress in patients with diabetes: A systematic review and meta-analysis of randomized controlled trials.cited 11× |
| melatonin supplementation | Increases - significant elevation | total glutathione (GSH) levels | Human | patients with PD | 10 mg melatonin (two 5 mg capsules) once daily before bedtime. | Melatonin supplementation and the effects on clinical and metabolic status in Parkinson's disease: A randomized, double-blind, placebo-controlled trial.cited 53× |
| melatonin therapy | Increases - significantly improved | glutathione | Animal | male rodents | Not specified | Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies.cited 8× |
| melatonin therapy | Increases - significantly improved | glutathione peroxidase | Animal | male rodents | Not specified | Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies.cited 8× |
| melatonin therapy | Increases - were higher | testicular tissue glutathione peroxidase levels | Animal | rodents | — | Protective effects of melatonin against physical injuries to testicular tissue: A systematic review and meta-analysis of animal models.cited 14× |
| 50 μM melatonin | Increases - maintained higher levels of | contents of glutathione (GSH) | Human | loquat fruit | 50 μM melatonin. | Melatonin Treatment Alleviates Chilling Injury of Loquat Fruit via Modulating ROS Metabolism.cited 2× |