38
10
13
↑38
↓10
—13
Evidence suggests Melatonin mayincreaseGene expression.
30 studies (61 claims)
Moderate consensus
Typical effective dose 7.5 (5–10) mgacross 4 dosed studies
Study Claims
| Intervention | Direction | Endpoint | Type | Population | Dosage | Title |
|---|---|---|---|---|---|---|
| melatonin administration | Increases - could upregulate | gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) | Human | patients with diabetic nephropathy (DN) | 10 mg/d | Metabolic and Anti-inflammatory Response to Melatonin Administration in Patients with Diabetic Nephropathy.cited 17× |
| melatonin | Increases - underlie the oncostatic effects | alterations in gene expression following activation of various transcription factors | Human | — | Not specified | Mechanisms Underlying Tumor Suppressive Properties of Melatonin.cited 47× |
| melatonin | No effect - has been found to affect | clock gene expression in joints | Human | RA | Not specified | Reconsidering the Role of Melatonin in Rheumatoid Arthritis.cited 30× |
| melatonin | Increases - has a remarkable impact on epigenetic modulation of gene expression | epigenetic modulation of gene expression | Human | — | — | Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin. |
| melatonin | Increases - has a remarkable impact on epigenetic modulation of gene expression | epigenetic modulation of gene expression | Human | — | — | Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin. |
| Melatonin | Decreases - may reduce | Erk5 gene expression | AnimalMolecular | RAW 264.7 macrophages | — | Melatonin enhances the ability of M2 macrophages to secrete IL10 by inhibiting Erk5 signaling pathway. |
| melatonin | Increases - found eight upregulated genes and 16 downregulated genes that were appositively correlated with | gene expression | HumanAnimal | human breast cancer | Not specified | A meta-analysis of microRNA networks regulated by melatonin in cancer: Portrait of potential candidates for breast cancer treatment.cited 36× |
| melatonin | Decreases - prevents changes in gene expression | gene expression | Human | — | Not specified | Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis.cited 8× |
| melatonin (5 and 10 mg/kg, ip) | Increases - restored | gene expression levels of doublecortin, ki67, adamts20, and adam11 | Animal | stroke mice | — | Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice. |
| melatonin | Decreases - significantly inhibited | gene expression of aggrecan | Animal | rat VBGP chondrocytes | — | Effect of melatonin on the proliferation and differentiation of chondrocytes from rat vertebral body growth plate in vitro. |
| melatonin | Decreases - significantly inhibited | gene expression of collagen type II | Animal | rat VBGP chondrocytes | — | Effect of melatonin on the proliferation and differentiation of chondrocytes from rat vertebral body growth plate in vitro. |
| melatonin | Decreases - downregulated | gene expression of Bax | Animal | aged Wistar rats | — | Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats. |
| melatonin | Increases - upregulated | gene expression of Bcl-2 | Animal | aged Wistar rats | — | Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats. |
| melatonin | Decreases - downregulated | gene expression of Caspase-3 | Animal | aged Wistar rats | — | Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats. |
| melatonin | Increases - upregulated | gene expression of FOXO1 | Animal | aged Wistar rats | — | Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats. |
| melatonin | Increases - upregulated | gene expression of SIRT3 | Animal | aged Wistar rats | — | Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats. |
| melatonin | Increases - activating | gene expression of insulin-like growth factor-1 | Human | — | Not specified | The effects of melatonin on neurohormonal regulation in cardiac cachexia: A mechanistic review.cited 6× |
| melatonin | Decreases - inhibit | inflammatory gene expression and cytokine release, oxidative and nitrosative stress, mitochondrial dysfunction, neurotrophin dysregulation and apoptotic signalling | Human | — | Not specified | Putative neuroprotective pharmacotherapies to target the staged progression of mental illness.cited 28× |
| melatonin | Increases - significantly upregulated | melatonin receptor subtype melatonin receptor 1a (MT1) gene expression | AnimalMolecular | bovine mammary epithelial cells (BMECs) | — | Melatonin suppresses milk fat synthesis by inhibiting the mTOR signaling pathway via the MT1 receptor in bovine mammary epithelial cells. |
| melatonin | Increases - increased | morning clock gene expression | Human | breast cancer patients | 5 mg at bedtime | The effect of melatonin on sleep and quality of life in patients with advanced breast cancer.cited 74× |
| melatonin | No effect - modulates | oocyte-specific gene expression patterns | HumanAnimalMolecular | mammalian species | 10^-9 M melatonin for bovine oocytes (human dosage not specified). | Novel classifier orthologs of bovine and human oocytes matured in different melatonin environments.cited 4× |
| melatonin | Increases - induced | SIRT1 gene expression | HumanMolecular | cultured human granulosa-lutein (hGL) cells | Not specified | Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress.cited 15× |
| melatonin | Increases - induced | SIRT6 gene expression | HumanMolecular | cultured human granulosa-lutein (hGL) cells | Not specified | Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress.cited 15× |
| melatonin | Increases - induced | SIRT7 gene expression | HumanMolecular | cultured human granulosa-lutein (hGL) cells | Not specified | Celastrol and Melatonin Modify SIRT1, SIRT6 and SIRT7 Gene Expression and Improve the Response of Human Granulosa-Lutein Cells to Oxidative Stress.cited 15× |
| melatonin | Increases - influences | transcription factors which control neuronal and glial gene expression | Human | — | Not specified | Melatonin and Melatonergic Influence on Neuronal Transcription Factors: Implications for the Development of Novel Therapies for Neurodegenerative Disorders.cited 10× |
| melatonin-coated lactoferrin-chitosan nanoparticles (ETP-CS-LF-MLT-NPs) | Decreases - notable downregulation | BCL2 gene expression | HumanAnimalMolecular | HCT116 cells | Not specified in the abstract. | Fabrication of lactoferrin-chitosan-etoposide nanoparticles with melatonin via carbodiimide coupling: In-vitro & in-vivo evaluation for colon cancer.cited 2× |
| melatonin (MT) treatment | Increases - significantly upregulated | VvANR gene expression levels | Animal | postharvest mature grape | Not specified | Exogenous melatonin and salicylic acid enhance postharvest quality and boost antioxidant capacity in Vitis vinifera cv. 'Cuibao seedless' grape berries. |
| melatonin (MT) treatment | Increases - significantly upregulated | VvCHI gene expression levels | Animal | postharvest mature grape | Not specified | Exogenous melatonin and salicylic acid enhance postharvest quality and boost antioxidant capacity in Vitis vinifera cv. 'Cuibao seedless' grape berries. |
| melatonin (MT) treatment | Increases - significantly upregulated | VvF3H2 gene expression levels | Animal | postharvest mature grape | Not specified | Exogenous melatonin and salicylic acid enhance postharvest quality and boost antioxidant capacity in Vitis vinifera cv. 'Cuibao seedless' grape berries. |
| melatonin (MT) treatment | Increases - significantly upregulated | VvPAL gene expression levels | Animal | postharvest mature grape | Not specified | Exogenous melatonin and salicylic acid enhance postharvest quality and boost antioxidant capacity in Vitis vinifera cv. 'Cuibao seedless' grape berries. |
| melatonin supplementation | Increases - upregulated | gene expression of low-density lipoprotein receptor (LDLR) | Human | women with polycystic ovary syndrome (PCOS) | 10 mg melatonin (two 5 mg capsules) once daily before bedtime. | Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.cited 58× |
| melatonin supplementation | Increases - upregulated | gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) | Human | women with polycystic ovary syndrome (PCOS) | 10 mg melatonin (two 5 mg capsules) once daily before bedtime. | Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial.cited 58× |
| melatonin supplementation | Decreases - positive effects | reducing endocannabinoid levels, the expression of the ghrelin hormone gene, the level of ghrelin, and the cannabinoid receptor type 1 gene expression | Human | animal studies | 5 mg/day melatonin. | The effect of melatonin supplementation on the plasma levels of 2-arachidonoylglycerol, ghrelin and hedonic eating intensity in overweight/obese females: A study protocol for a pilot randomized controlled trial. |
| melatonin receptors (MT1 and MT2) | Increases - highest expression | gene expression | Human | adult male European bisons | — | New insight on the role of melatonin receptors in reproductive processes of seasonal breeders on the example of mature male European bison (Bison bonasus, Linnaeus 1758). |
| chronic melatonin treatment | Increases - reversed | downregulation of CREB and BDNF gene expression levels | Animal | BALB/c mice | — | The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice. |